Association of Condom Use, Sexual Behaviors, and Sexually Transmitted Infections With the Duration of Genital Human Papillomavirus Infection Among Adolescent Women

Shew, Marcia L.; Fortenberry, J. Dennis; Tu, Wanzhu; Juliar, Beth E.; Batteiger, Byron E.; Qadadri, Brahim; Brown, Darron R.

doi:10.1001/archpedi.160.2.151

Cited by 99 publications

(85 citation statements)

References 34 publications

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“…It is important to consider that these studies were conducted primarily among adolescent 14,41 or college-aged women 13,15 or women >35 years 16,17,19 of age and measured COC exposure as either current use or ''ever'' versus ''never'' use. Therefore, studies among younger women who are closer to the age of sexual debut may not have accumulated enough COC exposure time, whereas studies conducted among older women did not measure duration of use and combined long-and short-term users into a single ''ever use'' category, potentially diluting the association with HPV and precancer.…”

Section: Discussionmentioning

confidence: 99%

The association of hormonal contraceptive use and HPV prevalence

Marks

Gravitt

Gupta

et al. 2010

Intl Journal of Cancer

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Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the association of contraceptive use on the risk for prevalent HPV infection in a cohort of long-term hormonal contraceptive (HC) users. One thousand and seventy (n 5 1,070) HIV-negative women aged 20-37 from Thailand enrolled in a prospective study of the natural history of HPV. Baseline HPV genotype information, recency and duration of HC use, sexual behavior, other sexually transmitted infection (STI) information and cervical cytology and histology were assessed. At enrollment, 19.8% and 11.5% of women were infected with any HPV or any high-risk (HR)-HPV, respectively. After adjustment for age, current and past sexual risk behaviors, STI history and cytology, the use of COCs for >6 years was found to be associated with an increased risk of infection with any HPV [prevalence ratio (PR): 1.88 (1.21, 2.90)] and any HR-HPV [PR: 2.68 (1.47, 4.88)] as compared to never users. Recent, long-term COC use was associated with an increased risk for prevalent HPV infection independent of sexual behavior and cervical abnormalities. No similar association was observed for recent or long duration use of progestin-only contraceptives (i.e., depomedroxyprogesterone acetate). These data suggest that COC use may impact early upstream events in the natural history of HPV infection.Cervical cancer is the second most common cancer among women worldwide and a leading cause of cancer-related mortality in the developing world.1 Genital human papillomavirus (HPV) infections have been identified as a necessary cause of cervical cancer.2-4 More than 35 different types of HPVs infect the genital tract, with $18 types considered oncogenic or potentially oncogenic. 5,6 Roughly 291 million women worldwide are currently infected with one of these anogenital HPVs, and approximately 80% of women will be exposed at some point in their lifetime, making HPV the most common sexually transmitted infection (STI).7 However, a majority of HPV infections spontaneously resolve within 1-2 years postdetection. Therefore, other environmental, host and viral cofactors are likely required for the development of cervical cancer. Long-term use of combined oral contraceptives (COCs) has been shown in several case-control studies to be associated with cervical cancer diagnosis among HPV-positive women.9-12 However, it is unclear whether this association is driven by COCs' effect on carcinogenesis or on upstream subclinical endpoints of the natural history such as HPV acquisition and persistence as prospective studies assessing these relationships are inconsistent.

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Section: Discussionmentioning

confidence: 99%

The association of hormonal contraceptive use and HPV prevalence

Marks

Gravitt

Gupta

et al. 2010

Intl Journal of Cancer

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“…43,190 Consistent evidence supports condoms as reducing the risk of disease transmitted to and from the penile urethra, including gonorrhea, Chlamydia, trichomoniasis, hepatitis B, and HIV. [191][192][193][194][195] Emerging evidence also supports condoms as reducing the risk of acquiring diseases transmitted through skin or mucosal contact, including genital herpes simplex virus, 196,197 human papillomavirus, 198,199 and syphilis. 200 Because condoms protect against STIs, all sexually active adolescents should be encouraged to use condoms, regardless of whether an additional contraceptive method is used.…”

Section: Male Condomsmentioning

confidence: 99%

Contraception for Adolescents

Ott

Sucato²

2014

Pediatrics

234

132

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A working knowledge of contraception will assist the pediatrician in both sexual health promotion as well as treatment of common adolescent gynecologic problems. Best practices in adolescent anticipatory guidance and screening include a sexual health history, screening for pregnancy and sexually transmitted infections, counseling, and if indicated, providing access to contraceptives. Pediatricians’ long-term relationships with adolescents and families allow them to help promote healthy sexual decision-making, including abstinence and contraceptive use. Additionally, medical indications for contraception, such as acne, dysmenorrhea, and heavy menstrual bleeding, are frequently uncovered during adolescent visits. This technical report provides an evidence base for the accompanying policy statement and addresses key aspects of adolescent contraceptive use, including the following: (1) sexual history taking, confidentiality, and counseling; (2) adolescent data on the use and side effects of newer contraceptive methods; (3) new data on older contraceptive methods; and (4) evidence supporting the use of contraceptives in adolescent patients with complex medical conditions.

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“…1 Advantages include male involvement in the responsibility for contraception, easy accessibility by minors without a prescription, and low cost. Latex condoms also reduce STI transmission, with consistent evidence for the reduction of gonorrhea, chlamydia, trichomoniasis, [119][120][121][122][123] and hepatitis B and HIV transmission 124 and emerging evidence for the reduction of herpes simplex virus, 125,126 human papillomavirus, 127,128 and syphilis transmission. 129 However, condom use requires commitment at every sex act, tends to drop off over time, and is influenced by individual, relationship, and broader social factors.…”

Section: Male Condomsmentioning

confidence: 99%

Contraception for Adolescents

Braverman¹,

Adelman²,

Alderman³

et al. 2014

Pediatrics

301

103

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Contraception is a pillar in reducing adolescent pregnancy rates. The American Academy of Pediatrics recommends that pediatricians develop a working knowledge of contraception to help adolescents reduce risks of and negative health consequences related to unintended pregnancy. Over the past 10 years, a number of new contraceptive methods have become available to adolescents, newer guidance has been issued on existing contraceptive methods, and the evidence base for contraception for special populations (adolescents who have disabilities, are obese, are recipients of solid organ transplants, or are HIV infected) has expanded. The Academy has addressed contraception since 1980, and this policy statement updates the 2007 statement on contraception and adolescents. It provides the pediatrician with a description and rationale for best practices in counseling and prescribing contraception for adolescents. It is supported by an accompanying technical report.

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Association of Condom Use, Sexual Behaviors, and Sexually Transmitted Infections With the Duration of Genital Human Papillomavirus Infection Among Adolescent Women

Abstract: These findings support public health messages of reducing the number of sexual partners, promoting routine condom use, and frequent sexually transmitted infection screening that may be beneficial with HPV infections.

Cited by 99 publications

References 34 publications

The association of hormonal contraceptive use and HPV prevalence

The association of hormonal contraceptive use and HPV prevalence

Contraception for Adolescents

Contraception for Adolescents

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