Association of Common Polymorphisms in the Interleukin-1 Beta Gene with Hepatocellular Carcinoma in Caucasian Patients with Chronic Hepatitis B

Fischer, Janett; Liu, Shuang; Koukoulioti, Eleni; Müller, Tobias; Fueloep, B; Heyne, R.; Eslam, Mohammed; George, Jacob; Finkelmeier, Fabian; Waidmann, Oliver; Berg, Thomas; Boemmel, Florian van

doi:10.3390/pathogens12010054

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…The interactions between the immune system and other host factors are critical for HCC development in CHB patients. In this case, alterations in some genes such as signal transducer and activator of transcription 3 (STAT3), STAT4, chemokine (C-X-C motif) ligand 2 (CXCL2), and interleukin-1 beta (IL-1β) are described (4)(5)(6).…”

Section: Key Pointmentioning

confidence: 99%

Association of viral load and autophagy-related genes polymorphisms with hepatitis B virus pre-core/core mutations in chronic hepatitis B virus Iraqi patients

Jwaziri,

Esghaei,

Karbalaie Niya

et al. 2023

Immunopathol Persa

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Introduction: Chronic hepatitis B (CHB) is a global concern due to its association with cirrhosis and hepatocellular carcinoma (HCC) development. The interplay between viral load, the immune system, and host factors is critical in tumorigenesis. Autophagy is a significant contributor to immune system function, since vitamin D plays an important role in this context. Objectives: The objective of this study was to assess the association between ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, viral load, and vitamin D with HBV pre-C/C mutations in Iraqi patients with CHB. Patients and Methods: In this cross-sectional study, a total of 134 CHB patients were evaluated for ATG polymorphisms, viral load, and vitamin D levels. Blood samples were collected after obtaining ethical consent, and the mutations were analyzed using polymerase chain reaction (PCR) followed by Sanger sequencing. Serum samples from CHB patients were used for viral load and vitamin D assessment. Results: The evaluation of patients revealed that 67 (44.6%) were male and 83 (55.4%) were female, with a mean age of 36±12.7 years and a mean duration of infection of 5.2±4.8 years. Mutations in pre-C/C were observed in 20% (27/134) of the patients. There was a significant association between all evaluated ATG polymorphisms and pre-C/C mutants (P<0.05). Furthermore, there was an association between viral load and mutations in pre-C/C (P=0.03), while no statistically significant difference was found between vitamin D levels and pre-core/core mutants or viral load. Conclusion: Our study demonstrates a higher frequency of ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, as well as a higher viral load in Iraqi CHB patients with HBV pre-C/C mutations.

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Section: Key Pointmentioning

confidence: 99%

Association of viral load and autophagy-related genes polymorphisms with hepatitis B virus pre-core/core mutations in chronic hepatitis B virus Iraqi patients

Jwaziri,

Esghaei,

Karbalaie Niya

et al. 2023

Immunopathol Persa

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Effect of genetic polymorphisms of interleukin‐1 beta on the microscopic portal vein invasion and prognosis of hepatocellular carcinoma

Namba,

Kobayashi,

Tadokoro

et al. 2024

J Hepato Biliary Pancreat

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BackgroundSeveral studies have demonstrated a relationship between genetic polymorphisms of interleukin‐1 beta (IL‐1β) and cancer development; however, their influence on cancer prognosis is unknown. In the present study, we aimed to evaluate the impact of IL‐1β single nucleotide polymorphisms on the hematogenous dissemination and prognosis of hepatocellular carcinoma.MethodsWe conducted a retrospective cohort study including patients with hepatocellular carcinoma who underwent primary liver resection at our hospital between April 2015 and December 2018. The primary endpoints were overall and recurrence‐free survival. Secondary endpoints were microscopic portal vein invasion and number of circulating tumor cells.ResultsA total of 148 patients were included, 32 with rs16944 A/A genotype. A/A genotype was associated with microscopic portal vein invasion and number of circulating tumor cells (p = .03 and .04). In multivariate analysis, A/A genotype, alpha‐fetoprotein level, and number of circulating tumor cells were associated with microscopic portal vein invasion (p = .01, .01, and <.01). A/A genotype, Child‐Pugh B, and intraoperative blood loss were independent predictive factors for overall survival (p = .02, <.01, and <.01).ConclusionsOur results indicate that the IL‐1β rs16944 A/A genotype is involved in number of circulating tumor cells, microscopic portal vein invasion, and prognosis in HCC.

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Multifunctional roles of inflammation and its causative factors in primary liver cancer: A literature review

Chen,

Huang,

Jiang

et al. 2023

World J Hepatol

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Primary liver cancer is a severe and complex disease, leading to 800000 global deaths annually. Emerging evidence suggests that inflammation is one of the critical factors in the development of hepatocellular carcinoma (HCC). Patients with viral hepatitis, alcoholic hepatitis, and steatohepatitis symptoms are at higher risk of developing HCC. However, not all inflammatory factors have a pathogenic function in HCC development. The current study describes the process and mechanism of hepatitis development and its progression to HCC, particularly focusing on viral hepatitis, alcoholic hepatitis, and steatohepatitis. Furthermore, the roles of some essential inflammatory cytokines in HCC progression are described in addition to a summary of future research directions.

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Association of Common Polymorphisms in the Interleukin-1 Beta Gene with Hepatocellular Carcinoma in Caucasian Patients with Chronic Hepatitis B

Cited by 3 publications

References 47 publications

Association of viral load and autophagy-related genes polymorphisms with hepatitis B virus pre-core/core mutations in chronic hepatitis B virus Iraqi patients

Association of viral load and autophagy-related genes polymorphisms with hepatitis B virus pre-core/core mutations in chronic hepatitis B virus Iraqi patients

Effect of genetic polymorphisms of interleukin‐1 beta on the microscopic portal vein invasion and prognosis of hepatocellular carcinoma

Multifunctional roles of inflammation and its causative factors in primary liver cancer: A literature review

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