Association of Diabetic Autonomic Neuropathy with Red Blood Cell Aldose Reductase Activity

Gupta, Pawan Kumar; Verma, Narsingh; Bhattacharya, Sandeep; Mahdi, Abbas Ali; Usman, Kauser; Tiwari, Sunita; Bhardwaj, Kshitij

doi:10.1016/j.jcjd.2013.07.021

Cited by 7 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulation of sorbitol has been shown to increase the formation of advanced glycation end products, which may increase oxidative stress and impair function 161,162 . For instance, in patients with diabetes, accumulation of sorbitol due to increased activity of the enzyme aldose reductase has been associated with the development of diabetic autonomic neuropathy 163 …”

Section: The Map Of Erythrocyte Metabolismmentioning

confidence: 99%

Erythrocyte metabolism

Chatzinikolaou,

Margaritelis,

Paschalis

et al. 2024

Acta Physiologica

View full text Add to dashboard Cite

Our aim is to present an updated overview of the erythrocyte metabolism highlighting its richness and complexity. We have manually collected and connected the available biochemical pathways and integrated them into a functional metabolic map. The focus of this map is on the main biochemical pathways consisting of glycolysis, the pentose phosphate pathway, redox metabolism, oxygen metabolism, purine/nucleoside metabolism, and membrane transport. Other recently emerging pathways are also curated, like the methionine salvage pathway, the glyoxalase system, carnitine metabolism, and the lands cycle, as well as remnants of the carboxylic acid metabolism. An additional goal of this review is to present the dynamics of erythrocyte metabolism, providing key numbers used to perform basic quantitative analyses. By synthesizing experimental and computational data, we conclude that glycolysis, pentose phosphate pathway, and redox metabolism are the foundations of erythrocyte metabolism. Additionally, the erythrocyte can sense oxygen levels and oxidative stress adjusting its mechanics, metabolism, and function. In conclusion, fine‐tuning of erythrocyte metabolism controls one of the most important biological processes, that is, oxygen loading, transport, and delivery.

show abstract

Section: The Map Of Erythrocyte Metabolismmentioning

confidence: 99%

Erythrocyte metabolism

Chatzinikolaou,

Margaritelis,

Paschalis

et al. 2024

Acta Physiologica

View full text Add to dashboard Cite

show abstract

“…High glucose concentration in plasma, also called hyperglycemia, as can be observed in diabetes, can have many effects on erythrocytes [17]. For instance, glucose can be metabolized in the erythrocyte by aldose reductase leading to sorbitol or fructose production through the polyol pathway, which can lead to complications like diabetic neuropathy [18]. Hyperglycemia also leads to glycation of hemoglobin.…”

Section: Communication Between Erythrocytes and Other Cells Takes Pla...mentioning

confidence: 99%

Erythrocytes as Messengers for Information and Energy Exchange between Cells

Johansson¹,

Falk²

2023

The Erythrocyte - A Unique Cell

View full text Add to dashboard Cite

Evolution has created a hierarchy of systems for information and energy using different cells according to messages generated from DNA, RNA, and other sources. Erythrocytes are formed in high speed at about 2 × 106/s to balance dying or not working erythrocytes to maintain optimal energy and information transfer. Important information is handled by nucleotides and distribution of metal ions and phosphates when starting synthesis process. Handling of these processes needs kinases known to be magnesium-dependent. Oxygen delivered by erythrocytes is used by other cells to synthesize ATP and to increase reaction capacity. Complex signals to bone marrow balance erythroblasts before developing into reticulocytes and erythrocytes. We discuss some aspects of erythrocyte communication with other cells of the body with special focus on magnesium and selenium in this process.

show abstract

“…In the polyol pathway, glucose is reduced to sorbitol by AR and then oxidized to fructose by sorbitol dehydrogenase, resulting in the accumulation of sorbitol and fructose [72]. Gupta [73] showed that high AR activity and sorbitol concentration played important roles in the pathogenesis of autonomic neuropathy in patients with T2DM. Nitric oxide (NO) produced by erythrocytes is involved in the cell deformation in the microcirculation, and the decreased NO bioavailability in erythrocytes leads to their decreased deformability and increased adhesion, resulting in microcirculation disorders [74,75].…”

Section: Fluiditymentioning

confidence: 99%

The Relationship between Erythrocytes and Diabetes Mellitus

Wang

Yang

Zhou

et al. 2021

Journal of Diabetes Research

View full text Add to dashboard Cite

High blood glucose level (hyperglycemia) is a leading indicator of diabetes mellitus (DM). Erythrocytes are the most abundant cells in the circulation and the first to perceive changes in plasma composition. Long-lasting hyperglycemia affects the structure and function of erythrocytes. The detection of erythrocyte-related indicators can provide a valuable reference for the prevention, diagnosis, and treatment of DM and its complications. This paper reviews the normal structure and function of erythrocytes, the changes in erythrocytes in patients with diabetes, and the role of erythrocytes in the development of diabetic complications to provide more indicators for the early prevention of DM complications and to monitor the therapeutic effect of DM.

show abstract

Association of Diabetic Autonomic Neuropathy with Red Blood Cell Aldose Reductase Activity

Abstract: High aldose reductase activity is associated with the presence of autonomic neuropathy in subjects of type 2 DM.

Cited by 7 publications

References 18 publications

Erythrocyte metabolism

Erythrocyte metabolism

Erythrocytes as Messengers for Information and Energy Exchange between Cells

The Relationship between Erythrocytes and Diabetes Mellitus

Contact Info

Product

Resources

About