Association of Diabetic Retinopathy in Type II Diabetes Mellitus with Hba1c Levels: A Study

Prasad, Rajendra; Nayana., G

doi:10.9790/0853-1507114853

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Rajendra Prasad et al observed in their study that there was an increase in the severity of retinopathy with higher levels of HbA1c. 9 Our study also showed similar results and we could also specifically postulate the correlation with vision-threatening diabetic retinopathy with HbA1c levels.…”

Section: Discussionsupporting

confidence: 85%

Correlation of Hba1c With Sight-Threatening Diabetic Retinopathy (Stdr) in Type 2 Diabetes Mellitus

Kotancheri¹,

Ayoor²,

Syamanthakam³

et al. 2017

jebmh

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BACKGROUND Diabetic retinopathy is a major cause of blindness in the world with India being set to emerge as the diabetic capital of the world. Visual disability from diabetes is a significant health problem, but its morbidity is largely preventable and treatable. HbA1c (glycosylated haemoglobin) is the best indicator of glycaemic control. It has long been known to predict the incidence and progression of diabetic retinopathy. Our aim is to evaluate the correlation of STDR in type 2 diabetes mellitus with HbA1c levels. MATERIALS AND METHODS A cross-sectional study was carried out in the Department of Ophthalmology, Government Medical College, Kozhikode, among 250 randomly selected type 2 Diabetes Mellitus patients and they were grouped into STDR, non-STDR and no diabetic retinopathy based on ophthalmoscopy. HbA1c level was estimated and its correlation was analysed using SPSS software version 17.0. Association of STDR with duration of diabetes and Body Mass Index (BMI) were also studied. RESULTS Out of 250 patients studied, mean age was 58.98 with 126 males and 124 females and there was increased incidence of STDR in males. 104 patients with STDR had HbA1c value of more than 8, high incidence of STDR were noted with increasing levels of HbA1c and the correlation was statistically significant (p = 0.02). 74.1% of patients had STDR in the group with duration of diabetes 11 to 15 years, 90.90% in more than 21 years group compared to 43% in the 5 years group. Increase in duration of diabetes was found to be significantly associated with higher incidence of STDR (p = 0.01). Incidence of STDR were more in patients with normal BMI (p = 0.03). CONCLUSION Poor diabetic control as noted by high HbA1c level and longer duration of diabetes were significantly associated with sightthreatening diabetic retinopathy. Patients with STDR and high HbA1c levels have to be referred for appropriate evaluation and treatment at the earliest to prevent blindness.

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Section: Discussionsupporting

confidence: 85%

Correlation of Hba1c With Sight-Threatening Diabetic Retinopathy (Stdr) in Type 2 Diabetes Mellitus

Kotancheri¹,

Ayoor²,

Syamanthakam³

et al. 2017

jebmh

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“…Prasad et al reported mean HbA1c levels of 9.25 + 1.59 and revealed an increasing trend in the severity of retinopathy with a rise in HbA1c levels. 16 A similar study was carried out in Saudi Arabia and it concluded that patients who had uncontrolled diabetes (high HbA1c levels) had 66.61% chance of developing diabetic retinopathy. 17 Relationship between diabetic retinopathy and HbA1c levels showed that severity of retinopathy increased as HbA1c levels were raised and this is also supported by many other similar studies.…”

