Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women

Tabung, Fred K.; Liu, Li; Wang, Weike; Fung, Teresa T.; Wu, Kana; Smith‐Warner, Stephanie A.; Cao, Yin; Hu, Frank B.; Ogino, Shuji; Fuchs, Charles S.; Giovannucci, Edward

doi:10.1001/jamaoncol.2017.4844

Cited by 146 publications

(104 citation statements)

References 38 publications

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“…For example, associations have been uncovered between CRC and moderate consumption of sugar-sweetened beverages,43 as well as high fructose corn syrup specifically in animal studies,44 both in the absence of obesity and metabolic syndrome. An inflammatory diet, characterised by high consumption of processed foods and high-glycaemic load carbohydrates, creates an environment conducive to colonic proliferation45 and appears to increase CRC risk 46. What remains uncertain is how these dietary elements might influence early-life gut health.…”

Section: Discussionmentioning

confidence: 99%

Global patterns and trends in colorectal cancer incidence in young adults

Siegel

Torre

Soerjomataram

et al. 2019

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ObjectiveEarly-onset colorectal cancer (CRC) is increasing in the USA despite rapid declines in older ages. Similar patterns are reported in Australia and Canada, but a comprehensive global analysis of contemporary data is lacking.DesignWe extracted long-term data from Cancer Incidence in Five Continents and supplemental sources to report on worldwide CRC incidence rates and trends by age (20–49 years and ≥50 years) through diagnosis year 2012 or beyond (Australia, Finland, New Zealand, Norway, Sweden, USA).ResultsDuring 2008–2012, age-standardised CRC incidence rates in adults <50 ranged from 3.5 per 100 000 (95% CI 3.2 to 3.9) in India (Chennai) to 12.9 (95% CI 12.6 to 13.3) in Korea. During the most recent decade of available data, incidence in adults <50 was stable in 14 of 36 countries; declined in Austria, Italy and Lithuania; and increased in 19 countries, nine of which had stable or declining trends in older adults (Australia, Canada, Denmark, Germany, New Zealand, Slovenia, Sweden, UK and USA). In Cyprus, Netherlands and Norway, inclines in incidence in young adults were twice as rapid as those in older adults (eg, Norway average annual per cent change (AAPC), 1.9 (95% CI 1.4 to 2.5) vs 0.5 (95% CI 0.3 to 0.7)). Among most high-income countries with long-term data, the uptick in early-onset disease began in the mid-1990s. The steepest increases in young adults were in Korea (AAPC, 4.2 (95% CI 3.4 to 5.0)) and New Zealand (AAPC, 4.0 (95% CI 2.1 to 6.0)).ConclusionCRC incidence increased exclusively in young adults in nine high-income countries spanning three continents, potentially signalling changes in early-life exposures that influence large bowel carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Global patterns and trends in colorectal cancer incidence in young adults

Siegel

Torre

Soerjomataram

et al. 2019

Gut

547

417

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“…The EDIP includes 18 components that partially overlap with the AIDI (nine anti‐inflammatory and nine pro‐inflammatory) and was identified with a step‐wise linear regression analysis based on hsCRP, TNFα receptor 2 and IL‐6 . In a US‐based population, a significant association between the pro‐inflammatory diet potential (measured using the EDIP) and risk of colorectal but not ovarian cancer has been observed. Our results are also in line with the findings of a meta‐analysis of dietary patterns and all‐cause and CVD mortality , where a ‘prudent’ dietary pattern (high consumption of fruits, vegetables, wholegrains and fish), which partially overlaps with the AIDI components, was associated with lower risks of all‐cause (26% reduction, 95% CI: 14–32%) and CVD (19% (95% CI: 13–25%) mortality.…”

Section: Discussionmentioning

confidence: 99%

Influence of anti‐inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies

et al. 2018

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“…Among at-risk individuals, erythrocyte membrane-bound omega-3 PUFA levels were inversely associated with anti-CCP/RF positivity [15]. Previous studies investigating EDIP found robust associations between EDIP scores and colorectal cancer risk but no association with ovarian cancer risk [16, 17]. Similar to previous studies investigating dietary/metabolic factors in RA, the inflammatory dietary pattern was important specifically in younger-onset seropositive RA, defined as ≤55 years [5, 6, 12].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women

et al. 2018

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Our objective was to investigate whether a dietary pattern derived using inflammatory biomarkers is associated with rheumatoid arthritis (RA) risk. We prospectively followed 79,988 women in the Nurses' Health Study (NHS, 1984-2014) and 93,572 women in the NHSII (1991-2013); incident RA was confirmed by medical records. Food frequency questionnaires (FFQ) were completed at baseline and approximately every 4 years. Inflammatory dietary pattern was assessed from FFQ data using the Empirical Dietary Inflammatory Pattern (EDIP), including 18 anti-/pro-inflammatory food/beverage groups weighted by correlations with plasma inflammatory biomarkers (interleukin-6, C-reactive protein, and tumor necrosis factor-α receptor 2). We investigated associations between EDIP and RA using Cox regression. We identified 1185 incident RA cases over 4,425,434 person-years. EDIP was not associated with overall RA risk (p trend = 0.21 across EDIP quartiles). Among women ≤ 55 years, increasing EDIP was associated with increased overall RA risk; HRs (95% CIs) across EDIP quartiles were 1.00 (reference), 1.14 (0.86-1.51), 1.35 (1.03-1.77), and 1.38 (1.05-1.83; p for trend = 0.01). Adjusting for BMI attenuated this association. Increasing EDIP was associated with increased seropositive RA risk among women ≤ 55 years (p for trend = 0.04). There was no association between EDIP and RA among women > 55 years (EDIP-age interaction, p = 0.03). An inflammatory dietary pattern was associated with increased seropositive RA risk with onset ≤ 55 years old, and this association may be partially mediated through BMI.

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Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women

Cited by 146 publications

References 38 publications

Global patterns and trends in colorectal cancer incidence in young adults

Global patterns and trends in colorectal cancer incidence in young adults

Influence of anti‐inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies

Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women

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