Association of Decreased High-Density Lipoprotein Cholesterol (HDL-C) With Obesity and Risk Estimates for Decreased HDL-C Attributable to Obesity

Bora, Kaustubh; Pathak, Mauchumi Saikia; Borah, Probodh; Das, Dulmoni

doi:10.1177/2150131916664706

Cited by 21 publications

(13 citation statements)

References 19 publications

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“…In the research of abdominal adipose tissue and serum HDL-cholesterol, Despres suggested body fat topography and serum HDL was positively associated [24] . Bora has been found people with central obesity had signi cantly greater odds of developing decreased serum HDL level [25] , and similar results was showed in Canterin's study (Obese subjects have lower aerum HDL cholesterol level) [26] . Rodriguez et al conducted one study on the association of hepcidin with triglyceride-rich lipoprotein dyslipoproteinemia, small dense LDL and insulin resistance in adolescents, and results showed major changes in adolescents with obesity [27] .…”

Section: Discussionsupporting

confidence: 73%

Visceral Fat is Better Related To Liver Function and Lipid Metabolism Than Body Mass Index and Waist Circumference: A Cross-Sectional Study

Zhou¹,

Sun²,

Pan

et al. 2021

Preprint

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Objective: The role of visceral fat area (VFA) in the metabolism of lipid and liver function was not known. To compare and evaluate the correlation of VFA, waist circumference (WC) and Body mass index (BMI) measured by Bioelectrical impedance (BIA) in terms of lipid metabolism and liver function. Receiver operating characteristic curve (ROC curve), optimum cut-off points and odds ratio (OR) for liver function and lipid metabolism variables were recommended.Methods: A cross-sectional study was conducted on the subjects with the diagnose of obesity, including normal, overweight and obesity groups Direct Segmental Multi-Frequency Biolectrical Impedance technology was used to analysze body composition and biochemical indicators were tested. Participants were divided into normal and unnormal groups by lipid and liver indicators, cut off value of VFA and related variables was calculated by ROC analysis and multiple logistic regression analysis were conducted. Results: Ninety-five participants were enrolled in this study, fifty-seven (60%) were male, and the average age was thirty-four years old. Compared with normal group, high density lipoprotein (HDL) and low density lipoprotien (LDL) disorder groups have a higher VFA (normal HDL group 87.3cm2< unnormal HDL group 115.8cm2; normal LDL group 90.5cm2< unnormal LDL group 109.0cm2, p<0.05). VFA was higher in the lactate dehydrogenase (LDH) disorder group than in the normal, and the difference was significant (144.6cm2>96.2cm2, p=0.016). BMI, WC and VFA values was manifested positively correlated to glutamic oxaloacetic transaminase (AST) and alanine aminotransferase (ALT), respectively. Area under the curve (AUC) of VFA was over than 0.7 revealed great ability of related to lipid HDL metabolism (p=0.004). VFA (AUC= 0.701, 95% CI 0.577-0.826, p =0.004) provides a better diagnostic accuracy to distinguish between HDL disorder and normal groups. The optimal cut-off value for VFA was 80.2cm2 with 81.3% sensitivity and 56.8% specificity. For LDH disorder, a cut-off value of VFA 125.3 cm2 shows a sensitivity of 83.3% and specificity of 78.9% (AUC=0.792, 95% CI 0.595-0.989, p=0.019). The risk of lipid metabolism disorder and liver dysfunction were explored, and Multivariate analysis showed that VFA>80.2cm2 (OR=2.81, p=0.034) was a significantly risk factor related to HDL disorder and VFA>125.3cm2 (OR=18.75, P=0.01) was the risk factor for LDH disorder. While, WC and BMI wasn’t in the regression equation.Conclusion: VFA was more reliable and related to the lipid metabolism and liver function. VFA could be used as an independent indicator for the evaluation of the risk lipid metabolism disorder and liver dysfunction.

