Association of diabetic nephropathy with the severity of obstructive sleep apnea-hypopnea syndrome in patients with type 2 diabetes mellitus

Abstract

This study aimed to analyze the effect of the severity of obstructive sleep apnea-hypopnea syndrome (OSAHS) on diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). A total of 322 patients with T2DM participated in this cross-sectional study. OSAHS was diagnosed according to the apnea-hypopnea index (AHI) and it was categorized as follows: normal, mild, moderate, and severe. Relevant clinical data retrieved from medical charts were cross-analyzed between different groups. The relationship between urinary albumin/creatinine ratio(UACR) and OSAHS parameters, which included AHI, lowest oxygen saturation (L-SaO 2 ), and mean oxygen saturation (M-SaO 2 ), was evaluated by partial correlation analysis. DN stages were classified into a non-DN group, a microalbuminuria group, and a macroalbuminuria group. Multiple factor logistic regression analysis was employed to analyze factors influencing DN. The results showed that mild OSAHS, moderate OSAHS, and severe OSAHS patients had a higher Body mass index (BMI), creatinine (CR) level, UACR, and a longer duration of T2DM (p < 0.05) than the non-OSAHS group. The prevalence of DN in the non-OSAHS, mild OSAHS, moderate OSAHS, and severe OSAHS groups was 18.4%, 19.2%, 34.6%, and 49.4%, respectively (p < 0.05). Multiple factor logistic regression analysis revealed that systolic blood pressure (SBP) (OR = 1.03), AHI (OR = 1.02), and duration of T2DM (OR = 1.04) were correlated with DN (p < 0.05). These findings revealed that OSAHS is highly prevalent in T2DM and AHI is independently associated with the presence of DN.OBSTRUCTIVE SLEEP APNEA-HYPOPNEA SYN-DROME (OSAHS) is characterized by the collapse of the upper airway, which leads to hypoxemia and sleep fragmentation. The main symptoms of OSAHS include interval snoring, periods of stopped breathing and waking up during sleep, sweating and excessive urine at night, dizziness and headache in the morning, and daytime fatigue and sleepiness. The prevalence of OSAHS was estimated to be 2-4% in 2004 [1], which increased with increasing age and diagnostic levels. Currently, the mean prevalence of OSAHS among male was 22% (9-37%), while it was 17% (4-50%) among female [2]. However, the majority of OSAHS cases have not been diagnosed and treated in a timely and effective manner.Type 2 diabetes mellitus (T2DM) is a major public health problem due to high rates of morbidity, mortality,

Plasma tRF-16-79MP9PD and tRF-28-OB1690PQR304 as potential biomarkers for 4- to 7-year-old children with obstructive sleep apnea-hypopnea syndrome

“…The results showed that the height of children with OSAHS was lower than that of HC group, which was consistent with the research of Johnson C ( 29 ) and may due to the decrease of growth hormone secretion caused by poor sleep quality of children with OSAHS. Similarly, the two groups had statistical differences in Scr and TC, which was consistent with the studies of other scholars ( 30 , 31 ). Secondly, we performed small RNA sequencing to detect the expression profile of tRFs in 5 pairs of OSAHS children and control specimens.…”

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“…OSA is found in 30–60% of patients with heart failure, 42% of patients with ischemic stroke, 85% of patients with atrial fibrillation [ 5 ], 41.89% of patients with hypertension [ 6 ] and 57.69% of patients with hypertensive emergencies [ 7 ]. A study from China found that the prevalence of OSA in admitted Type 2 diabetes mellitus patients was 60.0% [ 8 ], while patients with Type 2 diabetes mellitus who had diabetic nephropathy had an even higher prevalence of OSA, at 88.2% [ 9 ].…”