Association of cyclic peptides in aqueous solution measured by fluorescence quenching

Karlström, Amelie; Undén, Anders

doi:10.1002/(sici)1097-0282(199701)41:1<1::aid-bip1>3.3.co;2-s

Cited by 7 publications

(8 citation statements)

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“…Their results suggest detectable association even in the strongly competing aqueous medium. [51] Tubular ensembles from cyclic b-peptides: Seebach and coworkers have reported that cyclic tetrapeptides composed of chiral b 3 -amino acids can adopt similar disklike conformations and stack to form hollow tubular structures. [46] Analyses of X-ray powder diffraction and molecular modeling of…”

Section: Discussionmentioning

confidence: 99%

Peptide Nanotubes and Beyond

1998

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Section: Discussionmentioning

confidence: 99%

Peptide Nanotubes and Beyond

1998

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“…Their data indicate detectable intersubunit hydrogen bonding even in the strongly competing aqueous medium. [89] 4.1.2. Self-Assembling Transmembrane Ion Channels and Pore Structures from Cyclic d,l-a-Peptides A noteworthy feature of cyclic d,l-peptide nanotubes is the ease with which the external surface properties and internal diameter of the tubular ensemble may be altered through appropriate choice of amino acid side chains and the size of the peptide ring, respectively.…”

Section: Helical Folding Of Linear Oligophenylacetylenesmentioning

confidence: 99%

Self-Assembling Organic Nanotubes

Bong

Clark

Granja

et al. 2001

Angew. Chem. Int. Ed.

1,076

130

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“…Die geringe Löslichkeit der cyclischen D , L ‐Peptid‐Untereinheiten und die hohe Stabilität der sich bildenden Aggregate legen eine bedeutende Präorganisation der monomeren Einheiten und einen stark kooperativen Aggregationsprozess nahe. Bei der Untersuchung der Assoziation cyclischer D , L ‐Octapeptide in Wasser mit einem Fluoreszenzlöschungs‐Assay stellten Karlström und Udén fest, dass sich H‐Brücken zwischen den Untereinheiten selbst im wässrigen Medium bilden, das ebenfalls starke H‐Brücken zu den Untereinheiten zu bilden vermag 89…”

Section: Stapelung Von Ringenunclassified

Sequestration of connexin43 in the early endosomes: An early event of Leydig cell tumor progression

Segretain

Decrouy

Dompierre

et al. 2003

Molecular Carcinogenesis

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Connexins form gap junction channels that allow intercellular communication between neighboring cells. Compelling evidence has revealed that Cx are tumor-suppressor genes and reduced Cx expression has been related with uncontrolled cell growth in tumors and transformed cells. In the present study, we addressed Cx transcriptional and posttranscriptional regulations during the earlier stage of testicular tumors confined to Leydig cells in a transgenic mice model. In situ hybridization indicated that connexin43 (Cx43) mRNA was highly expressed either at early tumorogenesis (3 m) characterized by intense proliferation of Leydig cells, or at advanced tumorogenesis (6-7 m) when tumor cells completely invaded the testis. In contrast, Cx43 protein analyzed by Western blotting or classic immunohistochemical analyses was present at the beginning of tumor progression, but was dramatically reduced as tumor advanced. Application of high-resolution deconvolution microscopy to testis sections demonstrates that cells that proliferate exhibited an aberrant cytoplasmic Cx43 localization, in contrast to the expected plasma membrane Cx43 localization in normal Leydig cells. Dual immunofluorescence labeling with specific markers of cellular compartments shows that cytoplasmic Cx43 signal was mainly sequestered within early endosomes. Altogether, this study provides the first evidence that impaired Cx43 trafficking in endosomes is an early event associated with uncontrolled cell proliferation that could serve as a neoplastic marker.

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Association of cyclic peptides in aqueous solution measured by fluorescence quenching

Cited by 7 publications

References 0 publications

Peptide Nanotubes and Beyond

Peptide Nanotubes and Beyond

Self-Assembling Organic Nanotubes

Sequestration of connexin43 in the early endosomes: An early event of Leydig cell tumor progression

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