Association of Dietary and Serum Cholesterol with Active Pulmonary Tuberculosis: A Hospital Based Study

Prabakaran, J.; Efrem, Biniam; Araya, Matiwos; Mebrahtu, Mussie; Zeraburuk, Henok; Michael, Yemane; Semere, Adiam; Ghebreyesus, Awet

doi:10.20546/ijcmas.2017.612.467

Cited by 1 publication

(4 citation statements)

References 20 publications

(29 reference statements)

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“…The lipid profiles (CHO, TAG, and HDL) and immunohematological values failed to demonstrated significant association with sputum bacilli load in the present study. Unlike this study, studies done elsewhere, reported a negative correlation between serum lipid values and sputum bacilli load [ 32 , 34 , 70 ]. This negative correlation might be due to high oxidative stress and elevated cytokines [ 32 ].…”

Section: Discussioncontrasting

confidence: 84%

“…Unlike this study, studies done elsewhere, reported a negative correlation between serum lipid values and sputum bacilli load [ 32 , 34 , 70 ]. This negative correlation might be due to high oxidative stress and elevated cytokines [ 32 ].…”

Section: Discussioncontrasting

confidence: 84%

“…Higher serum CHO levels were associated with lower mortality and considered as a marker of lower levels of inflammation in TB patients and this condition was unaffected by BMI [ 64 ]. On the contrary, low serum CHO in PTB cases might be due to high oxidative stress and elevated cytokines [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hence we hypothesized that host serum lipid values would demonstrated correlation with forms of TB (PTB Vs TBLN), sputum bacilli load (low, medium and high) and Mtb time to culture positivity. Several lines of evidences showed apparent association between serum lipid value with TB [ 32 – 34 ], risk of TB [ 35 ], smear grading [ 32 , 34 ], disease severity and inflammation [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparative serum lipid and immunohematological values among adult pulmonary tuberculosis and tuberculosis lymphadenitis cases and their association with sputum bacilli load and time to culture positivity in Northwestern Ethiopia

Mekonnen¹,

Nibret²,

Munshea³

et al. 2023

Lipids Health Dis

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Background The serum lipid and immunohematological values of tuberculosis lymphadenitis (TBLN) patients is poorly documented relative to pulmonary tuberculosis (PTB) cases. Therefore, the aim of this study was to investigate the serum lipid and immunohematological values of patients with TBLN in comparison with PTB (PTB) patients. Methods An institution-based comparative cross-sectional study was conducted in Northwest Ethiopia from March to December 2021. The study participants were bacteriologically confirmed PTB (n = 82) and TBLN (n = 94) cases with no known comorbidity and whose ages was greater than 18 years and with no current pregnancy. Independent sample t-test, one-way ANOVA, box plot, and correlation matrix were used to analyze the data. Results The body mass index (BMI), CD4 + T cell count, and high-density lipoprotein-Cholesterol (HDL-C) values were significantly higher among TBLN cases compared with PTB cases. Additionally, the total white blood cell (WBC) count, hemoglobin (Hb), total Cholesterol (CHO) and creatinine (Cr) values were relatively higher among TBLN than PTB (P > 0.05). On the reverse, the platelet count and triacylglycerol (TAG) values were relatively higher among PTB than in TBLN cases. While the mean days of culture positivity were 11.6 days for TBLN, the mean days of culture positivity were 14.0 days for PTB. Anemia and serum lipid values showed no correlation with sputum bacilli load and time to culture positivity. Conclusion Tuberculous lymphadenitis patients were well-endowed with serum lipid, immunological and nutritional status compared with PTB cases. Hence, the high incidence rate of TBLN in Ethiopia could not be explained by low peripheral immunohematological values, malnutrition, Anemia, and dyslipidemia. Further study for identifying the predictors for TBLN in Ethiopia is highly desirable.

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Section: Discussioncontrasting

confidence: 84%