Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala

Butler-Dawson, Jaime; Dally, Miranda; Johnson, Richard J.; Johnson, Evan C.; Krisher, Lyndsay; Sánchez-Lozada, Laura G.; Griffin, Benjamin R.; Brindley, Stephen; Newman, Lee S.

doi:10.1159/000506619

Cited by 11 publications

(9 citation statements)

References 26 publications

(31 reference statements)

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“…In humans, copeptin (the stable vasopressin analogue) concentrations in plasma have been found to be significantly associated with increased risk of type two diabetes, chronic kidney disease, and cardiovascular disease [ 66 , 67 , 68 , 69 ]. Moreover, low water intake, which induces chronic vasopressin secretion [ 70 ], predicts the development of risk factors for coronary artery disease, for example, hyperglycemia [ 71 ].…”

Section: Metabolic Cardiovascular and Renal Effects Resulting From Po...mentioning

confidence: 99%

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases

et al. 2022

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Improper hydration habits are commonly disregarded as a risk factor for the development of chronic diseases. Consuming an intake of water below recommendations (underhydration) in addition to the substitution of sugar-sweetened beverages (SSB) for water are habits deeply ingrained in several countries. This behavior is due to voluntary and involuntary dehydration; and because young children are exposed to SSB, the preference for a sweet taste is profoundly implanted in the brain. Underhydration and SSB intake lead to mild hyperosmolarity, which stimulates biologic processes, such as the stimulation of vasopressin and the polyol-fructose pathway, which restore osmolarity to normal but at the expense of the continued activation of these biological systems. Unfortunately, chronic activation of the vasopressin and polyol-fructose pathways has been shown to mediate many diseases, such as obesity, diabetes, metabolic syndrome, chronic kidney disease, and cardiovascular disease. It is therefore urgent that we encourage educational and promotional campaigns that promote the evaluation of personal hydration status, a greater intake of potable water, and a reduction or complete halting of the drinking of SSB.

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Section: Metabolic Cardiovascular and Renal Effects Resulting From Po...mentioning

confidence: 99%

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases

et al. 2022

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“…Butler-Dawson et al demonstrated that cross-shift incidence of acute kidney injury was associated with both dehydration and lower electrolyte supplementation [ 33 ]. In a related study, Sorensen et al observed serum hyperosmolarity was associated with these cross-shift declines in kidney function, Sorensen et al [ 34 ] an effect that may be regulated via a vasopressin-mediated pathway of renal injury [ 35 ]. Ideally, to show the long-term success of such interventions in preventing kidney disease, longitudinal screening data should be combined with well-implemented interventions and longitudinal follow up.…”

Section: Introductionmentioning

confidence: 99%

Workplace Screening Identifies Clinically Significant and Potentially Reversible Kidney Injury in Heat-Exposed Sugarcane Workers

Sorensen

Krisher

Butler-Dawson

et al. 2020

IJERPH

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An epidemic of chronic kidney disease of unknown origin (CKDu) has emerged in the past two decades in agricultural communities, characterized by progressive renal failure with a dearth of early clinical symptoms. The aim of this study is to improve understanding of the natural history of this disease and to evaluate the impact of an educational and behavioral intervention on the trajectories of renal decline among a cohort of Guatemalan sugarcane workers. We identified groups of workers based on their kidney function during a longitudinal parent study conducted among sugarcane workers during the 2016–2017 harvest season. At the study’s first time point in February 2017, workers who developed abnormal kidney function (AKF) (estimated glomerular filtration rate, eGFR, <60 mL/min per 1.73 m2) were placed in the AKF group, workers with reduced kidney function (RKF) (eGFR 60–89) were placed in the RKF group, and workers who maintained normal kidney function (NKF) (eGFR ≥ 90) were placed in the NKF group. As part of the study, a health promotion, behavioral and educational intervention centered on water, electrolytes, rest, and shade (WERS) was provided to all study participants. We then prospectively analyzed renal function at the three study time points in February, March, and April. Additional data collected from previous harvests allowed for retrospective analysis and we compared the rate of change in eGFR over the previous five years (2012 to 2016) for each identified group. Mixed effects linear regression with random intercepts for the workers was used to investigate the difference in rates of change for the three groups and to assess the impact of the intervention study on rate of change of kidney function during the study compared to each group’s prior trajectory, utilizing the retrospective data collected during the five years prior to the study intervention. Between 2012 and 2016, eGFR declined at a rate of 0.18 mL/min per 1.73 m2 per year for the NKF group (95% CI: −0.66, 0.29, p = 0.45), 2.02 per year for the RKF group (95% CI: 1.00, 3.03, p = 0.0001) and 7.52 per year for the AKF group (95% CI: 6.01, 9.04, p < 0.0001). All study groups stabilized or improved their trajectory of decline during the intervention. This study supports the need to institute WERS interventions and to include mid-harvest screening protocols and longitudinal tracking of kidney function among sugarcane workers at high risk of CKDu. Early detection of rapid kidney function decline combined with appropriate interventions hold promise for stopping or slowing progression of renal insufficiency among these workers.

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“…The development and analysis of kidney injury biomarkers have also been the subject of research in this cluster. [68,[84][85][86][87][88][89][90][91][92][93] Despite the accelerated development in heat-related kidney health research shown in this study, gaps still exist in the research "hotspot" topics noted in this study. Such gaps exist, particularly in developing countries in Africa, Asia, the Middle East, and South America, which are reflected in their low research contributions and collaboration rates.…”

Section: Discussionmentioning

confidence: 84%

The impact of heat on kidney health: A PRISMA-compliant bibliometric analysis

Al-Bouwarthan¹,

AlMulla²,

Yaseen³

2022

Medicine

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Background: Exposure to excessive heat can impact kidney health. Climate change is projected to aggravate this impact. An analysis of articles published between 1958 and 2021 was conducted to explore the progress of the research on this issue.Methods: This study included a bibliometric analysis wherein Web of Science was used to generate a list of all published articles related to the impact of heat on kidney health. Basic information about the articles, such as titles, authors' names, keywords, and citations, were recorded and analyzed.Results: A total of 226 published articles related to the impact of heat on kidney health were identified as of November 20, 2021. Most of these articles (93%) were published within the last decade. The United States was the most prominent country in terms of research productivity and collaboration. Researchers from the United States were well represented among the top 20 contributors of published articles on the study issue. The productivity of the top 20 authors varied between 6 and 32 articles each. A total of 25 common words used by the authors were identified. The most frequently used keywords were chronic kidney disease, heat stress, acute kidney injury, Mesoamerican nephropathy, and climate change. Keyword analysis revealed 3 distinct major research clusters in the existing scientific research on the impact of heat on kidney health: chronic kidney disease of unknown etiology, heat stress and renal physiology, and the effect of climate change on kidney health.Conclusions: Research on heat-related kidney injury has witnessed rapid development in recent decades, motivated by the emergence of chronic kidney disease of unknown etiology and climate change. Developing countries in hot regions must increase their productivity in this research area through international collaboration and partnerships.Abbreviations: AKI = acute kidney injury, CKD = chronic kidney disease, CKDu = chronic kidney disease of unknown etiology, DALYs = disability-adjusted life years, LCS = local citation score, NP = number of published articles, SCP = single-country publications, TC = total citations, WoS = Web of Science.

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Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala

Cited by 11 publications

References 26 publications

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases

Workplace Screening Identifies Clinically Significant and Potentially Reversible Kidney Injury in Heat-Exposed Sugarcane Workers

The impact of heat on kidney health: A PRISMA-compliant bibliometric analysis

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