Association of cord blood ghrelin, leptin and insulin concentrations in term newborns with anthropometric parameters at birth

Warchoł, Magdalena; Wojciechowska, Małgorzata; Kupsz, Justyna; Sot-Szewczyk, Magdalena Helena; Michalak, Michał; Kołodziejski, Paweł; Pruszyńska‐Oszmałek, Ewa; Krauss, Hanna

doi:10.1515/jpem-2017-0285

Cited by 12 publications

(16 citation statements)

References 35 publications

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“…There have been only a few studies evaluating ghrelin concentrations in preterm infants, and studies in SGA preterm infants are limited [23,[27][28][29]. Our data revealed a negative association between cord blood ghrelin levels and birth weight and gestational age in preterm newborns.…”

Section: Discussionmentioning

confidence: 54%

“…The differences in cord blood concentrations between SGA and AGA infants, when exposed to hypertension, suggest a probable role of adipokines in fetal growth. There are reports of an association of adipokine levels and fetal growth in the literature [23,24]. Previous studies have shown that these hormones may have an effect on anthropometric growth parameters [23,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…There are reports of an association of adipokine levels and fetal growth in the literature [23,24]. Previous studies have shown that these hormones may have an effect on anthropometric growth parameters [23,25,26]. However, these studies did not compare infants exposed to maternal hypertension.…”

Section: Discussionmentioning

confidence: 99%

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Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels

et al. 2020

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Maternal hypertension may alter physiological parameters, dysregulating the release of hormones such as adipokines, thus influencing the fetal growth course. This study investigated whether hypertensive disorders of pregnancy alter cord blood adipokine levels and correlate these with anthropometric parameters in preterm infants. This is a prospective cohort study with pregnant women < 37-week gestation with and without hypertension and their offspring. Cord blood leptin, adiponectin, and ghrelin were analyzed by LUMINEX®. These adipokines were compared between the groups exposed or not to gestational hypertension using non-parametric statistical tests. The hypertensive pregnancies had significantly higher cord blood leptin (1.00 (IQR 0.67-1.20 ng/mL)) and adiponectin (18.52 (IQR 17.52-25.13 μg/mL)) levels than those without hypertension (0.07 (IQR 0.06-0.08 ng/mL) and 8.13 (IQR 6.50-8.68 μg/mL), respectively, p < 0.0001). The adipokine levels were higher in AGA and SGA infants in the exposed group for both moderate and late preterm. SGA had significantly higher ghrelin levels than the AGA infants. Ghrelin levels were negatively correlated with birth weight (r = − 0.613, p < 0.001), birth length (r = − 0.510, p < 0.001), head circumference (− 0.346, p < 0.002), and gestational age (r = − 0.612, p < 0.001).Conclusions: Our findings demonstrate an increase in adipokine levels in the cord blood of preterm newborn infants exposed to maternal hypertension. What is Known:• Clinical evidence suggests that concentration of the serum adipokines may be affected by risk of hypertension in both adults and pregnant women.• Maternal profile as hypertension alters intrauterine environment and could affect the function of fetal metabolism, impairing fetal growth.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels

et al. 2020

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“…When antibodies against ghrelin are administered to rats during pregnancy, the size and weight of the rat litter is reduced compared to controls 33 . Similarly, babies born SGA have lower levels of cord ghrelin than normal‐sized babies 34,35 . Our previous work reports reduced circulating ghrelin during VSG pregnancy 36 .…”

Section: Introductionmentioning

confidence: 89%

“…33 Similarly, babies born SGA have lower levels of cord ghrelin than normal-sized babies. 34,35 Our previous work reports reduced circulating ghrelin during VSG pregnancy. 36 The effect of low endogenous ghrelin on the offspring of VSG pregnancy has not been addressed.…”

Section: Introductionmentioning

confidence: 97%

Ghrelin signalling is dysregulated in male but not female offspring in a rat model of maternal vertical sleeve gastrectomy

Spann

Welch

Grayson

2020

J Neuroendocrinology

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Bariatric surgery is the most effective and durable means of treating obesity and its comorbidities. Women make up 80% of those receiving weight loss surgery and they experience improvements in fertility. Unfortunately, bariatric surgery in the context of pregnancy is associated with complications, including growth restriction and small‐for‐gestational age offspring (SGA). SGA offspring have a greater risk for obesity in adulthood, although the mechanism for this SGA‐induced obesity is unknown. In a rat model of vertical sleeve gastrectomy (VSG), we previously identified reductions during pregnancy in ghrelin, a stomach‐derived hormone that increases appetite and induces growth hormone secretion. Here, we hypothesise that VSG offspring will have altered ghrelin signalling compared to offspring of Sham dams as a result of reduced in utero ghrelin. At postnatal day (PND)21, male and female offspring of dams that have previously received VSG have an increase in mRNA expression for the ghrelin receptor in the hypothalamus compared to Sham offspring, and the expression of GOAT is lower in females compared to males. Liver expression of endogenous ghrelin antagonist, LEAP2, is elevated at PND60 in VSG offspring. Expression of other genes in the growth hormone system (growth hormone‐releasing hormone and growth hormone) were not altered. Plasma levels of total ghrelin at PND21 are also not different between VSG and Sham pups. In adult pups, 1‐hour chow intake of male but not female VSG offspring given is less than Sham offspring when given 50 µg kg‐1 of exogenous ghrelin by i.p. injection. These results indicate that maternal VSG surgery has an impact on ghrelin signalling in offspring and that, as adults, male VSG offspring may be functionally less responsive to ghrelin than controls.

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Curbing Obesity from One Generation to Another: the Effects of Bariatric Surgery on the In Utero Environment and Beyond

Spann

Grayson

2020

Reprod. Sci.

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Approximately 250,000 individuals seek bariatric surgery each year in the U.S. for the long-term resolution of obesity-related comorbidities. Greater than 80% of these individuals are women and approximately half are of child-bearing age. Although there are many positive metabolic benefits that are realized through surgical weight loss for both men and women, the various long-term hormonal, molecular, nutrient and epigenetic changes following bariatric surgery have not been evaluated for the surgical recipient or in the context of pregnancy and the offspring. Pregnancy may be a vulnerable period of time for the bariatric surgery recipient and thoughtful consideration of pregnancy management should be taken by health care providers and recipients alike. The purpose of this review is to explore potential etiologies of some of the gestation-specific outcomes for the mother and offspring.

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Association of cord blood ghrelin, leptin and insulin concentrations in term newborns with anthropometric parameters at birth

Cited by 12 publications

References 35 publications

Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels

Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels

Ghrelin signalling is dysregulated in male but not female offspring in a rat model of maternal vertical sleeve gastrectomy

Curbing Obesity from One Generation to Another: the Effects of Bariatric Surgery on the In Utero Environment and Beyond

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