Association of different patterns of expression of beta-catenin and cyclin D1 with pathogenesis of breast carcinoma

Varma, Kachnar; Chauhan, Aprajita; Bhargava, M; Misra, Vatsala; Srivastava, Sapan

doi:10.4103/ijpm.ijpm_419_19

Cited by 11 publications

(10 citation statements)

References 17 publications

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“…(2) membranous: circumferential membrane staining present in the tumor cells; grade 1: loss of membranous staining; grade 2: cytoplasmic expression with or without loss of membranous staining [37,38].…”

Section: Evaluation Of the Immunohistochemical Labelingmentioning

confidence: 99%

Impact of Epithelial–Mesenchymal Transition on the Immune Landscape in Breast Cancer

Khadri

Issac

Gaboury

2021

Cancers

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The impact of epithelial–mesenchymal transition (EMT) signature on the immune infiltrate present in the breast cancer tumor microenvironment (TME) is still poorly understood. Since there is mounting interest in the use of immunotherapy for the treatment of subsets of breast cancer patients, it is of major importance to understand the fundamental tumor characteristics which dictate the inter-tumor heterogeneity in immune landscapes. We aimed to assess the impact of EMT-related markers on the nature and magnitude of the inflammatory infiltrate present in breast cancer TME and their association with the clinicopathological parameters. Tissue microarrays were constructed from 144 formalin-fixed paraffin-embedded invasive breast cancer tumor samples. The protein expression patterns of Snail, Twist, ZEB1, N-cadherin, Vimentin, GRHL2, E-cadherin, and EpCAM were examined by immunohistochemistry (IHC). The inflammatory infiltrate in the TME was assessed semi-quantitatively on hematoxylin and eosin (H&E)-stained whole sections and was characterized using IHC. The inflammatory infiltrate was more intense in poorly differentiated carcinomas and triple-negative carcinomas in which the expression of E-cadherin and GRHL2 was reduced, while EpCAM was overexpressed. Most EMT-related markers correlated with plasma cell infiltration of the TME. Taken together, our findings reveal that the EMT signature might impact the immune response in the TME.

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Section: Evaluation Of the Immunohistochemical Labelingmentioning

confidence: 99%

Impact of Epithelial–Mesenchymal Transition on the Immune Landscape in Breast Cancer

Khadri

Issac

Gaboury

2021

Cancers

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“…Some studies have suggested the role of β-catenin as a proto-oncogene, which causes many cancers, such as colon cancer (Varma et al, 2020).…”

Section: Determination Of β-Catenin Expression In Breast Cancer and Its Relationship With Clinicopathologic Parametersmentioning

confidence: 99%

“…In addition to the above, identifying novel biomarkers involved in tumor invasion and metastasis can help determine the tumor's prognosis and new targeted therapies (O'Shaughnessy, 2006;Staaf et al, 2010;Wang et al, 2015). Several signaling pathways, including Wnt, are involved in breast cancer (Khan et al, 2018;Varma et al, 2020). β-catenin is an oncogene (López-Knowles et al, 2010) and is an essential intermediate in the Wnt signaling pathway (Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Determination of β-catenin Expression in Breast Cancer and Its Relationship with Clinicopathologic Parameters

Sefidbakht

Saeedipour

Saffar

et al. 2021

Asian Pac J Cancer Prev

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Background: Abnormal activation of the β-catenin signaling pathway is involved in various malignancies, including breast carcinoma.Aberrant expression of β-catenin has been associated with more aggressive behaviors of breast cancer in some previous studies. . In the present study, we intend to evaluate the β-catenin expression in breast cancer specimens and study its relationship with clinicopathological parameters. Materials and method: In this crosssectional study,88 samples diagnosed as invasive ductal breast carcinoma from 2007 to 2017 were evaluated. The slides and paraffin blocks were retrieved from the archive of pathology department. Patients' clinical characteristics and other information were also extracted from medical documents. Sections from related paraffin blocks through the tissue microarray method were provided, and immunohistochemistry staining for β-catenin was done. Then different patterns of β-catenin expression and the relationship between different patterns and clinicopathological parameters were investigated. Results: Of the 88 breast cancer samples, 94% were female, and 6% were male. In 70% of the samples, normal membrane expression of β-catenin was observed. Whereas in 30% of them, aberrant expression of β-catenin was observed. A close significant relationship was observed between aberrant β-catenin expression and age over 50 years (p-value: 0.093) and negative HER2 (p-value: 0.07). Conclusion: In the present study, a correlation was observed between aberrant β-catenin expression and age over 50 years in patients and HER2 negativity, although this association was not statistically significant.

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“…[10][11][12][13] Although the relationships of these genes with other tumors have become increasingly clear with every research done, and although these genes have been known to offer a range of promotional or inhibitive effects on different tumors, relevant information on breast cancer has not been sufficiently investigated, while their correlations with the patients' clinical characteristics are also yet to be clarified. [14][15][16][17] In light of this background, this study collected specimens from patients during clinical practices to test the levels of expression of these genes and analyze how the changes in their expression levels would correlate with the patients' age, sex, tumor size, lymphatic metastasis, TNM staging, etc., providing some theoretical grounds for a deeper understanding into the pathogenesis of and development of cure for breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances

et al. 2021

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As the leading malignancy among women, breast cancer is a serious threat to the life and health of women. In this context, it is of particular importance that a proper therapeutic target be identified for breast cancer treatment. We collected the pathological tissues of 80 patients, with the view to discovering appropriate molecular targets for the treatment of breast cancer, this paper analyzes the expressions of ZNF436, β-catenin, EGFR and CMTM5 in breast cancer tissues, as well as their correlations with breast cancer in combination with the clinicopathologic characteristics of studied patients. Immunohistochemistry (IHC) was utilized to detect the expression levels of ZNF436, β-catenin, EGFR and CMTM5 in cancerous and paracancerous tissues of breast cancer patients. The expression levels of ZNF436, β-Catenin and EGFR in breast cancer tissues were significantly greater than those in paracancerous tissues in this study (p<0.05), while CMTM5 was highly expressed in paracancerous tissues (p<0.05). Additionally, the correlation of the expressions of such indicators with the staging, differentiation and lymphatic metastasis of breast cancer, were also found to be statistically significant at the level p<0.05. The different expression levels of ZNF436, β-catenin, EGFR and CMTM5 in breast cancer and paracancerous tissues open up the possibility of utilizing them as molecular markers for breast cancer. These findings provide a theoretical basis for targeted molecular therapies for breast cancer, and hence carry a significant practical significance.

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Association of different patterns of expression of beta-catenin and cyclin D1 with pathogenesis of breast carcinoma

Cited by 11 publications

References 17 publications

Impact of Epithelial–Mesenchymal Transition on the Immune Landscape in Breast Cancer

Impact of Epithelial–Mesenchymal Transition on the Immune Landscape in Breast Cancer

Determination of β-catenin Expression in Breast Cancer and Its Relationship with Clinicopathologic Parameters

Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances

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