Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study

Arisawa, Kokichi; Katsuura‐Kamano, Sakurako; Uemura, Hirokazu; Tien, Nguyen Van; Hishida, Asahi; Tamura, Takashi; Kubo, Yoko; Tsukamoto, Mineko; Tanaka, Keitaro; Hara, Megumi; Takezaki, Toshiro; Nishimoto, Daisaku; Koyama, Teruhide; Ozaki, Etsuko; Suzuki, Sadao; Nishiyama, Takeshi; Kuriki, Kiyonori; Kadota, Aya; Takashima, Naoyuki; Ikezaki, Hiroaki; Murata, Masayuki; Oze, Isao; Matsuo, Keitaro; Mikami, Haruo; Nakamura, Yohko; Takeuchi, Kenji; Wakai, Kenji

doi:10.3390/nu12061605

Cited by 23 publications

(33 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were obtained by analyzing NEAP quartiles and MetS prevalence. These results are in agreement with previous reports indicating similar associations between PRAL as well as NEAP and the prevalence of MetS in Iranian patients with type 2 diabetes ( 40 ) and a cross-sectional Japanese study, in which higher NEAP values (PRAL was not calculated) were associated with an increased prevalence of MetS independently of sex, age, and BMI ( 17 ). Contradictory results were described by Jafari et al ( 41 ) who observed an association between MetS prevalence and NEAP but not PRAL in a cohort of Iranian men.…”

Section: Discussionsupporting

confidence: 93%

“…The concept that an acidic diet is associated with negative health outcomes is rampant among the public, but scientific evidence in this context remains to be consolidated and is mainly limited to the effect of DAL on bone mass and kidney stones. In fact, the effects of an acidic diet (with high PRAL values) on pathological conditions, such as hypertension, diabetes, and CV disease, are yet to be fully elucidated ( 13 , 14 ) and remain a matter of contention ( 15 – 17 ). While the MD has been widely demonstrated to elicit positive effects on cardiometabolic health ( 18 – 20 ) and may decrease DAL, it remains to identify a putative association between the MD and DAL, assessed using PRAL or NEAP.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Acid Load but Not Mediterranean Diet Adherence Score Is Associated With Metabolic and Cardiovascular Health State: A Population Observational Study From Northern Italy

et al. 2022

View full text Add to dashboard Cite

Diet plays a pivotal role in shaping the trajectory of chronic diseases. In this regard, the Mediterranean diet has been widely shown to exert beneficial effects on cardiometabolic health. On the contrary, the Western diet, which has also been reported to be an acidogenic dietary pattern, elicits detrimental effects on both metabolic and cardiovascular (CV) health. However, the role of dietary acid load (DAL) as a predictor of cardiometabolic prognosis remains to be elucidated. Thus, this study aims to compare Mediterranean diet adherence (MDA) and DAL focusing on their relationship with metabolic and CV prognosis. A total of 448 individuals aged 55–80 years were grouped depending on their MDA, assessed using food frequency questionnaires, or DAL, evaluated using potential renal load acid (PRAL) and net-endogenous acid production (NEAP). Study participants underwent anthropometric and biochemical measurements. The metabolic syndrome (MetS) prevalence was evaluated according to the National Cholesterol Education Program-Adult Treatment Panel III. Finally, the CV risk was evaluated using three independent algorithms: atherosclerotic cardiovascular disease (ASCVD), European Systematic COronary Risk Evaluation (SCORE), and Cuore risk scores. Mediterranean diet adherence was negatively associated with PRAL and NEAP. Individuals in the higher MDA tertile group had higher HDL cholesterol as well as lower homeostasis model assessment index (HOMA-IR) and fat mass relative to the lowest MDA tertile. However, in the high-MDA tertile group, there was neither a significantly lower MetS prevalence nor CV risk. Instead, both the MetS prevalence and CV risk were higher in individuals in the higher acid PRAL quartile relative to the lower alkaline PRAL quartile. Dietary acid load, especially assessed using PRAL but not MDA, was associated with indices of metabolic and CV prognosis. Thus, DAL assessed by 24-h dietary recalls may represent a better predictor of cardiometabolic health if compared to MDA evaluated using food frequency questionnaires.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Dietary Acid Load but Not Mediterranean Diet Adherence Score Is Associated With Metabolic and Cardiovascular Health State: A Population Observational Study From Northern Italy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The present study found a positive association between high DAL (NEAP score) with MetS. In line with the present findings, a cross‐sectional study by Arisawa et al on 14 042 Japanese men and 14 105 women (aged 35‐69 years) revealed higher DAL (NEAP score) was associated with a higher prevalence of MetS 28 . Iwase et al reported that higher DAL (PRAL and NEAP scores) was correlated with a higher prevalence of MetS in 149 patients with Type 2 diabetes 49 …”

