Association of COL1A1 polymorphism with subchondral bone degeneration of the temporomandibular joint

Luo, Sai; Long, Xing; Deng, Mohong; Meng, Qinggong; Jin, Ke; Guo, Huilin

doi:10.1016/j.ijom.2016.06.010

Cited by 9 publications

(2 citation statements)

References 31 publications

(61 reference statements)

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“…However, these studies have obtained conflicting results. Lian K et al [ 22 ] and Luo S et al [ 23 ] reported a positive relationship between incidence of OA or IVDD and G allele at rs1800012 site. Suprisingly, Tilkeridis et al [ 24 ] and Pluijm et al [ 25 ] got an opposite conclusion.…”

Section: Introductionmentioning

confidence: 99%

Association of COL1A1 rs1800012 polymorphism with musculoskeletal degenerative diseases: a meta-analysis

Zhong

Huang

et al. 2017

Oncotarget

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It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 gene might be linked to the susceptibility of musculoskeletal degenerative diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD). However, the data from different studies is contradictory. Here we aimed to comprehensively summarize and clarify the relationship between the SNP and musculoskeletal degenerative diseases. Seven eligible studies including 1339 cases and 5406 controls were screened out from PubMed, Web Of Science and Cochrane library databases. Significant association was identified in sub group analysis of IVDD in homozygote model (GG versus TT: OR = 0.33, 95% CI 0.14–0.78, P = 0.012), heterozygote model (GT versus TT: OR = 0.29, 95% CI 0.11–0.72, P = 0.008) and dominant model (GG/GT versus TT: OR = 0.31, 95% CI 0.13–0.74, P = 0.008). Additionally, significant relationship was also found in sub group analysis of severe degree of IVDD in homozygote model (GG versus TT: OR = 0.37, 95% CI 0.15–0.91, P = 0.031), heterozygote model (GT versus TT: OR = 0.33, 95% CI 0.13–0.87,P = 0.024) and dominant model (GG/GT versus TT: OR = 0.36, 95% CI 0.14–0.88, P = 0.025). Although no significance was observed, there is a trend that the more G allele at COL1A1 rs1800012 site, the less possibility of IVDD and severe IVDD would happen. Our results indicate that COL1A1 rs1800012 polymorphism associates with the susceptibility of IVDD. However, this polymorphism may not be associated with OA risk.

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Section: Introductionmentioning

confidence: 99%

Association of COL1A1 rs1800012 polymorphism with musculoskeletal degenerative diseases: a meta-analysis

Zhong

Huang

et al. 2017

Oncotarget

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“…The COL1A1 gene's genetic polymorphism has a clinically significant effect on bone remodeling (27) . The periosteum of the mandibular bone, the mandibular condylar cartilage, the perichondrium of Meckel's cartilage, and the bone collar of the cranial base cartilage all contain COL1A1 in midterm human fetuses (28).…”

Section: Discussionmentioning

confidence: 99%

Gene polymorphisms for patients with Class III malocclusion. A pilot study

Bahya,

Abid,

Alsahafi

2024

J Bagh Coll Dent

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Background: The interactions of genetic and environmental factors may account for the variability in the expression of malocclusion. The study of malocclusion etiology is fundamental to understand the biology underlying craniofacial growth and dental relations. Understanding biology will improve progress toward effective treatment and prevention, thereby decreasing the burden of this condition. Aims: The present study was set out to investigate the association of the single nucleotide polymorphisms (SNPs) in different genes (rs2249492 in COLA1A, rs4434184 in SOX2, rs2162540 in FGFR2, rs11696257 in MAFB, and rs881301 in FGFR1) with Class III malocclusion. Materials and Methods: A total of 10 patients, comprising 5 with Skeletal Class I and 5 with Skeletal Class III malocclusion, were included in the present study. Salivary DNA samples were collected and analyzed using Sanger sequencing. Digital tracing was performed on lateral cephalometric radiographs by using AutoCAD software for digitization to assess the anterio-posterior and vertical relationship of the maxillary and mandibular arch. Results: Out of five genes polymorphisms only two genes polymorphisms (SOX2 and FGFR1) showed an association with Cl.III malocclusion. Conclusion: This study reveals that SOX2 and FGFR1 genetic polymorphisms may be responsible for Class III malocclusion. However, more study with a larger participant pool is required to confirm these findings.

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TMJ arthrosis: does the occlusal relationship really interfere? A comparison between cone beam computed tomography and dried skulls

et al. 2018

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Association of COL1A1 polymorphism with subchondral bone degeneration of the temporomandibular joint

Cited by 9 publications

References 31 publications

Association of COL1A1 rs1800012 polymorphism with musculoskeletal degenerative diseases: a meta-analysis

Association of COL1A1 rs1800012 polymorphism with musculoskeletal degenerative diseases: a meta-analysis

Gene polymorphisms for patients with Class III malocclusion. A pilot study

TMJ arthrosis: does the occlusal relationship really interfere? A comparison between cone beam computed tomography and dried skulls

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