Association of Dietary Vitamin D Intake, Serum 25(OH)D3, 25(OH)D2 with Cognitive Performance in the Elderly

Wang, RuTong; Wang, Weijing; Hu, Ping; Zhang, Ronghui; Dong, Xiaofeng; Zhang, Dongfeng

doi:10.3390/nu13093089

Cited by 27 publications

(23 citation statements)

References 39 publications

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“…Second, urinary 3-PBA has an estimated half-life of only 6-24 h [17][18][19][20], and thus may not be able to capture cumulative pyrethroid exposure in the human body. Third, we adjusted clinical factors such as BMI, hypertension, and diabetes, as potential confounders, as previous studies suggested [26,27]. However, we cannot rule out a possibility that those clinical factors may be potential causal intermediaries rather than confounding factors since they are the risk factor for cognitive impairment in older adults.…”

Section: Discussionmentioning

confidence: 99%

“…Third, general health behaviors including physical activity and smoking pack-year were additionally considered. Last, physical status including body mass index (BMI) and presence of hypertension and diabetes were additionally considered as confounding variables [26,27]. Further, urinary creatinine concentration was considered as a potential confounder [28].…”

Section: Covariatesmentioning

confidence: 99%

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Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002

Kim

Hong

Choi

2021

IJERPH

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Pyrethroid compounds are widely used in household insecticides and agricultural pesticides. Recent studies, however, report that pyrethroid exposures affect neurobehavioral function in animals and may be associated with adverse neurocognitive development in children. This study aimed to examine the association between pyrethroid exposure and cognitive dysfunction in older adults using a well-defined general population. We analyzed data from 336 individuals, aged 60–84 years, who participated in the National Health and Nutrition Examination Survey 2001–2002. We used urinary 3-phenoxybenzoic acid (3-PBA) concentration as a biomarker of pyrethroid exposures and assessed cognitive function with the digit–symbol coding test. The geometric means (±geometric standard errors) of creatinine-uncorrected and corrected urinary 3-PBA were 0.30 (±0.87) μg/L and 0.36 (±0.89) μg/g. After adjusting for sociodemographic factors, higher 3-PBA concentrations (> vs. ≤0.30 μg/g creatinine (median)) were associated with lower scores of cognitive function (−3.83 95% confidence interval: −7.11, −0.54). Significance was persistent after additionally adjusting for physical activity and smoking pack-year (−3.76 95% CI: −7.16, −0.36) and further adjusting for BMI and presence of hypertension and diabetes (−3.82 95% CI: −6.92, −0.71). Our findings suggest that pyrethroid exposure is associated with cognitive dysfunction in older adults.

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Section: Discussionmentioning

confidence: 99%

Section: Covariatesmentioning

confidence: 99%

Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002

Kim

Hong

Choi

2021

IJERPH

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“…According to the method used in the published literature ( 3 , 5 , 7 , 22 , 27 ), we further classified the scores according to three age stages. In each test, participants with scores below the minimum quartile for each age group were defined as having low poor cognitive performance.…”

Section: Methodsmentioning

confidence: 99%

“…Cognitive function is associated with a variety of factors ( 1 , 2 ). Many previous studies have discussed the association between nutritional factors and cognition, such as vitamin D ( 3 , 4 ), zinc, copper, selenium ( 5 ), creatine ( 6 ), ω-3, and ω-6 fatty acids ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Association of Dietary Vitamin K Intake With Cognition in the Elderly

et al. 2022

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Several previous studies discussed the association between vitamin K (VK) status and cognition. But the association between dietary VK consumption and cognitive performance in the elderly was not well understood. Therefore, we investigated the correlation between dietary VK intake and the cognition of the elderly. Our research used the data of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014. The dietary intake of VK was assessed by two 24-h dietary recalls. The cognitive function was measured in the survey of NHANES, including the Consortium to Establish a Registry for Alzheimer’s disease Word Learning subtest (CERAD W-L), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). Logistic regression and restricted cubic spline models were applied to assess the relationship between dietary VK intake and cognition. Compared with the lowest dietary VK intake group, the multivariate-adjusted odds ratio (OR) [95% confidence interval (95% CI)] of low CERAD W-L score for the highest intake group was 0.39 (0.26–0.60), the multivariate-adjusted OR (95% CI) of low AFT score was 0.59 (0.38–0.92), and the multivariate-adjusted OR (95% CI) of low DSST score was 0.44 (0.29–0.65), respectively. There was an L-shaped dose–response relationship between dietary VK intake and low CERAD W-L score. There was a linear dose–response relationship between dietary VK intake and low AFT score, and there was also a linear dose–response relationship for the low DSST score. In addition, we also found a negative association between VK from vegetables and the risk of low CERAD W-L scores. Dietary VK intake and VK intake from vegetables were inversely related to the risk of low cognitive performance of the elderly.

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“…As there is no recommended standard for cognitive impairment by CERAD-WL, CERAD-DR, AFT and DSST, the lowest quartile of these four scores was used as the cut-off points, which were adjusted according to age (Table 1) (27). Participants with scores lower than or equal to the cut-off points were defined as cognitive impairment.…”

Section: Cognitive Function Assessmentmentioning

confidence: 99%

Hypertension, dietary fiber intake, and cognitive function in older adults [from the National Health and Nutrition Examination Survey Data (2011–2014)]

Zhang

Tian

et al. 2022

Front. Nutr.

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BackgroundDietary fiber was associated with hypertension (HYP) and cognitive function, but it was unknown whether the effect of HYP on cognitive function in older adults was modified by dietary fiber intake.MethodsWe recruited 2,478 participants from the 2011–2012 and 2013–2014 National Health and Nutrition Examination Survey (NHANES), with cognitive performance measured by Registry for Alzheimer's disease (CERAD), the Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). Multivariate General linear model was used to estimate the interaction between dietary fiber intake and HYP status in association with low cognitive performance.ResultsAmong 2,478 participants, 36% was Controlled HYP, 25% was Low uncontrolled HYP, 11% was High uncontrolled HYP, and 86% was low dietary fiber intake. The association between HYP status and DSST impairment differed by dietary fiber intake for those with high uncontrolled HYP compared to those without HYP. Among participants with low dietary fiber intake, those with uncontrolled HYP had higher risk of DSST impairment compared to those without HYP [HYP ≥ 90/140: OR (95% CI), 1.68 (1.15–2.45); HYP ≥ 100/160: OR (95%CI), 2.05 (1.29–3.23)]; however, there was no association between HYP status and DSST impairment among participants with high dietary fiber intake. Moreover, the interaction of HYP status and dietary fiber intake on DSST was close to statistical significance (P for interaction = 0.057).ConclusionsUncontrolled HYP was associated with poorer cognitive performance in older adults with low, but not high dietary fiber intake. Sufficient dietary fiber intake might be as a new nutrition strategy for the prevention of cognitive impairment in older adults with uncontrolled HYP.

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Association of Dietary Vitamin D Intake, Serum 25(OH)D3, 25(OH)D2 with Cognitive Performance in the Elderly

Cited by 27 publications

References 39 publications

Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002

Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001–2002

Association of Dietary Vitamin K Intake With Cognition in the Elderly

Hypertension, dietary fiber intake, and cognitive function in older adults [from the National Health and Nutrition Examination Survey Data (2011–2014)]

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