Association of complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 vaccine

Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

“…Opsonization has also been hypothesized to contribute to viral reservoir maintenance in germinal centers via interaction with follicular dendritic cell-associated complement receptor 2 (CR2) ( 37 ). In line with this observation, hypofunctional CR2 polymorphisms have been shown to correlate with innate resistance to HIV-1 infection ( 38 ), and an association has been found between a single-nucleotide polymorphism (SNP) in the CR2 gene and susceptibility to infection among gp120-vaccinated individuals in a low-risk category ( 39 ).…”

IFNL4 genotype influences the rate of HIV-1 seroconversion in men who have sex with men

“…The vaccine candidate was based on two recombinant gp120 HIV-1 envelope proteins (MN and GNE8, AIDSVAX B/B; VaxGen) adsorbed onto 600 mg of alum. Individuals were eligible for entering the trial if they were not intravenous drug users, had anal intercourse during the preceding 12 months and not have a monogamous sexual relationship with an HIV-1 seronegative partner [ 15 , 16 ].…”

CD46 Genetic Variability and HIV-1 Infection Susceptibility

“…Samples are from available volunteers that became infected with HIV during the trial and a random sample of volunteers that remained uninfected. The main epidemiological and clinical characteristics of these volunteers have been previously described [41][42][43]. The present study included uninfected volunteers classified as having a high baseline risk of infection based on self-reported behaviors during the 6 months before enrollment.…”

“…Behavioral risk scores were calculated on the basis of the number of risk factors reported: unprotected receptive anal sex with an HIV-1-infected male partner; unprotected insertive anal sex with an HIV-1-infected male partner; unprotected receptive anal sex with an HIV-1-uninfected male partner; five or less acts of unprotected receptive anal sex with a male partner of unknown HIV-1 status; 10 or less sex partners; anal herpes; hepatitis A; use of poppers; and use of amphetamines. The inclusion criteria and main characteristics of these patients have been previously described in detail elsewhere [41][42][43].…”

“…This finding was replicated in an independent population at risk of infection through sexual exposure. CR2 was later associated with the rate of infection after HIV-1 vaccination with rgp120 protein [41]. One SNP in the CD46 gene was initially discarded due to a non-significant association with HIV-1 status after adjustment for multiple testing.…”