2007
DOI: 10.1161/circulationaha.106.683755
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Association of Dietary Intake of Soy, Beans, and Isoflavones With Risk of Cerebral and Myocardial Infarctions in Japanese Populations

Abstract: MD; for the JPHC Study GroupBackground-Soy and isoflavones have been proposed to reduce the risk of cardiovascular risk factors, but their potential as preventatives for cardiovascular disease remains uncertain. We investigated the association of soy and isoflavone intake with risk of cerebral and myocardial infarctions (CI and MI). Methods and Results-To examine the association of soy and isoflavone intake with the risk of CI and MI, we studied 40 462 Japanese (40 to 59 years old, without cardiovascular disea… Show more

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Cited by 249 publications
(235 citation statements)
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“…One possible explanation for the lack of significant results in meta-analyses of studies conducted in Mediterranean countries could be the impact on cardiovascular health of all components of the diet typically consumed in these countries, or at least those included in the individual analyses. (17) Bernstein et al (2010) (23) , F Buckland et al (2009) (20) , M Kelemen et al (2005) (18) , F Kokubo et al (2007) (19) , M Buckland et al (2009) (20) , F Kokubo et al (2007) (19) , F Martinez-Gonzalez et al (2011) (24) Nagura et al (2009) (22) Dilis et al (2012) (25) , F Dilis et al (2012) (25) , M Haring et al (2014) (23) Total ( (19) , M Mizrahi et al (2009) (21) Misirili et al (2012) (27) Haring et al (2015) (29) Total ( (24) Bazzano et al (2001) (17) Kokubo et al (2007) (19) , F Kokubo et al (2007) (19) , M Nouri et al (2016) (30) Nagura et al (2009) (22) Total ( The study-specific RR and 95 % CI are represented by the black square and horizontal line, respectively; the area of the black square is proportional ...…”
Section: Discussionmentioning
confidence: 99%
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“…One possible explanation for the lack of significant results in meta-analyses of studies conducted in Mediterranean countries could be the impact on cardiovascular health of all components of the diet typically consumed in these countries, or at least those included in the individual analyses. (17) Bernstein et al (2010) (23) , F Buckland et al (2009) (20) , M Kelemen et al (2005) (18) , F Kokubo et al (2007) (19) , M Buckland et al (2009) (20) , F Kokubo et al (2007) (19) , F Martinez-Gonzalez et al (2011) (24) Nagura et al (2009) (22) Dilis et al (2012) (25) , F Dilis et al (2012) (25) , M Haring et al (2014) (23) Total ( (19) , M Mizrahi et al (2009) (21) Misirili et al (2012) (27) Haring et al (2015) (29) Total ( (24) Bazzano et al (2001) (17) Kokubo et al (2007) (19) , F Kokubo et al (2007) (19) , M Nouri et al (2016) (30) Nagura et al (2009) (22) Total ( The study-specific RR and 95 % CI are represented by the black square and horizontal line, respectively; the area of the black square is proportional ...…”
Section: Discussionmentioning
confidence: 99%
“…Legume consumption and CHD risk The analysis relative to CHD risk related to consumption of legumes comprised twelve data sets derived from eight studies (17)(18)(19)(20)23,24,25,28) . Comparison of the highest v. the lowest legume consumption category showed a similar risk estimate to the previous analysis considering CVD as outcome (RR = 0·90; 95 % CI 0·84, 0·97; Fig.…”
Section: Legume Consumption and Cvd Risk 249mentioning
confidence: 99%
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