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Section: Discussionsupporting

confidence: 73%

Visceral Fat is Better Related To Liver Function and Lipid Metabolism Than Body Mass Index and Waist Circumference: A Cross-Sectional Study

Zhou¹,

Sun²,

Pan

et al. 2021

Preprint

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“…A decrease in HDL and an increase in LDL are associated with obesity. Plasma levels of sTNF-R1, TNFSF12, TNFSF13, TNFSF13B positively correlated with HDL levels and negatively correlated with LDL levels [17].…”

Section: Discussionmentioning

confidence: 86%

Tumour Necrosis Receptor Superfamily Interact with the Mitochondrial Dynamics in Adipose Tissue in Obese Patients without Type 2 Diabetes

Skuratovskaia¹,

Komar²,

Vulf³

et al. 2021

Preprint

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Interactions between receptors and ligands of the tumor necrosis factor superfamily (TNFSF) provide costimulatory signals that control the survival, proliferation, differentiation, and effector function of immune cells. All components of the TNF superfamily are associated with NF-kB functions that are not limited to cell death and may promote survival in the face of adipose tissue inflammation in obesity. Inflammation and pro-inflammatory dysfunction of mitochondria are key factors associated with insulin resistance in obesity. The aim of the study was to analyze the relationship of soluble forms of receptors and ligands of the TNF superfam-ily in blood plasma with mitochondrial dynamics in adipose tissue (greater omentum (GO) and subcutaneous adipose tissue (Sat)) of obese patients with and without type 2 diabetes mellitus (T2DM). Increased plasma sTNF-R1, sTNF-R2, sTNFRSF8 receptors and ligands TNFSF12, TNFSF13, TNFSF13B are characteristic of obese patients without T2DM. Increases in TNFSF12, TNFSF13B, and sTNF-R1 levels are associated with decreased glucose concentration and decreased BMI in obese patients. The gene expression levels responsible for regulating mitochondrial dynamics were increased in obese patients without T2DM and were unbalanced in patients with obesity and T2DM.

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“…A decrease in HDL and an increase in LDL are associated with obesity. Plasma levels of sTNF-R1, TNFSF12, TNFSF13, and TNFSF13B correlated positively with HDL levels and negatively with LDL levels [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Receptor Superfamily Interact with Fusion and Fission of Mitochondria of Adipose Tissue in Obese Patients without Type 2 Diabetes

et al. 2021

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Interactions between receptors and ligands of the tumor necrosis factor superfamily (TNFSF) provide costimulatory signals that control the survival, proliferation, differentiation, and effector function of immune cells. All components of the TNF superfamily are associated with NF-kB functions that are not limited to cell death and may promote survival in the face of adipose tissue inflammation in obesity. Inflammation dysfunction of mitochondria is a key factor associated with insulin resistance in obesity. The aim of the study was to analyze the relationship of soluble forms of receptors and ligands of the TNF superfamily in blood plasma with mitochondrial dynamics in adipose tissue (greater omentum (GO) and subcutaneous adipose tissue (Sat)) of obese patients with and without type 2 diabetes mellitus (T2DM). Increased plasma sTNF-R1, sTNF-R2, sTNFRSF8 receptors, and ligands TNFSF12, TNFSF13, TNFSF13B are characteristic of obese patients without T2DM. The TNF-a levels in blood plasma were associated with a decrease in MFN2 gene expression in GO and IL-10 in blood plasma. The TNFSF12 levels contributed to a decrease in glucose levels, a decrease in BMI, and an increase in IL-10 levels by influencing the MFN2 gene expression in GO, which supports mitochondrial fusion.

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Association of Decreased High-Density Lipoprotein Cholesterol (HDL-C) With Obesity and Risk Estimates for Decreased HDL-C Attributable to Obesity

Abstract: Decreased HDL-C is strongly associated with and largely attributable to obesity.

Cited by 21 publications

References 19 publications

Visceral Fat is Better Related To Liver Function and Lipid Metabolism Than Body Mass Index and Waist Circumference: A Cross-Sectional Study

Visceral Fat is Better Related To Liver Function and Lipid Metabolism Than Body Mass Index and Waist Circumference: A Cross-Sectional Study

Tumour Necrosis Receptor Superfamily Interact with the Mitochondrial Dynamics in Adipose Tissue in Obese Patients without Type 2 Diabetes

Tumor Necrosis Receptor Superfamily Interact with Fusion and Fission of Mitochondria of Adipose Tissue in Obese Patients without Type 2 Diabetes

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