Association of depression with 10-year poststroke mortality

Morris, Philip; Robinson, Robert G.; Andrzejewski, P.; Samuels, Jack; Price, Thomas R.

doi:10.1176/ajp.150.1.124

Cited by 411 publications

(50 citation statements)

References 24 publications

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“…PSD can significantly affect the functional recovery of the patient [44], the process of social and family reintegration and survival [45], and can increase the risk of future recurrence of adverse vascular events [14, 40]. As such, it is fundamental to know these complications and to detect them as early as possible so as to initiate antidepressant therapy.…”

Section: Impact Of Depression On the Clinical Evolution Of The Strokementioning

confidence: 99%

“…The association between PSD and long-term mortality risk has been investigated, the increased risk being independent of other factors such as gender, age, social class, stroke type, site of lesion, comorbidity and functional recovery of the patient [45, 46, 57]. Also, there appears to be a special vulnerability of the depressed patient in social isolation.…”

Section: Impact Of Depression On the Clinical Evolution Of The Strokementioning

confidence: 99%

“…Pharmacological treatment (fig. 1), with remission of the depression symptoms, is associated with a better functional recovery than nontreatment [44, 45, 48, 62]. A recent meta-analysis concluded that the use of antidepressants over a long period in patients diagnosed as having PSD is associated with a reduction in the symptoms of depression [63].…”

Section: Treatment Of Psdmentioning

confidence: 99%

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Poststroke Depression: Importance of Its Detection and Treatment

Gabaldón¹,

Fuentes²,

Frank-García³

et al. 2007

Cerebrovasc Dis

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Background: Poststroke depression (PSD) is a complication that occurs in up to 30% of the patients who have had a stroke. Its development is associated with a poor functional prognosis and a negative impact on the patient’s quality of life. Methods: In the present review, we summarize the diagnostic criteria, prevalence, predisposing factors, the lesion site, the impact of PSD on the clinical evolution of the patient, the current therapeutic approaches and even the relationship between depression and cerebrovascular disease. Results: There are differences in relation to prevalence, essentially due to the use of different diagnostic criteria. Also, there have been few studies focusing on the search for factors that are predictive of PSD (age, female sex, single vascular lesion independent of site) and the reluctance to initiate preventive treatments to minimize the effects on the clinical evolution of the patients. There have been several advances with respect to the treatment of PSD. It seems that treatments show improvement trends, but today there is not enough evidence to recommend a preventive therapy for depression in any stroke patient. Conclusions: We consider that the prevalence of PSD is relevant and that the risk factors as well as the early diagnosis are important for the best management and prognosis of stroke patients. Further studies are needed in this field in order to reduce PSD.

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Section: Impact Of Depression On the Clinical Evolution Of The Strokementioning

confidence: 99%

Section: Impact Of Depression On the Clinical Evolution Of The Strokementioning

confidence: 99%

Section: Treatment Of Psdmentioning

confidence: 99%

See 1 more Smart Citation

Poststroke Depression: Importance of Its Detection and Treatment

Gabaldón¹,

Fuentes²,

Frank-García³

et al. 2007

Cerebrovasc Dis

View full text Add to dashboard Cite

show abstract

“…Outcome after stroke is well documented in numerous studies [1,2,3,4,5,6,7], and several prognostic determinants such as age, diabetes, hypertension, physical inactivity, cardiac disease, recurrent stroke, stroke subtype, stroke unit care, depression and stroke severity have been identified. However, the starting point has most often been the time of the stroke.…”

Section: Introductionmentioning

confidence: 99%

Functional Outcome 3 Months after Stroke Predicts Long-Term Survival

et al. 2008

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Background: When reporting stroke survival and prognostic factors with a possible effect on outcome, the starting point for the observation of a clinical cohort usually is the onset of stroke or the acute admission of a patient. Thus, acute and early mortality inflict prognosis on long-term outcome. In order to give a more robust analysis of long-term survival after the acute period we chose to start our observation with 3-month survivors. Methods: We used data from Riks-Stroke, the Swedish quality register for stroke care, together with survival information from the Swedish population register to explore the influence of disability level 3 months after stroke on long-term survival. The main analysis included 15,959 stroke patients, registered during 2001–2002, who had been independent in primary activities of daily living before stroke, had suffered an ischaemic or a haemorrhagic stroke and reported no previous stroke. Results: Impaired functional outcome after stroke was an independent predictor of poor survival. Patients with modified Rankin scale (mRS) grades 3, 4 and 5 had hazard ratios of 1.7, 2.5 and 3.8, respectively, as compared with patients with lower mRS grades. In addition to high mRS, male sex, high age, diabetes, smoking, hypertension therapy at stroke onset, atrial fibrillation and depressed mood were also recognized as significant predictors of poor survival using a multiple Cox regression model. Conclusion: The influence of disability on survival is stronger than that of several other well-known prognostic factors. This finding indicates that any intervention in the acute phase that may improve functional status at 3 months will also have favourable secondary effects on survival in the long term.

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“…Comorbid psychiatric disorders also affect the outcome of the medical disorder and the healthcare costs of medical patients [2]. As an example, it has been reported that depression following stroke and myocardial infarction is associated with an increased risk of subsequent mortality [3, 4]. Although authors engaged in psychiatric aspects of dermatologic disorders commonly report about the psychosomatic basis of skin diseases and the personality of the patients with skin diseases, the relationship between psychologic factors and skin diseases has not been well defined yet.…”

Section: Introductionmentioning

confidence: 99%

Psychiatric Disorders in Patients Attending a Dermatology Outpatient Clinic

1998

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Background: Psychiatric comorbidity in patients with skin disorders has been reported. Objective: To find out the prevalence of psychiatric disorders in dermatology outpatients and to investigate the factors that affect the psychiatric symptoms. Methods: 256 patients attending our dermatology outpatient clinic completed a 12-item General Health Questionnaire (GHQ) following their dermatologic examination. A standardized personal interview was performed to establish a psychiatric diagnosis in patients sampled by using a stratified random sampling method. Results: The prevalence of psychiatric disorders was found to be 33.4% in the study group. The mean of the total GHQ scores of the sample group (n = 256 patients) was 3.656. The duration of the dermatologic complaints, sex of the subjects, localization of the lesions, and dermatologic diagnosis did not affect the total GHQ scores of the patients. Conclusion: Psychiatric comorbidity in 33.4% of the dermatology outpatients indicates the need for considering emotional factors for an effective management of the cutaneous disorders.

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Association of depression with 10-year poststroke mortality

Abstract: These results indicate that depressed mood following stroke is associated with an increased risk of subsequent mortality. Patients who are depressed and socially isolated seem to be particularly vulnerable.

Cited by 411 publications

References 24 publications

Poststroke Depression: Importance of Its Detection and Treatment

Poststroke Depression: Importance of Its Detection and Treatment

Functional Outcome 3 Months after Stroke Predicts Long-Term Survival

Psychiatric Disorders in Patients Attending a Dermatology Outpatient Clinic

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