Association of CTLA-4 gene polymorphisms and alopecia areata: a systematic review and meta-analysis

Zhou, Boyang; Chen, Mojun; Shang, Shuai; Zhao, Jian

doi:10.1080/1354750x.2022.2046855

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…One of the association studies has suggested that CTLA-4 may be an important risk factor for AA in the European population and is also in connection with the severity of the disease (Salinas-Santander et al, 2020). In another meta-analysis study (2858 AA patients and 5444 healthy control), a meaning relationship was found between CTLA-4 rs231726 polymorphism and AA, but no relationship was ascertained between rs231775 and rs3087243 polymorphisms and AA (Zhou et al, 2022).…”

Section: Discussionmentioning

confidence: 98%

Analysis of Ctla 4 Gene +49a/G and Ct60 a/G Polymorphisms in Alopecia Areata Patients

BOZKURT,

ŞAHİN,

SEZER SONDAŞ

et al. 2023

Sabuncuoglu Serefeddin Health Sciences

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Abstract Alopecia areata (AA) is a common, has organ-specific semptoms and an autoimmune disease that targets hair follicles and causes scarring, hair or hair loss. Although the etiopathogenesis of AA has not been clarified yet; In addition to attitude, psychological factors and persistence factors, autoimmune and inflammatory cells have a polygenic character in which genes are effective. Immunological hair follicle dysfunction process in AA are controlled by activated T cells. It is thought that cytokines released in T cells may cause hair loss in AA. Studies have reported that various genes of the immune system, such as interleukin and cytotoxic T lymphocyte-associated antigen 4 (CTLA4), are effective in the development of the cell membrane, and dysfunction of the CTLA-4 antigen may be associated with various diseases. The CTLA-4 gene polymorphism is thought to be associated with impaired control of T cell proliferation, and this gene is thought to be a candidate gene for susceptibility to autoimmunity. This study was conducted to investigate whether CTLA4 CT60 A/G and +49AG polymorphisms have a role in susceptibility to Alopecia Areata. 195 patients and 173 healthy volunteer controls were included in the study, and genotype and allele frequencies were determined by PCR-RFLP method. The obtained data were analyzed with OpenEpi. Our results showed that the +49AG polymorphism was not associated with AA susceptibility in the Turkish population, but the CT60 polymorphism might be associated with AA susceptibility. However, more studies are needed to confirm our results. Key Words: Alopecia areata, CTLA4, Immunity, PCR-RFLP Özet Alopesi areata (AA), saç foliküllerini hedef alan ve yara izi, saç veya saç dökülmesine neden olan yaygın, otoimmün bir hastalıktır. AA'nın etyopatogenezi henüz netlik kazanmamış olmakla birlikte; Tutum, psikolojik faktörler ve kalıcılık faktörlerine ek olarak, otoimmün ve enflamatuar hücreler, genlerin etkili olduğu poligenik bir karaktere sahiptir. AA'daki kıl folikülü disfonksiyon mekanizmaları immünolojiktir ve aktifleştirilmiş T hücreleri tarafından kontrol edilir. T hücrelerinde salınan sitokinlerin AA'da saç dökülmesine neden olabileceği düşünülmektedir. Çalışmalar, interlökin ve sitotoksik T lenfosit ilişkili antijen 4 (CTLA4) gibi bağışıklık sisteminin çeşitli genlerinin hücre zarının gelişiminde etkili olduğunu ve CTLA-4 antijeninin işlev bozukluğunun çeşitli hastalıklarla ilişkili olabileceğini bildirmiştir. . CTLA-4 gen polimorfizminin, T hücre proliferasyonunun bozulmuş kontrolü ile ilişkili olduğu ve bu genin otoimmüniteye yatkınlık için aday bir gen olduğu düşünülmektedir. Bu çalışma, CTLA4 +49AG ve CT60 polimorfizmlerinin Alopesi Areata'ya duyarlılıkta rolü olup olmadığını araştırmak amacıyla yapılmıştır. 195 hasta ve 173 sağlıklı kontrol çalışmaya dahil edildi ve genotip ve alel frekansları PCR-RFLP yöntemi ile belirlendi. Elde edilen veriler OpenEpi ile analiz edilmiştir. Sonuçlarımız, Türk popülasyonunda +49AG polimorfizminin AA duyarlılığı ile ilişkili olmadığını, ancak CT60 polimorfizminin AA duyarlılığı ile ilişkili olabileceğini göstermiştir. Ancak, sonuçlarımızı doğrulamak için daha fazla çalışmaya ihtiyaç vardır. Anahtar Kelimeler: Alopesi areata, CTLA4, Bağışıklık, PCR-RFLP

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Section: Discussionmentioning

confidence: 98%

Analysis of Ctla 4 Gene +49a/G and Ct60 a/G Polymorphisms in Alopecia Areata Patients

BOZKURT,

ŞAHİN,

SEZER SONDAŞ

et al. 2023

Sabuncuoglu Serefeddin Health Sciences

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“…If five studies or more were included in a comparison, funnel plots were performed to estimate the publication bias. For all comparisons, a value of p < 0.05 was defined as statistical significance ( 17 ).…”

Section: Methodsmentioning

confidence: 99%

Association between retinol binding protein-4 and psoriasis vulgaris: a systematic review and meta-analysis

Gao,

Cui,

Cheng

2023

Front. Med.

