Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians

Mittal, RD; Srivastava, Priyanka; Mittal, Tulika; Verma, Arti; Jaiswal, Praveen Kumar; Singh, Virinder; Mandal, Raju K.; Mandhani, Anil

doi:10.1016/j.ejso.2011.05.013

Cited by 24 publications

(25 citation statements)

References 20 publications

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“…Considered separately for pooling subgroup analysis. The distribution of genotypes in the controls of all the studies was in agreement with Hardy-Weinberg equilibrium, except two studies (Frank et al, 2005;Mittal et al, 2011).…”

Section: Eligible Studiessupporting

confidence: 67%

Association of DR4 (TRAIL-R1) Polymorphisms with Cancer Risk in Caucasians: an Updated Meta-analysis

Chen

Tang²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Eligible Studiessupporting

confidence: 67%

Association of DR4 (TRAIL-R1) Polymorphisms with Cancer Risk in Caucasians: an Updated Meta-analysis

Chen

Tang²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In a recent study, a significant risk was observed in the rs3181320*C carrier of the CASP-5 gene. In CASP-5 rs507879 T>C, C allele carriers were at a higher risk of breast cancer (14). By contrast, Ulybina et al (15) did not find any significant association with CASP-5 (15).…”

Section: Discussionmentioning

confidence: 75%

“…Four studies (14,15,21,22) were included and 101 articles were excluded in the present meta-analysis. The flow chart of study selection is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Investigations into the association between CASP-1, -2 and -5 and cancer risk are ongoing. Mittal et al (14) and Dong et al (13) have found that C allele carriers of rs507879 in CASP-5 were at higher risk of cancer. However, a contradictory result was found in another study where no significant association was identified between CASP-5 and cancer risk (15).…”

Section: Introductionmentioning

confidence: 99%

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CASP-1, -2 and -5 gene polymorphisms and cancer risk: A review and meta-analysis

et al. 2013

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Abstract. Accumulating evidence suggests the CASP gene family is important in the development of carcinogenesis. These genetic polymorphisms have been extensively investigated as a potential risk factor for cancer, but results have been inconclusive. This Human Genome Epidemiology (HuGE) review and meta-analysis was performed to investigate the associations between CASP-1, -2 and -5 and cancer risk. A literature search of Pubmed, Embase, Web of Science and CBM databases was conducted from inception through September 1st, 2012. Four case-control studies with a total of 1,592 cancer cases and 1,833 healthy controls were included in the present meta-analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Five polymorphisms were examined, including rs501192 (G>A), rs4647297 (C>G), rs507879 (T>C), rs3181320 (G>C) and rs523104 (G>C). Meta-analysis results showed that the rs3181320*C allele/carrier were associated with increased risk of various types of cancers (OR=1.26; 95% CI, 1.04-1.54; P=0.020 and OR=1.33; 95% CI, 1.00-1.75; P=0.047, respectively). However, similar associations were not found in the rs501192, rs4647297, rs507879 and rs523104 polymorphisms (all P>0.05). Results from the current meta-analysis suggest that the rs3181320*C allele/carrier in CASP-5 gene are potential risk factors for cancer.

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“…Caspases (CASP), with 14 known members, comprise a family characterized by highly conserved intracellular aspartate-specific cysteine proteases (Van De Water et al, 2004;Mittal et al, 2011). Two types are recognized in the CASP family: initiator caspases and effector caspases.…”

Section: Introductionmentioning

confidence: 99%

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer

Zhang¹,

Yang²,

Jin³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. In this Human Genome Epidemiology review and meta-analysis, we summarized the available evidence associating lung cancer with the CASP gene family. Seven studies, which included 1155 lung cancer cases and 1120 healthy controls, met the inclusion criteria and were included in our meta-analysis. In seven studies, 19 different SNPs have been studied in seven CASP genes, including CASP-1, -2, -5, -7, -8, -9, and -10. Meta-analysis results showed positive associations between heterozygote (A/G) of rs507879 in the CASP-5 gene, the T allele of rs12415607 in the CASP-7 gene, and the T allele and T carrier (C/T+T/T) of rs4645981 in the CASP-9 gene with lung cancer susceptibility [odds ratio (OR) = 1.83, 95% confidence interval (95%CI) = 1.07-3.12, P = 0.03; OR = 1.18, 95%CI = 1.02-1.37, P = 0.03; OR = 1.43, 95%CI = 1.12-1.81, P = 0.004; OR = 1.46, 95%CI = 1.10-1.93, P = 0.009; respectively]. However, we found that homozygote (G/G) of rs2227310 in the CASP-7 gene, del allele, heterozygote (ins/del), and del carrier (ins/del + del/del) of rs3834129 in CASP-8 could be protective factors for lung cancer (OR = 0.17, 95%CI = 0.14-0.21, P = 0.0003; OR = 0.83, 95%CI = 0.72-0.97, P = 0.02; OR = 0.74, 95%CI = 0.64-0.85, P < 0.0001; OR = 0.81, 95%CI = 0.71-0.93, P = 0.002; respectively). In conclusion, based on this meta-analysis, we suggest that SNPs in CASP-5, -7, -8, and -9 are associated with susceptibility to lung cancer.©FUNPEC

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Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians

Cited by 24 publications

References 20 publications

Association of DR4 (TRAIL-R1) Polymorphisms with Cancer Risk in Caucasians: an Updated Meta-analysis

Association of DR4 (TRAIL-R1) Polymorphisms with Cancer Risk in Caucasians: an Updated Meta-analysis

CASP-1, -2 and -5 gene polymorphisms and cancer risk: A review and meta-analysis

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer

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