Association of COVID-19 Infection and Purpura Fulminans

Dashti, Anahita Sanaei; Dehghani, Seyed Sina; Moravej, Hossein; Abootalebi, Seyyedeh Narjes

doi:10.5812/pedinfect.109843

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…Some experts postulate endothelial injury and venous stasis as the contributing etiology to these VTE events in the settings of microvascular inflammation and acute systemic inflammatory response led by a cytokines storm such as interleukin (IL)-6 and other acute phase reactants [2]. There have been rare case reports of purpura fulminans associated with COVID-19 infection [3][4][5]. In this condition, protein C deficiency or severe acute sepsis is accountable for most of the cases, although an idiopathic etiology is also common.…”

Section: Introductionmentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia Presenting Concomitantly With Purpura Fulminans: A Case Report

Ciprian¹

2022

Cureus

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has been extensively described in its most common presentations. Its pathogenetic process is poorly understood, although it is theorized that endothelial damage and inflammation play a central role. Its prothrombotic nature affects multiple organs, including lungs, kidneys, and the central nervous system. Rarer are cutaneous presentations that can be triggered or displayed concomitantly with COVID-19. Purpura fulminans is a lifethreatening syndrome that results in skin thrombosis and hemorrhagic infarction. While its association is explicit in critically ill patients with sepsis, few or rare cases have been described to be linked with COVID-19. In this report, we present a case of a critically ill patient with COVID-19 who showed signs of purpura fulminans while in the intensive care unit.

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Section: Introductionmentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia Presenting Concomitantly With Purpura Fulminans: A Case Report

Ciprian¹

2022

Cureus

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Two Cases of COVID-19 Patients With Associated Purpura Fulminans

Pangburn

Gibbs

2022

Journal of Burn Care &Amp; Research

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Purpura fulminans (PF) is a life threatening emergency involving coagulopathy and widespread skin necrosis. Early treatment, especially surgical management, is imperative as prognosis can be very poor. PF is most commonly associated with severe bacterial illness; however, viral causes are also possible. Currently in the literature, there have only been a handful of PF cases associated with COVID-19. We present two cases of PF in the setting of COVID-19 infection. Both patients had a history of underlying coagulopathies. PF can be a sign of underlying coagulopathy in a COVID-19 patient, who is already at increased risk for thromboembolic events due to the inflammatory nature of COVID itself. Due to how quickly PF can develop into life threatening necrosis and multi organ failure, it is imperative that these patients are referred early to a burn center for more advanced care.

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A COVID-19 Patient Presenting with Pneumothorax

Abootalebi

Shorafa

Abbaspour

et al. 2021

Case Reports in Infectious Diseases

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that has affected millions of individuals across the world. It was officially declared as a pandemic on March 11, 2020. Although most patients with COVID-19 manifest as viral pneumonia characterized by symptoms such as fever, dyspnea, and cough, atypical presentations such as acute respiratory distress syndrome (ARDS) and acute kidney or cardiac injury have been reported amongst COVID-19 patients. Bilateral and peripheral ground-glass and opacities are the hallmarks of COVID-19 infection on imaging exams. Herein, we aim to describe a COVID-19 patient who presented with shortness of breath, neck pain, chest pain, and bilateral pneumothorax in his imaging exam.

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Association of COVID-19 Infection and Purpura Fulminans

Cited by 5 publications

References 14 publications

Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia Presenting Concomitantly With Purpura Fulminans: A Case Report

Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia Presenting Concomitantly With Purpura Fulminans: A Case Report

Two Cases of COVID-19 Patients With Associated Purpura Fulminans

A COVID-19 Patient Presenting with Pneumothorax

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