2019
DOI: 10.2337/dc18-2472
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Association of Diabetes and Glycated Hemoglobin With the Risk of Intracerebral Hemorrhage: A Population-Based Cohort Study

Abstract: To examine the association of diabetes and glycated hemoglobin (HbA 1c) with the risk of intracerebral hemorrhage (ICH) in a large population-based cohort. RESEARCH DESIGN AND METHODS The computerized database of the largest health care provider in Israel was used to identify adult members aged 40 years or older and alive at 1 January 2010 (297,486 with diabetes and 1,167,585 without diabetes). The cohort was followed until 31 December 2017 for incidence of ICH. Multivariable Cox proportional hazards regressio… Show more

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Cited by 43 publications
(34 citation statements)
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References 24 publications
(25 reference statements)
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“…Our finding confirms a recent large population‐based cohort study from Israel, where people with diabetes had a significantly higher risk of haemorrhagic stroke compared to the general population, which was mostly driven by glycaemic exposure and diabetes duration . Interestingly, a J‐shaped relationship between HbA1c and haemorrhagic stroke was observed in the same study, suggesting an association between extreme intensive glycaemic control and the risk of haemorrhagic stroke . In the present study, there was a small, but non‐significant J‐shaped association between HbA1c levels and excessive risk of stroke.…”
Section: Discussionsupporting
confidence: 91%
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“…Our finding confirms a recent large population‐based cohort study from Israel, where people with diabetes had a significantly higher risk of haemorrhagic stroke compared to the general population, which was mostly driven by glycaemic exposure and diabetes duration . Interestingly, a J‐shaped relationship between HbA1c and haemorrhagic stroke was observed in the same study, suggesting an association between extreme intensive glycaemic control and the risk of haemorrhagic stroke . In the present study, there was a small, but non‐significant J‐shaped association between HbA1c levels and excessive risk of stroke.…”
Section: Discussionsupporting
confidence: 91%
“…Even though the event rate was much smaller for haemorrhagic stroke than ischaemic stroke, the association between glycaemic control and stroke types reflected each other, demonstrating the importance of glycaemic control regardless of stroke type . Our finding confirms a recent large population‐based cohort study from Israel, where people with diabetes had a significantly higher risk of haemorrhagic stroke compared to the general population, which was mostly driven by glycaemic exposure and diabetes duration . Interestingly, a J‐shaped relationship between HbA1c and haemorrhagic stroke was observed in the same study, suggesting an association between extreme intensive glycaemic control and the risk of haemorrhagic stroke .…”
Section: Discussionsupporting
confidence: 86%
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“…A record is kept of the data sources and dates used to establish the diagnosis, with the earliest recorded date, from any source, considered to be the defining date of diagnosis. A number of high quality, population based studies have been conducted based on the data retrieved from the CHS database …”
Section: Methodsmentioning
confidence: 99%