Association of developmental coordination disorder with early-life exposure to fine particulate matter in Chinese preschoolers

Cai, Jing; Shen, Yang; Meng, Xia; Zhao, Yan; Niu, Yue; Chen, Renjie; Du, Wenchong; Quan, Guangbin; Barnett, Anna; Jones, G.W.; Kan, Haidong; Hua, Jing

doi:10.1016/j.xinn.2022.100347

Cited by 6 publications

(4 citation statements)

References 55 publications

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“…Meanwhile, for certain compounds, direct air-to-skin dermal uptake is comparable to the inhalation intake, imposing a significant burden on human health. 417 , 418 , 419 , 420 , 421 , 422 , 423 , 424…”

Section: Risks Of Ecs To Planetary Healthmentioning

confidence: 99%

Emerging contaminants: A One Health perspective

Wang,

Xiang,

Sze-Yin Leung

et al. 2024

The Innovation

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Section: Risks Of Ecs To Planetary Healthmentioning

confidence: 99%

Emerging contaminants: A One Health perspective

Wang,

Xiang,

Sze-Yin Leung

et al. 2024

The Innovation

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“…PM 2.5 exposure may elevate the risk of SDDs in both sexes (RR: 1.52, 95% CI: 1.19, 2.03, per 10 μg/m 3 increase in PM 2.5 exposure), particularly in problem-solving skills among girls (RR: 2.23, 95% CI: 1.22, 4.35) [ 37 ]. Information gathered from a cohort study including 109,731 children between the ages of 3 and 5 years in China suggested that exposure to PM 2.5 during prenatal and postnatal stages was linked to diminished motor performance and greater risk of DCD [ 38 ]. The aOR was 1.06 (95% CI: 1.01, 1.10) and 1.06 (95% CI: 1.01, 1.13) for every interquartile range elevation in PM 2.5 exposure during the first 3 months and the initial 3 years, separately.…”

Section: Neurodevelopmental Toxicity Caused By Pm 25mentioning

confidence: 99%

Developmental Toxicity of Fine Particulate Matter: Multifaceted Exploration from Epidemiological and Laboratory Perspectives

Yan,

Ma,

Liu

et al. 2024

Toxics

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Particulate matter of size ≤ 2.5 μm (PM2.5) is a critical environmental threat that considerably contributes to the global disease burden. However, accompanied by the rapid research progress in this field, the existing research on developmental toxicity is still constrained by limited data sources, varying quality, and insufficient in-depth mechanistic analysis. This review includes the currently available epidemiological and laboratory evidence and comprehensively characterizes the adverse effects of PM2.5 on developing individuals in different regions and various pollution sources. In addition, this review explores the effect of PM2.5 exposure to individuals of different ethnicities, genders, and socioeconomic levels on adverse birth outcomes and cardiopulmonary and neurological development. Furthermore, the molecular mechanisms involved in the adverse health effects of PM2.5 primarily encompass transcriptional and translational regulation, oxidative stress, inflammatory response, and epigenetic modulation. The primary findings and novel perspectives regarding the association between public health and PM2.5 were examined, highlighting the need for future studies to explore its sources, composition, and sex-specific effects. Additionally, further research is required to delve deeper into the more intricate underlying mechanisms to effectively prevent or mitigate the harmful effects of air pollution on human health.

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“…Various prenatal exposures, such as environmental pollutants, smoking, and alcohol have been associated with an increased risk of DCD [ 94 , 95 ]. A national retrospective cohort study conducted in China revealed that ambient PM2.5 exposure during pregnancy and the first 3 years of life is a significant contributor to an elevated risk of DCD [ 96 ]. The potential long-term effects of air pollution on children’s neurodevelopment are not yet fully understood.…”

Section: Advances In Epigenetics Of Dcd and Its Comorbiditymentioning

confidence: 99%

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

et al. 2023

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Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition’s aetiology.

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Association of developmental coordination disorder with early-life exposure to fine particulate matter in Chinese preschoolers

Cited by 6 publications

References 55 publications

Emerging contaminants: A One Health perspective

Emerging contaminants: A One Health perspective

Developmental Toxicity of Fine Particulate Matter: Multifaceted Exploration from Epidemiological and Laboratory Perspectives

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

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