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BackgroundPsoriasis vulgaris is a chronic skin disease which is related to cardiovascular and metabolic diseases. In the pathogenesis of these diseases, adipokines, including retinol binding protein-4 (RBP-4), play crucial roles. Studies have also shown that RBP-4 might be a meaningful factor in psoriasis however, relying on the analysis of a single study have some drawbacks.ObjectiveTo evaluate the association between RBP-4 and psoriasis vulgaris more comprehensively.MethodsSix databases were searched to obtain relevant publications. The selection of the included studies was based on a criteria. The standardized mean difference (SMD) was used for analysis. A value of p < 0.05 was defined as significance.ResultsSeven studies were included, with 271 cases and 235 controls. In the comparison between patients and controls, the merged data suggested that levels of RBP-4 were significantly higher in patients (SMD = 0.61, 95%CI: 0.14, 1.07, p < 0.05). In five studies containing the data of RBP-4 levels before and after treatment, no significance was found, either for RBP-4 levels in the after-treatment group and control group in these five studies (p > 0.05). Subgroup analysis was conducted based on the therapy method. Patients with systematic treatment showed a significant decrease of BRP-4 level after the treatment (SMD = −0.64, 95%CI: −1.26, −0.03, p < 0.05).ConclusionFor patients with psoriasis vulgaris, RBP-4 levels are elevated, and systematic treatment can lower these levels. RBP-4 might act as a key indicator for the diagnosis, efficacy assessment, and comorbidity monitoring of the patients. Further studies with well-designed protocols and enlarged populations are still needed.

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“…The increase in these markers suggest an inflammatory milieu, implicating these factors in the autoimmune attack on hair follicles. A significant correlation between the CTLA-4 rs231726 polymorphism and AA susceptibility has also been found [30], which is indicative of mutations in the development of peripheral tolerance and autoimmunity, as well as a significant correlation between the PTPN22 rs2476601 polymorphism (the most common single-nucleotide polymorphism of the gene) and AA [31]. Such genetic markers can help identify inheritance and at-risk populations, along with the development of targeted therapies, for earlier treatment of hair loss.…”

Section: Alopecia Areatamentioning

confidence: 97%

Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies

Tan,

Podwojniak,

Parikh

et al. 2024

CIMB

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The evolution of personalized medicine in dermatology signifies a transformative shift towards individualized treatments, driven by the integration of biomarkers. These molecular indicators serve beyond diagnostics, offering insights into disease staging, prognosis, and therapeutic monitoring. Specific criteria guide biomarker selection, ensuring attributes like specificity, sensitivity, cost feasibility, stability, rapid detection, and reproducibility. This literature review, based on data from PubMed, SCOPUS, and Web of Science, explores biomarkers in Hidradenitis Suppurativa (HS), Psoriasis, Atopic Dermatitis (AD), Alopecia Areata (AA), Vitiligo, and Chronic Spontaneous Urticaria (CSU). In HS, TNF-α, IL-1β, and MMPs serve as biomarkers, influencing targeted therapies like adalimumab and anakinra. Psoriasis involves biomarkers such as TNF-α, IL-23, and HLA genes, shaping treatments like IL23 and IL17 inhibitors. AD biomarkers include ECP, IL-4, IL-13, guiding therapies like dupilumab and tralokinumab. For AA, lipocalin-2, cytokines, and genetic polymorphisms inform JAK inhibitors’ use. Vitiligo biomarkers range from cytokines to genetic markers like TYR, TYRP1, guiding treatments like JAK inhibitors. CSU biomarkers encompass IgE, cytokines, and autologous serum tests, influencing therapies like omalizumab and cyclosporine. Comparing conditions, common proinflammatory markers reveal limited specificity. While some biomarkers aid diagnosis and standard treatments, others hold more scientific than clinical value. Precision medicine, driven by biomarkers, has shown success in skin malignancies. Future directions involve AI-powered algorithms, nanotechnology, and multi-omics integration for personalized dermatological care.

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Association of CTLA-4 gene polymorphisms and alopecia areata: a systematic review and meta-analysis

Cited by 6 publications

References 39 publications

Analysis of Ctla 4 Gene +49a/G and Ct60 a/G Polymorphisms in Alopecia Areata Patients

Analysis of Ctla 4 Gene +49a/G and Ct60 a/G Polymorphisms in Alopecia Areata Patients

Association between retinol binding protein-4 and psoriasis vulgaris: a systematic review and meta-analysis

Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies

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