Abstract:IMPORTANCE Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of somatic leukemogenic variations in hematopoietic stem cells, has been associated with atherosclerotic cardiovascular disease. Because the inherited risk of developing CHIP is low, lifestyle elements such as dietary factors may be associated with the development and outcomes of CHIP. OBJECTIVE To examine whether there is an association between diet quality and the prevalence of CHIP.
DESIGN, SETTING, AND PARTICIPANTSThis retrosp… Show more
“…18 There might be an enrichment of CHIP in populations with J o u r n a l P r e -p r o o f T2DM, as previously suggested by Jaiswal et al 11 An unhealthy diet quality and a higher body mass index have also been previously associated with a higher prevalence of CHIP. 52,53 In our population, most variants were found in DNMT3A and TET2 and most individuals with CHIP carried a single mutation. These findings are in line with previously published data.…”
Section: Discussionmentioning
confidence: 80%
“… 11 An unhealthy diet quality and a higher body mass index have also been previously associated with a higher prevalence of CHIP. 51 , 52 …”
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
“…18 There might be an enrichment of CHIP in populations with J o u r n a l P r e -p r o o f T2DM, as previously suggested by Jaiswal et al 11 An unhealthy diet quality and a higher body mass index have also been previously associated with a higher prevalence of CHIP. 52,53 In our population, most variants were found in DNMT3A and TET2 and most individuals with CHIP carried a single mutation. These findings are in line with previously published data.…”
Section: Discussionmentioning
confidence: 80%
“… 11 An unhealthy diet quality and a higher body mass index have also been previously associated with a higher prevalence of CHIP. 51 , 52 …”
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
“…Outside the Mediterranean basin, certain data and experiences related to the Mediterranean diet are interesting. Longevity is a relevant advantage associated with adherence to the Mediterranean diet for a substantial part of life [ 62 , 63 ]. To address this issue in Australia, which is a country geographically and culturally quite far away from the Mediterranean area, a prospective cohort study including both Anglo-Celts and Greek-Australians was conducted in Melbourne, with the goal to evaluate whether adherence to the Mediterranean diet affected the survival of elderly people in this developed non-Mediterranean country.…”
Section: Adherence To the Mediterranean Diet And Geographic Location ...mentioning
The Mediterranean diet has emerged as a comprehensive lifestyle, including specific foods and meal composition and a set of behavioural and social features. Adherence to the Mediterranean diet has been shown to promote health and reduce the prevalence of chronic diseases. The actual implementation of the Mediterranean diet is affected by several sociocultural factors as well as geographical components. Indeed, the geographical location, such as a specific country or different areas in a country and specific latitude and climate, appears to be an important factor that may strongly affect the implementation of the Mediterranean diet or some of its principles as well as the adherence to it. Another dynamic component affecting personal nutritional choices, also regarding adherence to the Mediterranean diet and its principles, is the individual life-long trajectory of food preference and nutrition habits and awareness. In this review, we discuss the current evidence on the impact of geographical location on adherence to the Mediterranean diet.
“…TET2 deficiency can also aggravate insulin resistance in mice 69 . Metabolic stressors such as unhealthy diets have now been linked to a higher prevalence of CHIP 70,71 . Additional evidence to support the hypothesis that altered lipid and glucose metabolism often seen in individuals consuming unhealthy diets or with diabetes is linked with clonal outgrowth was seen in the Swedish Obese Subjects (SOS) study 65 .…”
Haematopoiesis is the process of blood production, essential for the continued supply of immune cells and red blood cells. However, the proliferative nature of haematopoietic stem cell (HSCs) renders them susceptible to developing somatic mutations. HSCs carrying a mutation can gain a selective advantage compared to normal HSCs and result in haematological disorders. One such disorder is termed clonal haematopoiesis of indeterminate potential (CHIP), a pre-malignant state associated with ageing, where the mutant HSCs are responsible for producing a small portion of the mature immune cells in the circulation and subsequently in tissues. People with CHIP have been shown to have an increased risk of mortality due to cardiovascular disease (CVD). Why this occurs is under rigorous investigation, but the majority of the studies to date suggest increased atherosclerosis is due to heightened inflammatory cytokine release from mutant lesional macrophages. However, given CHIP is driven by several mutations, other haematopoietic lineages can be altered to promote CVD. In this review we explore the relationship between mutations in genes causing CHIP and atherothrombotic disorders, along with potential mechanisms of enhanced clonal outgrowth and potential therapies and strategies to slow CHIP progression.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.