Association of CYP19 Gene Polymorphism with Vertebral Fractures in Japanese Postmenopausal Women

Koudu, Yasuko; Onouchi, Tsuneko; Hosoi, Takayuki; Horiuchi, Toshiyuki

doi:10.1007/s10528-011-9483-z

Cited by 7 publications

(4 citation statements)

References 22 publications

(22 reference statements)

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“…27,35 Importantly, the rs2470152 locus itself is a potential binding site for a transcription protein cyclic adenosine monophosphate response element (CRE). 36,37 In our study, T-risk-allele carriers had lower CSF E2/T ratios and worse GOS-6 scores. Importantly, the T allele was linked with higher testosterone in both serum and CSF.…”

Section: Garringer Et Alsupporting

confidence: 50%

Impact of Aromatase Genetic Variation on Hormone Levels and Global Outcome after Severe TBI

Garringer

Niyonkuru

McCullough

et al. 2013

Journal of Neurotrauma

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Although experimental traumatic brain injury (TBI) studies support estradiol as a neuroprotectant and potent stimulator of neuroplasticity, clinical studies suggest a negative association between endogenous estradiol profiles and mortality/poor outcomes. However, no studies have evaluated associations with cerebral spinal fluid (CSF) hormone profiles and aromatase gene (cytochrome P450 [CYP]19A1) variability on clinical TBI outcomes. We evaluated 110 adults with severe TBI. Average and daily estradiol, testosterone, and estradiol/testosterone ratios (E2:T) were measured using CSF and serum samples and compared to healthy controls. Eighteen tagging and four functional single-nucleotide polymorphisms (SNPs) for CYP19A1 were genotyped and compared to hormones, acute mortality, and Glasgow Outcome Scale (GOS) scores 6 months post-TBI. TBI subjects had lower CSF estradiol over time versus controls. CSF testosterone was initially high, but declined over time. E2/T ratios were initially low, compared to controls, but rose over time. Higher mean E2/T ratio in bivariate analysis was associated with lower mortality ( p = 0.019) and better GOS-6 scores ( p = 0.030). rs2470152 influenced CSF E2/T ratio and also serum and CSF testosterone ( p £ 0.05 all comparisons). Multiple-risk SNPs rs2470152, rs4646, and rs2470144 were associated with worse GOS-6 scores ( p £ 0.05, all comparisons), and those with > 1 risk SNP variant had a higher risk for poor outcome, compared with those with £ 1 risk variant. TBI results in low CSF estradiol and dynamic CSF testosterone and E2/T ratio. In contrast to clinical serum hormone studies, higher CSF E2/T ratio was associated with better outcome. Further, genetic variation in CYP19A1 influences both hormone dynamics and outcome post-TBI.

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Section: Garringer Et Alsupporting

confidence: 50%

Impact of Aromatase Genetic Variation on Hormone Levels and Global Outcome after Severe TBI

Garringer

Niyonkuru

McCullough

et al. 2013

Journal of Neurotrauma

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“…Some well-known polymorphisms that are recently studied outside India are CYP19 gene, ESR2 AluI gene, DBP gene and osteoprotegerin (OPG) gene. [ 8 9 10 11 ]…”

Section: Discussionmentioning

confidence: 99%

Overview of research studies on osteoporosis in menopausal women since the last decade

Thulkar¹,

Singh²

2015

J Mid-life Health

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Purpose/Introduction:Osteoporosis is a multifactorial and slowly emerging global health problem. The lifetime risk of dying from hip fracture is same as that from breast cancer. One out of three women between age group of 50-60 years in India suffers from osteoporosis. Indian women have an early age of onset of osteoporosis as compared to western counterparts. There is need for early diagnosis, identification of high-risk groups and prevention and treatment of osteoporosis in the Indian context. The aim of this study was to review the literature published in last decade and compare the research in India with that in rest of the world.Materials and Methods:Research articles with key words menopausal, osteoporosis and bone mineral density were searched in Pubmed from January 2004 to December 2013. Articles were categorized according to year, place and objective of the studies.Results:In India more articles were published in year 2010-11 (53.3%), while outside the country a uniform distribution of studies was observed throughout the last decade. Objective of research was screening and diagnosis (36.7%) and risk factor identification (40%) in most of the Indian studies as compared to rest of the world. Research publications on prevention and treatment of osteoporosis are less in India (20%).Conclusion:Research focusing on diagnosis, prognosis, prevention and treatment are needed in India.

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“…Aromatase is encoded by the CYP19 gene, and genetic variations in the CYP19 gene result in alterations of circulating levels of sex hormones [ 91 – 93 ]. Ma et al suggests that genetic variations in CYP19 might contribute to variations in the pathophysiology of E2-dependent diseases [ 94 ].…”

Section: Aromatase and The Cardiovascular Systemmentioning

confidence: 99%

The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

et al. 2017

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Epidemiologic studies have previously suggested that premenopausal females have reduced incidence of cardiovascular disease (CVD) when compared to age-matched males, and the incidence and severity of CVD increases postmenopause. The lower incidence of cardiovascular disease in women during reproductive age is attributed at least in part to estrogen (E2). E2 binds to the traditional E2 receptors (ERs), estrogen receptor alpha (ERα), and estrogen receptor beta (ERβ), as well as the more recently identified G-protein-coupled ER (GPR30), and can exert both genomic and non-genomic actions. This review summarizes the protective role of E2 and its receptors in the cardiovascular system and discusses its underlying mechanisms with an emphasis on oxidative stress, fibrosis, angiogenesis, and vascular function. This review also presents the sexual dimorphic role of ERs in modulating E2 action in cardiovascular disease. The controversies surrounding the clinical use of exogenous E2 as a therapeutic agent for cardiovascular disease in women due to the possible risks of thrombotic events, cancers, and arrhythmia are also discussed. Endogenous local E2 biosynthesis from the conversion of testosterone to E2 via aromatase enzyme offers a novel therapeutic paradigm. Targeting specific ERs in the cardiovascular system may result in novel and possibly safer therapeutic options for cardiovascular protection.

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Association of CYP19 Gene Polymorphism with Vertebral Fractures in Japanese Postmenopausal Women

Cited by 7 publications

References 22 publications

Impact of Aromatase Genetic Variation on Hormone Levels and Global Outcome after Severe TBI

Impact of Aromatase Genetic Variation on Hormone Levels and Global Outcome after Severe TBI

Overview of research studies on osteoporosis in menopausal women since the last decade

The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

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