Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia

Chen, Hui; Pu, Xiaoying; Zhang, Ruo-Peng; Zhou-Cun, A

doi:10.1007/s10815-014-0311-3

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…Multi-factorial disorders, including genetic abnormalities and/or environment influences, potentially affect fertility parameters. It is demonstrated that abnormalities of nuclear DNA [6], mitochondrial DNA [7] and RNA [8] in human being might either directly or indirectly affect the spermatogenesis. The impact of exposure to environmental factors would be indirect but significant.…”

Section: Introductionmentioning

confidence: 99%

A novel protein biochip screening serum anti-sperm antibody expression and natural pregnancy rate in a follow-up study in Chinese infertility

et al. 2020

Bioscience Reports

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Production of anti-sperm antibody (ASA) often suffers from autoimmune reaction against sperms in human infertility. The antibodies are measured in both blood and seminal plasma of males. Here, we reported a simple protein biochip methodology that takes advantage of a functionalized self-assembled monolayer modified by N-hydroxysuccinimide (NHS) and enables identification of anti-sperm antibody in Chinese male infertility. To validate this biochip platform, we immobilized purified sperm protein on the biochip surface and tested a variety of parameters in quality controls for the protein assay, respectively. Then, we analyzed serum samples from 368 patients with infertility and 116 healthy donors by means of this biochip simultaneously. We found that positive rate of serum ASA was 20.92% (77/368) in the cases and 1.72% (2/116) in the controls, respectively. Furthermore, we further corroborated the biochip assay in comparison with ELISA method. We found that both methods were compatible for the detection of serum ASA in the patients. In addition, a follow-up study for natural conception in ASA-positive and ASA-negative patients was conducted. The result showed a significant correlation between serum ASA expression and natural pregnancy rate 6.5% in ASA-positive patients while 18.9% in ASA-negative patients, indicating the potential roles of ASA in naturally reproductive processes.

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Section: Introductionmentioning

confidence: 99%

A novel protein biochip screening serum anti-sperm antibody expression and natural pregnancy rate in a follow-up study in Chinese infertility

et al. 2020

Bioscience Reports

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“…The genetic factors involved in male infertility include Y chromosome microdeletions, chromosomal or monogenic disorders, mitochondrial DNA (MTDNA) mutations, imprinting disorders, or endocrine disorders of genetic origin [4]. Spermatogenesis impairment is the most common form of male infertility, and many genetic factors are involved in impaired spermatogenesis [4,5].…”

Section: Introductionmentioning

confidence: 99%

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

et al. 2015

J Assist Reprod Genet

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Purpose This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folaterelated enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. Methods The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. Results We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. Conclusions There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.

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“…In humans, the level of MLH1 methylation in NOA patients is significantly higher than that in healthy subjects and is positively correlated with the level of reactive oxygen species (ROS; Gunes et al, ). Moreover, a recent human study indicated that single nucleotide polymorphisms (SNPs) of PARP1 are highly associated with oligospermia (Chen, Pu, Zhang, & A, ). In mice, the requirements of HSP90AA1, MAPK1 and PRMT5 for spermatogenesis have been shown, and the absence of one of these genes leads to germ cell reduction or inhibition of proliferation (Grad et al, ; Thuillier et al, ; Wang et al, ).…”

Section: Discussionmentioning

confidence: 99%

Microarray meta‐analysis identifies candidate genes for human spermatogenic arrest

Fang

Chen

et al. 2019

Andrologia

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Male infertility affects approximately half of couples who have difficulty becoming pregnant, and its prevalence is continuously rising. Many studies have been performed using animal testes to reveal the mechanisms of male infertility, but few studies have investigated human testes due to various limitations. The aim of this study was to investigate the gene expression profile of impaired human testes through a meta‐analysis of microarray data sets, which was accomplished by using 178 human testis samples and 7 microarray data sets. Impaired testes were categorised into four pathological phenotypes or the normal phenotype based on their Johnsen score. Then, a meta‐analysis was performed to screen out the differentially expressed genes (DEGs) in each phenotype. The DEGs were used in a subsequent bioinformatics analysis. Our results identified several novel hub genes and pathways and suggested that G1 mitotic cell cycle arrest was a remarkable feature in pre‐meiotic arrest. Furthermore, fifteen p53‐interacting proteins, such as ABL1 and HDAC2, whose roles in spermatogenesis have not been well characterised, were selected from the DEGs through a strict screening procedure.

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Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia

Cited by 8 publications

References 32 publications

A novel protein biochip screening serum anti-sperm antibody expression and natural pregnancy rate in a follow-up study in Chinese infertility

A novel protein biochip screening serum anti-sperm antibody expression and natural pregnancy rate in a follow-up study in Chinese infertility

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

Microarray meta‐analysis identifies candidate genes for human spermatogenic arrest

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