Association of Controlling Nutritional Status Score With Adverse Outcomes in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis

Abstract

This systematic review and meta-analysis sought to examine the association between the controlling nutritional status (CONUT) score and adverse outcomes in patients with coronary artery disease (CAD). PubMed and Embase databases were searched for eligible studies from their inceptions to December 12, 2021 to identify studies investigating the association of the CONUT score with major adverse cardiovascular events (MACEs) and all-cause mortality in CAD patients. Twelve studies (36,198 CAD) patients satisfied the criteria. Comparison of the high with low CONUT score, the pooled multivariate adjusted risk ratios (RR) was 1.78 (95% confidence intervals [CI] 1.36-2.32) for MACEs and 1.45 (95% CI 1.27–1.66) for all-cause mortality, respectively. When compared with patients with normal nutrition, malnourished (defined by the CONUT score ≥2) patients conferred a 52% increased risk of MACEs. Additionally, per point CONUT score increment was associated with 15% and 11% higher risk of MACEs and all-cause mortality, respectively. Higher CONUT score independently predicts the MACEs all-cause mortality in CAD patients. Estimation of nutritional status using the CONUT score could be helpful for improving risk classification of CAD.

Nutritional Status of Coronary Artery Disease Patients—Preliminary Results

“…It was shown that nutritional status is correlated with the length of hospitalization in patients with hypertension and atrial fibrillation [ 26 , 27 ]. It is also associated with mortality in heart failure and coronary artery disease [ 28 , 29 , 30 , 31 , 32 ]. The available studies are mostly retrospective, so they are based only on the parameters available in everyday clinical practice.…”

The effect of a health belief model‐based education on nutritional behavior and biochemical factors of patients with myocardial infarction: A line follow‐up experimental study

“…2 Coronary artery diseases have become a global health concern and a major cause of death in developed and developing countries. 2,3 In addition to high mortality, they have social, psychological, and physical consequences. 3 Coronary artery diseases are the leading causes of death in Iran accounting for approximately 40% of deaths.…”

“…2,3 In addition to high mortality, they have social, psychological, and physical consequences. 3 Coronary artery diseases are the leading causes of death in Iran accounting for approximately 40% of deaths. 4 Myocardial infarction (MI) is a common cause of hospitalization.…”

“…Coronary artery diseases are classified into the category of atherosclerotic diseases and have an inflammatory nature and emerge with angina, myocardial infarction, and sudden cardiac death 2 . Coronary artery diseases have become a global health concern and a major cause of death in developed and developing countries 2,3 . In addition to high mortality, they have social, psychological, and physical consequences 3 .…”

Nutritional Status Predicts the Length of Stay and Mortality in Patients Undergoing Electrotherapy Procedures

“…In numerous studies, Czapla et al reported that nutritional status is correlated with the length of hospitalization in patients with hypertension and atrial fibrillation [ 13 , 14 ]. Moreover, nutritional status was also associated with mortality in patients with acute heart failure and coronary artery disease [ 15 , 16 , 17 , 18 , 19 ]. Furthermore, nutritional status is also associated with a better prognosis in chronic heart failure [ 20 ] and symptom severity in coronary heart disease [ 21 ].…”