Section: Discussionsupporting

confidence: 91%

“…In contrast to Farhangi et al, Wu et al showed a positive relationship between DAL and CRP 26,27 . Arisawa et al also reported that a higher acid load was associated with MetS 28 . In contrast, a study of 1430 Iranian adults found no significant association between MetS and quartiles of dietary acid load 29 …”

Section: Introductionmentioning

confidence: 89%

The association between dietary acid load with cardiometabolic risk factors and inflammatory markers amongst elderly men: A cross‐sectional study

Jafari

Ghanbari

Shahinfar

et al. 2021

Int J Clinical Practice

View full text Add to dashboard Cite

Background Existing epidemiological data on dietary acid load and cardiovascular disease (CVD) are controversial. There is no literature evaluating the association between dietary acid load (DAL) with cardiometabolic risk factors and inflammatory markers in elderly. Objective To evaluate the association between DAL and cardiometabolic risk factors amongst Iranian elders. Method A cross‐sectional study was completed using 357 Iranian elders above >60 years of age. Anthropometric, clinical, and biochemical measurements were performed. Dietary intake was assessed using a validated and reliable food frequency questionnaire. DAL was estimated using the Potential Renal Acid Load (PRAL) score, Net Endogenous Acid Production (NEAP) and the Net Endogenous Acid Excretion (NAE) score. Metabolic syndrome (MetS) was defined according to the ATP‐III criteria. Multivariable‐adjusted odds ratios (ORs) of CVD risk factors were estimated using logistic regression. Results After adjustment for confounders, a higher PRAL score was associated with higher odds of hypertriglyceridemia (OR: 2.28, 95% CI: 1.15, 4.50). We also observed that the NEAP score was positively associated with MetS (OR: 17.2, 95% CI: 2.34, 127). Finally, there was a positive association between NAE and lipid accumulation product (LAP) (OR: 1.81, 95% CI: 1.04, 3.17) and hypertriglyceridemia (OR: 2.46 95% CI: 1.22, 4.95). Conclusion Men with higher DAL scores had a higher risk of MetS, hypertriglyceridemia and LAP. Our findings suggest that further prospective studies are required to appraise DAL‐CVD risk factors in populations with varying dietary patterns.

show abstract

“…Median PRAL, NEAP F and NEAP R scores decreased significantly in the vegan intervention group ( Table 3 and Figure 1 ). These findings are of paramount importance, as a high DAL has been associated with a series of health repercussions [ 8 ], including an increased risk for cardiovascular disease [ 30 ], type-2-diabetes [ 31 ], metabolic syndrome [ 32 ], chronic kidney disease [ 33 ] and an elevated lipid accumulation product [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

A Vegan Diet Is Associated with a Significant Reduction in Dietary Acid Load: Post Hoc Analysis of a Randomized Controlled Trial in Healthy Individuals

Müller

Zimmermann-Klemd

Lederer

et al. 2021

IJERPH

View full text Add to dashboard Cite

The composition of diet strongly affects acid–base homeostasis. Western diets abundant in acidogenic foods (meat and cheese) and deficient in alkalizing foods (fruits and vegetables) increase dietary acid load (DAL). A high DAL has been associated with numerous health repercussions, including cardiovascular disease and type-2-diabetes. Plant-based diets have been associated with a lower DAL; however, the number of trials exploring this association is limited. This randomized-controlled trial sought to examine whether an isocaloric vegan diet lowers DAL as compared to a meat-rich diet. Forty-five omnivorous individuals were randomly assigned to a vegan diet (n = 23) or a meat-rich diet (n = 22) for 4 weeks. DAL was determined using potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores at baseline and after 3 and 4 weeks, respectively. After 3 weeks, median PRAL (−23.57 (23.87)) and mean NEAPR (12.85 ± 19.71) scores were significantly lower in the vegan group than in the meat-rich group (PRAL: 18.78 (21.04) and NEAPR: 60.93 ± 15.51, respectively). Effects were mediated by a lower phosphorus and protein intake in the vegan group. Our study suggests that a vegan diet is a potential means to reduce DAL, whereas a meat-rich diet substantially increases the DAL burden.

show abstract

Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study

Cited by 23 publications

References 32 publications

Dietary Acid Load but Not Mediterranean Diet Adherence Score Is Associated With Metabolic and Cardiovascular Health State: A Population Observational Study From Northern Italy

Dietary Acid Load but Not Mediterranean Diet Adherence Score Is Associated With Metabolic and Cardiovascular Health State: A Population Observational Study From Northern Italy

The association between dietary acid load with cardiometabolic risk factors and inflammatory markers amongst elderly men: A cross‐sectional study

A Vegan Diet Is Associated with a Significant Reduction in Dietary Acid Load: Post Hoc Analysis of a Randomized Controlled Trial in Healthy Individuals

Contact Info

Product

Resources

About