Association of Diabetes Mellitus and Mild Cognitive Impairment in Middle-Aged Men and Women

Winkler, Angela; Dlugaj, Martha; Weimar, Christian; Jöckel, Karl‐Heinz; Erbel, Raimund; Dragano, Nico; Moebus, Susanne

doi:10.3233/jad-140696

Cited by 41 publications

(31 citation statements)

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“…The association between T2DM and AD was not observed in one study with very old T2DM subjects (≥80 years old) (48). The association between T2DM and AD was probably specific with the age at onset of T2DM as the same relationship was observed between the age at onset of T2DM and MCI (72). Although the cortical atrophy in T2DM was reported to resemble the pattern as in preclinical AD [19], the presence of T2DM does not affect amyloid and neurofibrillary tangle burden in a sample of clinically and pathologically confirmed AD cases [84].…”

Section: T2dm As a Risk Factor For Admentioning

confidence: 56%

“…Older age (>75 years) and long duration of diabetes are major risk factors for converting MCI to dementia, while the use of oral hypoglycemic agents or statins was associated with a significantly reduced risk for converting MCI to dementia [74]. T2DM has been found to be associated with MCI or MCI subtypes in middle-aged (50-65 years old) subjects but not in elderly individuals (66-80 years old) [72]. However, T2DM was shown to be associated with an increased risk of MCI in an elderly group of subjects (70 years and older) in another study [75].…”

Section: T2dm and MCImentioning

confidence: 99%

“…Age [69,70], blood pressure [69], body mass index (BMI) [71], gender [72], current smoking status [27, 67,71], duration of diabetes [67,71,73], fasting blood glucose (FBG) [67], HbA1c [67,71], high-density lipoprotein cholesterol [71], immunoreactive insulin [67], total cholesterol [71], and triglycerides [71] were involved in developing MCI in T2DM patients. Age, education, and systolic blood pressure were significantly associated with an increased risk of MCI in older patients with T2DM [69].…”

Section: T2dm and MCImentioning

confidence: 99%

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An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia

Huang

2016

JAD

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With the rapidly expanding evidence on brain structural and functional changes in type 2 diabetes mellitus (T2DM) patients, there is an increasing need to update our understanding on how T2DM associates with dementia as well as the underlying pathophysiological mechanisms. A literature search of T2DM and dementia or cognition impairments was carried out in electronic databases Medline, EMBASE, and Google Scholar. In this review, the chosen evidence was limited to human subject studies only, and data on either type 1 diabetes mellitus (T1DM) or non-classified diabetes were excluded. T2DM is a risk factor for both vascular dementia (VaD) and Alzheimer's disease (AD), although AD pathological marker studies have not provided sufficient evidence. T2DM interacts additively or synergistically with many factors, including old age, hypertension, total cholesterol, and APOE 4 carrier status for impaired cognition functions seen in patients with T2DM. In addition, comorbid T2DM can worsen the clinical presentations of patients with either AD or VaD. In summary, T2DM increases the risk for AD through different mechanisms for VaD although some mechanisms may overlap. Tau-related neurofibrillary tangles instead of amyloid-␤ plaques are more likely to be the pathological biomarkers for T2DM-related dementia. Degeneration of neurons in the brain, impaired regional blood supply/metabolism, and genetic predisposition are all involved in T2DM-associated dementia or cognitive impairments.

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Section: T2dm As a Risk Factor For Admentioning

confidence: 56%

Section: T2dm and MCImentioning

confidence: 99%

Section: T2dm and MCImentioning

confidence: 99%

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An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia

Huang

2016

JAD

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“…The following definitions were used for exclusion of participants based on cognitive impairment, clinically relevant depressive symptoms, and dementia. Cognitive impairment at t1 was defined as a performance of one standard deviation (SD) below the age‐ and education‐adjusted mean except for the clock‐drawing test, where a performance ≥3 was rated as impaired (for a detailed description, see the study by Winkler et al [15]). A Center for Epidemiologic Studies Depression scale score of ≥18 was defined as clinically relevant depressive symptoms (CES‐D, see 2.5 [16]).…”

