“…In addition, there are interactions between strontium and calcium and among copper, molybdenum, and sulfur with manganese possibly antagonizing the interaction between copper and molybdenum (Underwood, 1977). Interactions between magnesium and carbonates, phosphates, fluoride, barium, calcium, and strontium have also been proposed (Featherstone, 19831, and it has been suggested that water hardnesses (Adler and Straub, 1953;Bowen et al, 1977;East, 1941) and water buffering capacities (Bowen et al, 1977) affect caries incidences. Therefore, it is essential that multiple geochemical factors and their combinations be considered in studies of etiologies of dental diseases; yet it has been only recently that the necessary analytical and statistical techniques have become commonly available.…”