Section: Discussionmentioning

confidence: 85%

Relationship between HbA1c Levels and Severity of Diabetic Retinopathy

Jamshed¹,

Hanif²,

Malik³

et al. 2021

pak J Ophthalmol

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Purpose: To determine the relationship between HbA1c and severity of retinopathy in diabetic patients. Study Design: Cross sectional study. Place and Duration of Study: Eye department of DHQ-UTH Gujranwala, from July 2020 to Dec 2020. Methods: An observational cross-sectional study including 100 patients was conducted at eye department of DHQ-UTH Gujranwala from January 2018 to December 2018. After approval from institutional review board, written informed consent with demographic variables was collected from every patient. Patients of either gender between 40-80 years of age with both types I and type II diabetes were included in this study. Complete ophthalmic examination including Best Corrected Visual Acuity, slit lamp biomicroscopy, Goldmann Applanation tonometry and fundus examination carried out. Diabetic retinopathy was classified from grade 0 to grade 5. Results: Out of 100 patients, 46 (46%) were males and 54 (54%) were females. Mean age was 60 ± 2.4 years with a range of 40 – 80 years among males and 40 – 70 years among females. Forty patients presented with grade 1 diabetic retinopathy and 4% presented with grade 5. Thirty two patients had good glycemic control while 20% had glycemic control of grade III. Patients with grade 4 diabetic retinopathy had the worst glycemic control of HbA1c level of 11.5. Conclusion: This study concluded that patients with poor glycemic control had severe diabetic retinopathy as compared to the patients with good diabetic control. There is a direct relation between HbA1c level and severity of diabetic retinopathy. Key Words: HbA1C, Diabetic retinopathy, Non proliferative diabetic retinopathy, Proliferative diabetic retinopathy, Vitreous hemorrhage.

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“…Other study in Dhaka, Bangladesh-India on 80 type 2 DM patients also showed a positive correlation between RDW and HbA1c levels (r=0.45; p=0.001) (Jahan et al, 2018). Another study that compared the correlation of RDW and HbA1c levels in male (r= 0.40) and female (r= 0.04) (Jahan et al, 2018).…”

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confidence: 88%

“…RDW and HbA1c which have a positive relationship are mentioned in various studies on DM and are considered to have a role in the course of the disease and its complications. Routinely measuring RDW values can be used as a practical biomarker in assessing risk in DM patients (Jahan et al, 2018) A study in Pakistan on 119 type 2 DM patients found a positive and significant correlation berween HbA1c and RDW (r= 0.193; p= 0.035), while other hematological parameters, such as MCV, hemoglobin and platelets were not correlated with RDW (Bhutto, Abbasi and Abro, 2019).…”

mentioning

confidence: 99%

Correlation between HbA1c Levels and Red Distribution Cell Width in Type 2 Diabetes Mellitus Patients

Rahma,

Siregar,

Syafril

et al. 2024

INDONES J MED

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Background: HbA1c is used as a parameter for diagnosis and monitoring of diabetes mellitus (DM). Apart from that, HbA1c, red blood cells also experience changes which result in changes in erythrocyte structure and hemodynamic characteristics. The parameter that changes in this case is red cell distribution width (RDW). This study aimed to analyze correlation between HbA1c levels and RDW in type 2 DM patients. Subjects and Method: This a cross sectional study conducted at H. Adam Malik General Central Hospital, Medan, North Sumatera, Indonesia, from December 2022-April 2023. Total sample of 75 type 2 DM patients was selected consecutively. The dependent variable was RDW. The independent variable was HbA1c. Data of RDW and HbA1c were collected from complete blood count test. Data were analyzed using the Spearman correlation. Results: HbA1c was negatively associated with RDW, but it was statistically non-significant (r= -0.08; p= 0.508). Conclusion: HbA1c is negatively associated with RDW, but it is statistically non-significant. Keywords: diabetes melitus, HbA1c, red cell distribution width

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Association of Diabetic Retinopathy in Type II Diabetes Mellitus with Hba1c Levels: A Study

Abstract: :Purpose :To assess the association of Diabetic Rtinopathy in Type -II Diabetes Mellitus with HbA1c

Cited by 4 publications

References 9 publications

Correlation of Hba1c With Sight-Threatening Diabetic Retinopathy (Stdr) in Type 2 Diabetes Mellitus

Correlation of Hba1c With Sight-Threatening Diabetic Retinopathy (Stdr) in Type 2 Diabetes Mellitus

Relationship between HbA1c Levels and Severity of Diabetic Retinopathy

Correlation between HbA1c Levels and Red Distribution Cell Width in Type 2 Diabetes Mellitus Patients

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