Association of CRP gene polymophism with CRP levels and coronary artery disease in type 2 diabetes in Ahwaz, Southwest of Iran

Abstract

Introduction: We evaluated the association between four polymorphisms in the CRP gene with serum C-reactive protein (CRP) levels, prevalence and severity of coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) patients. Methods: We performed coronary angiography for 308 T2DM patients and classified them into two groups: T2DM with CAD and T2DM without CAD. All patients were from Ahvaz, Iran. serum levels of CRP, glucose and lipid profile were measured. Genotyping was performed by PCR/RFLP, and the severity of coronary artery disease was determined by Gensini score. Results: The GG genotype of SNP rs279421 was associated with the increased risk of CAD (OR= 2.38; 95% CI: 1.12- 5.8; p= 0.02) and CA, TT, TA genotypes and A allele of SNP rs3091244 and GA genotypes and A allele of SNP rs3093062 were significantly associated with increased CRP levels. None of genotypes or alleles was associated with Gensini score. We found that the haplotype 7 (AGCG) was associated with decreased risk of CAD (OR= 0.11; 95% CI: 0.02, 0.66; p= 0.017) and the Gensini score was correlated with increased levels of CRP, only in CAD group. Conclusion: Although genetic polymorphisms were influenced on serum RP levels, none of the alleles and genotypes raising or falling C-reactive protein levels was consistently associated with an increased prevalence of CAD or protected from that.

Association of the CETP TaqIB Polymorphism with Coronary Artery Disease in Type 2 Diabetic Patients

“…A total of 150 participants without coronary arteries stenosis were selected as the control group and 142 ones with more than 50% blockage of one of the coronary arteries as the case group. Inclusion and exclusion criteria for the participants and the criteria for determining the stenosis of the coronary arteries have already been published in another article (33). After fasting for 12 hours, 5 ml blood sample was obtained in non-EDTA tubes from each person for plasma preparation and 2 ml was taken in EDTA tube for DNA extraction.…”

Combined Effects of Single Nucleotide Polymorphisms (SNPs) within C-reactive Protein (CRP) and Environmental Parameters on Risk and Prognosis for Diabetic Foot Osteomyelitis Patients

“…Based on genome-wide association studies (GWASs) relevant to CRP [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], the SNPs that could affect serum level of CRP were selected and included in this investigation. We also included SNPs with a confirmed association with inflammatory disorders [39][40][41][42][43]. Finally, rs11265260, rs1205, rs12093699, rs1800947, rs2794520, rs1341665, rs3093059, rs3093068, rs3122012, rs7553007, and rs1130864 were assessed in this study.…”

C‐reactive protein (CRP) rs3093059C predicts poor mizolastine response in chronic spontaneous urticaria patients with elevated serum CRP level

“…For instance, it has been reported that the coagulation system and complement system participate in the mast cell activation in CSU patients . C‐reactive protein (CRP), encoded by the CRP gene, is greatly increased during infection, acute injury and autoimmune‐related diseases . CRP is regarded as an acute phase protein (APP) in the course of mast cell degranulation and complement system activation in the coagulation system .…”

“…[15,16] C-reactive protein (CRP), encoded by the CRP gene, is greatly increased during infection, acute injury and autoimmune-related diseases. [17] CRP is regarded as an acute phase protein (APP) in the course of mast cell degranulation and complement system activation in the coagulation system. [18][19][20][21] CRP is correlated with the disease severity of CSU.…”