Section: Methodsmentioning

confidence: 99%

Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women

Müller-Gerards

Weimar

Abramowski

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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Introduction Possible joint effects of subjective cognitive decline (SCD) and apolipoprotein E ( APOE ) ε4 genotype on incident mild cognitive impairment (MCI) were examined for men and women separately. Methods Cognitively normal participants with and without SCD were included from the first follow-up examination of the population-based Heinz Nixdorf Recall study. Sex-stratified logistic regression models estimated main effects and interactions (additive, multiplicative) of SCD at the first follow-up (yes+/no−) and APOE ε4 (positive+/negative−) groups for MCI 5 years later. Results Odds for MCI 5 years later were higher in SCD/ APOE ε4 group +/+ than the sum of groups +/− and −/+ in women, with a trend for positive interaction. Odds for incident MCI in men was highest in group +/−, with no interaction effect. Discussion Our findings indicate that APOE ε4 may play an important role in the association of SCD and incident MCI, especially considering sex. Further studies need to examine these associations with larger sample sizes.

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“…Literature suggests there is a correlation between type 2 diabetes and mood alterations such as depression and neuropsychiatric disorders; for instance, major depressive disorder 10, 11 , schizophrenia 12, 13 , mild cognitive impairment 14, 15 and suicidal behavior 16 . It also has been observed that depression could cause an increase in all-cause mortality risk (approximately 70%) 17 ; it is also the most common mental disorder and generates a great impact on people and society in terms of suffering, disability and economic costs, a phenomenon that seems to occur in many parts of the world; in this context, it has been reported that depression affects 350 million people worldwide 18 ; for example, a research by Talbot et al suggests that depression is not only a direct consequence of diabetes; depression may also be a risk factor for the onset of diabetes type 2 19 .…”

Section: Introductionmentioning

confidence: 99%

Association between obesity and depression in patients with diabetes mellitus type 2; a study protocol

et al. 2015

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Background: Diabetes mellitus and depression are highly prevalent conditions throughout the world and have significant impact on health outcomes. It has been estimated that diabetes mellitus type 2 affects about 246 million people in the world; nevertheless, incidence varies among countries. There is evidence that depression is associated with a poor metabolic control in patients with type 2 diabetes mellitus that present other health problems (such as hypertension and obesity). The aim of this study protocol is to determine if obesity increases the risk for depression in patient with diabetes type 2. Methods: The analysis will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).The studies suitable for inclusion will be assessed by the Newcastle-Ottawa Scale (NOS) to determine their methodological quality. To identify the studies of interest, we will search on PubMed and EBSCO databases. We will use the following keyword combinations: "Diabetes Mellitus type 2 AND obesity AND depression", "depression AND Diabetes Mellitus type 2", "Diabetes Mellitus type 2 AND body mass index cross sectional study", "depression AND obesity cross-sectional study". Causes for exclusion will be publications that studied patients diagnosed with diabetes mellitus type 1; articles that focused on the treatment and complications of diabetes mellitus type 2; publications that have studied other clinical or psychiatric conditions (for instance, seizure disorder or history of schizophrenia, bipolar disorder, psychotic symptoms or dementia). Conclusion: The results of this study will form the basis for a better understanding of the association between obesity and depression in patients with diabetes mellitus type 2, and will allow development of prediction tools and better interventions. It is evident that several modifiable and non-modifiable risk factors play an important role in the pathogenesis of diabetes among population. Currently, evidence for the deleterious effects of diabetes mellitus type 2 are based on cross-sectional or other observational designs. Therefore, this study will have important implications for future research and public health guidance.

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Association of Diabetes Mellitus and Mild Cognitive Impairment in Middle-Aged Men and Women

Abstract: Our data show that T2DM is associated with MCI and MCI subtypes in middle-aged, but not in old-aged participants. Furthermore, the results indicate a gender-specific vulnerability of T2DM on cognition, especially in MCI subtypes.

Cited by 41 publications

References 0 publications

An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia

An Update on Type 2 Diabetes Mellitus as a Risk Factor for Dementia

Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women

Association between obesity and depression in patients with diabetes mellitus type 2; a study protocol

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