Association of Diabetes and Hypertension With Brain Structural Integrity and Cognition in the Boston Puerto Rican Health Study Cohort

Self Cite

mentioning

confidence: 95%

Author Response: Association of Diabetes and Hypertension With Brain Structural Integrity and Cognition in the Boston Puerto Rican Health Study Cohort

Koo¹,

Yi²

2023

Self Cite

“…The research by Guan et al 1 reports that older patients with type 2 diabetes (T2D) and hypertension (HTN) comorbidity presented with increased brain structural change and advanced cognitive impairment. I have a few comments.…”

mentioning

confidence: 99%

Reader Response: Association of Diabetes and Hypertension With Brain Structural Integrity and Cognition in the Boston Puerto Rican Health Study Cohort

Kawada¹

2023

“…In summary, common vascular risk factors such as diabetes and hypertension have important downstream consequences on many aspects of health. Guan et al 4 provide convincing evidence that cognition is yet another area in which these diseases are impactful and show that these disorders differentially affect specific communities. Future work will need to characterize the sources of the disparity in vascular risk factors and explore steps that can be taken to ameliorate those differences in risk.…”

mentioning

confidence: 99%

“…In this issue of Neurology ® , Guan et al 4 investigate the relationship between hypertension and diabetes in Puerto Rican residents in the Boston area and the development of cognitive impairment. One hundred ninety-two individuals from the Boston Puerto Rican Health Study (BPRHS), a community cohort study investigating health disparities among Puerto Ricans living in the greater Boston area, were stratified in a 4 × 4 factorial design according to the presence of hypertension, diabetes, both, or neither.…”

mentioning

confidence: 99%

“…These differences in brain anatomy were associated with a decline in frontal executive function and global cognitive function when education status was taken into account. Guan et al 4 then compared their BPRHS cohort to a non-Hispanic White population from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a multicenter study of individuals with mild cognitive impairment designed to determine factors leading to the development of future Alzheimer disease. 5 The individuals with hypertension and diabetes from the BPHRS cohort had a similar decline in hippocampal volume and cognitive function compared to those who had mild cognitive impairment who eventually developed Alzheimer disease within the ADNI group.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Vascular Risk Factors and Cognition in Individuals From Puerto Rico

Lee

Hamilton

2022

It has long been understood that cerebrovascular disease is a major contributor to the development of cognitive impairment. Correspondingly, mounting evidence indicates that risk factors for cerebrovascular disease are also associated with the development of cognitive deficits. For instance, hypertension and diabetes have been shown to increase the risk of developing Alzheimer disease, and cognitive decline more broadly, by inducing ultrastructural changes and ischemic injury to brain structures.1 Unfortunately, these risk factors are often disproportionately represented among persons from certain marginalized racial and ethnic groups. Notably, individuals from Puerto Rico have been shown to have a higher incidence of conditions such as diabetes and hypertension than non-Hispanic White persons or other North American Hispanic populations.2,3 However, despite the disproportionate burden that vascular disease has on some minoritized populations, most studies that have examined the interaction between vascular risk factors and cognition have focused on White, non-Hispanic populations, contributing to an incomplete understanding of how cerebrovascular risk factors and cognition interact in boarder, more diverse populations.