Association of Community-Acquired Pneumonia With Antipsychotic Drug Use in Elderly Patients

Trifirò, Gianluca; Gambassi, Giovanni; Şen, Elif; Caputi, Achille P.; Bagnardi, Vincenzo; Brea, José; Sturkenboom, Miriam

doi:10.7326/0003-4819-152-7-201004060-00006

Cited by 138 publications

(150 citation statements)

References 25 publications

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“…La prise de psychotropes, notamment des neuroleptiques, fré-quente dans la population gériatrique, a été associée à la survenue plus fréquente de pneumonies [8]. Plusieurs médicaments fréquemment utilisés en gériatrie favorisent la sécheresse buccale ;…”

Section: Physiopathologieunclassified

Infections pulmonaires du sujet âgé aux urgences

Breining

Cracco

2011

cah. année gerontol.

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Section: Physiopathologieunclassified

Infections pulmonaires du sujet âgé aux urgences

Breining

Cracco

2011

cah. année gerontol.

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“…The link is better established in elderly patients with a possible dose-dependent relationship and increased odds ratio in those treated with atypical antipsychotics [Trifirò et al 2010;Knol et al 2008]. More specifically, in the adult population an association between fatal pneumonia and clozapine therapy is also suggested.…”

Section: Introductionmentioning

confidence: 99%

Physical complications in early clozapine treatment: a case report and implications for safe monitoring

Patel

Allin²

2011

Therapeutic Advances in Psychopharmacology

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Treatment with the antipsychotic clozapine is often complicated by its wide-ranging and sometimes serious adverse effect profile. A link between clozapine therapy and diabetes is well established, although the onset and severity of glucose metabolism abnormalities is variable. Recent literature also suggests there may be an association between clozapine therapy and pneumonia. We review the relevant background literature and present a case of a patient with pre-existing type 2 diabetes mellitus and chronic obstructive pulmonary disease who presented with a diabetic emergency after a relatively short period of treatment with clozapine. He went on to develop pneumonia from which he died. We discuss the implications this case, and others alike, have for early routine physical health monitoring of this patient group.

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“…It is important to note that in elderly patients with dementia, AAPs are associated with an increased risk of pneumonia, cerebrovascular adverse effects, sedation, hip fractures and extrapyramidal side effects [14,16,17]. The DART-AD trial has shown that long-term use of antipsychotics for BPSD is associated with increased mortality compared to placebo [18].…”

Section: Indications Of Atypical Antipsychotics In the Elderly Editorialmentioning

confidence: 99%

Indications of atypical antipsychotics in the elderly

McKean¹,

Monasterio²

2014

Expert Review of Clinical Pharmacology

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Association of Community-Acquired Pneumonia With Antipsychotic Drug Use in Elderly Patients

Abstract: The use of either atypical or typical antipsychotic drugs in elderly patients is associated in a dose-dependent manner with risk for community-acquired pneumonia.

Cited by 138 publications

References 25 publications

Infections pulmonaires du sujet âgé aux urgences

Infections pulmonaires du sujet âgé aux urgences

Physical complications in early clozapine treatment: a case report and implications for safe monitoring

Indications of atypical antipsychotics in the elderly

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