Association of different lipid measures with incident bone fractures: Tehran lipid and glucose study

Tohidi, Maryam; Barzegar, Niloofar; Hasheminia, Mitra; Azizi, Fereidoun; Hadaegh, Farzad

doi:10.1080/00325481.2022.2050980

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…12 Many studies reported that the association of lipids and incident bone fractures may be nonlinear, while few studies discussed the relationship between lipids and the outcomes of hip fractures. 13 Lipids play significant roles in bone metabolism, immune responses, oxidative stress, and regulation of inflammation, and all these physiological and pathological processes have been proven to relate to the prognosis of hip fractures. [14][15][16] Therefore, we hypothesize that lipids may be implicated in the prognosis of elderly patients with hip fractures through the mechanisms described above.…”

Section: Introductionmentioning

confidence: 99%

The Paradoxical Association of Lipids with Survival and Walking Ability of Hip Fractures in Geriatric Patients After Surgery: A 1-Year Follow-Up Study

Zhao,

Fan,

Wang

et al. 2023

IJGM

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Background:We aimed to explore the association between lipids and the survival and walking ability of hip fractures in geriatric patients after surgery. Methods: Restricted cubic spline (RCS) was established to explore the nonlinear relationship between lipids and 1-year mortality of hip fractures, and the cut-off points were also determined by RCS. Then, the patients were divided into three groups: low, middle, and high levels of LDL-c. Then, the survival and walking ability of patients from different groups were compared, and the Cox regression and Logistics regression were used to identify the relationships between lipids and the survival and walking ability of hip fractures. Results:The patients with middle levels of LDL-c had a significantly high survival probability than those with low or high levels of LDL-c (p < 0.001). The patients with low levels of LDL-c and with high levels of LDL-c may have a poor prognosis compared with patients with middle levels of LDL-c in 6-month mortality, 6-month free walking ability, 1-year mortality, and 1-year free walking ability (All p < 0.05). Conclusion:Low and high levels of LDL-c may both relate to the poor survival and walking ability of hip fractures.

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Section: Introductionmentioning

confidence: 99%

The Paradoxical Association of Lipids with Survival and Walking Ability of Hip Fractures in Geriatric Patients After Surgery: A 1-Year Follow-Up Study

Zhao,

Fan,

Wang

et al. 2023

IJGM

View full text Add to dashboard Cite

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The interplay between circulating high-density lipoprotein, age and fracture risk: a new cohort study and systematic meta-analysis

Kunutsor¹,

Laukkanen²

2023

GeroScience

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Previous findings on the association between high-density lipoprotein cholesterol (HDL-C) and fracture have yielded inconsistent results and it is unclear if the association varies with age and sex. We sought to evaluate the prospective association between HDL-C levels and fracture risk and assess if the association is modified by age and sex. Circulating HDL-C levels were measured at baseline in a population-based sample of 2,448 men aged 42–61 years. Cox regression was used to estimate hazard ratios (HRs) and 95% CIs. Incident fractures (n = 134) occurred during a median follow-up of 25.7 years. In analysis adjusted for several risk factors, the HR (95% CI) for fractures was 1.00 (0.85–1.20) per 1 standard deviation (SD) increase in HDL-C levels. Comparing the extreme tertiles of HDL-C levels, the corresponding adjusted HR (95% CI) was 0.94 (0.62–1.45). In a meta-analysis of eight cohort studies (including the current study) comprising 74,378 participants and 4,621 fracture cases, the fully-adjusted risk estimate (95% CI) for fracture was 1.03 (0.96–1.10) per 1SD increase in HDL-C levels and 1.05 (0.92–1.20) comparing extreme tertiles of HDL-C. The pooled risk estimate (95% CIs) for fracture per 1SD increase were 1.09 (1.01–1.17) and 0.98 (0.93–1.04) for age groups ≥ 60 and < 60 years, respectively, and the corresponding risks comparing the extreme tertiles of HDL-C levels were 1.21 (1.09–1.33) and 0.95 (0.85–1.07) (p-value for interaction < 0.05). Age may modify the association between HDL-C levels and fracture risk – an increased fracture risk associated with increased HDL-C levels is only evident in older age (≥ 60 years).

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Association of different lipid measures with incident bone fractures: Tehran lipid and glucose study

Cited by 2 publications

References 36 publications

The Paradoxical Association of Lipids with Survival and Walking Ability of Hip Fractures in Geriatric Patients After Surgery: A 1-Year Follow-Up Study

The Paradoxical Association of Lipids with Survival and Walking Ability of Hip Fractures in Geriatric Patients After Surgery: A 1-Year Follow-Up Study

The interplay between circulating high-density lipoprotein, age and fracture risk: a new cohort study and systematic meta-analysis

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