Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis

Abstract

ABSTRACT. Endometriosis is a disease that affects 10 to 15% of the women of reproductive age. It is characterized by the presence of endometrial-like tissues outside of the uterus. Some definitions claim that the functional ectopic tissue is sensitive to the action of hormones. Severity of endometriosis is defined according to a system proposed by the American Society for Reproductive Medicine, which is based on laparoscopic findings. A large number of genetic polymorphisms has been reported for CYP1A1, the gene that is responsible for enzymes involved in stage I detoxification of xenobiotics; this gene is located at 15q22-24, and encodes an isoenzyme that catalyzes the oxidation of polycyclic aromatic hydrocarbons present in phenolic compounds and epoxides. The aim of this study was to analyze the frequency of the MspI polymorphism and its relation to endometriosis. We obtained peripheral blood samples from 52 women with endometriosis (confirmed by laparoscopy) as well as 42 women without endometriosis (control group). In the case group, the women were between 25 and 35 years of age; the age range was between 25 and 57 years old in the control group. Molecular analysis was performed by polymerase chain reaction. We found a significant association (P = 0.039) between the polymorphic allele m1 and endometriosis (32.70%). In conclusion, this study showed that the m1 polymorphism is associated with endometriosis, and that W1/m1 and m1/m1 polymorphisms are more frequently observed in patients with infertility and severe endometriosis.

Sex hormone-related polymorphisms in endometriosis and migraine: A narrative review

“…The case-control study with the smaller sample size investigated the T > C change. 115 Four Asian studies also investigated this base pair change, but found no association. 72,105,[116][117][118][119] No association with migraine was found.…”

Dna Barcoding Confirma a Ocorrência De Espécies Amazônicas Na Ictiofauna Do Rio Turiaçu, Maranhão/Brasil

“…A mutação de genes também está associada à infertilidade na endometriose. Alguns dos principais genes polimórficos que podem aumentar o risco de desenvolvimento de endometriose compreendem a interleucinas (MATALLIOTAKIS et al, 2018;ZHAO et al, 2018), arilamina N-acetiltransferase 2 (NAT2) (FAYEZ et al, 2018), CYP1A1 (BARBOSA et al, 2016;MOURA, 2016b), p53 (DE MORAIS et al, 2016, p. 53;SANTOS et al, 2018;MOURA, 2016b) e eNOS (SANTOS et al, 2018). A figura 5 mostra a interação de duas proteínas importantes, cujas expressões podem estar alteradas em pacientes com endometriose.…”

Molecular genetics of male infertility: A mini-review

“…CYP1A1 regulates phase I metabolism of polycyclic aromatic hydrocarbons that can be harmful to the homeostasis of mammal's reproductive system [32]. A large variety of studies have investigated the relationship between CYP1A1 polymorphisms and infertility in Chinese [33][34][35], Brazilian [36], Indian [37], Turkish [38] and German [40] populations. Another risk factor for male infertility is the polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene.…”