Association of coeliac disease with primary biliary cirrhosis in Poland

Habior, Andrzej; Lewartowska, Aleksandra; Orłowska, Janina; Zych, W; Sankowska, Monika; Bauer, Alicja; Butruk, E

doi:10.1097/00042737-200302000-00009

Cited by 21 publications

(16 citation statements)

References 23 publications

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“…A threefold or greater increase in risk of PBC in people with CD compared with the general population has been recently demonstrated [66,67]. There are, however, some reports that do not confirm the association between CD and PBC [68,69]. Given the small number of patients studied in these reports, the association between CD and PBC can be reasonably accepted.…”

Section: Primary Biliary Cirrhosismentioning

confidence: 94%

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

Volta

2008

Clinic Rev Allerg Immunol

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Abnormalities of liver function are one of the manifold extraintestinal manifestations of celiac disease. Although the spectrum of liver manifestations associated with celiac disease is particularly wide, two main forms of liver damage namely, cryptogenic and autoimmune, appear to be strictly related to gluten-sensitive enteropathy. The most frequent finding is represented by a cryptogenic hypertransaminasemia, observed in about a half of untreated celiac patients, as an expression of a mild liver dysfunction with a histological picture of nonspecific reactive hepatitis (celiac hepatitis) reverting to normal after 6-12 months of a strict gluten-free diet. In a few cases, when celiac disease is diagnosed, a more severe liver injury, characterized by a cryptogenic chronic hepatitis or liver cirrhosis, is present. In these patients, liver damage can still improve after a gluten-free diet institution. Moreover, a close association between celiac disease and autoimmune liver disorders has been widely demonstrated. Indeed, celiac disease has been found in 3-7% of patients with primary biliary cirrhosis, in 3-6% with autoimmune hepatitis, and in 2-3% with primary sclerosing cholangitis. Differently from cryptogenic liver injury, autoimmune liver dysfunction, found in celiac disease, does not usually improve after a gluten-free diet. Presently, it is difficult to establish if the two main kinds of liver injury found in celiac disease (cryptogenic and autoimmune) are discrete entities with a different pathogenesis or if they are an expression of the same disorder where genetic factors and the duration of gluten exposure may determine the severity and the pattern of liver injury.

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Section: Primary Biliary Cirrhosismentioning

confidence: 94%

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

Volta

2008

Clinic Rev Allerg Immunol

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“…With the exception of two negative studies, consistent association between PBC and CD has been shown. [36,37] In a recent review of CD and liver disease, percentage of biopsy confirmed CD cases among the PBC population ranged from 1.3 to 7%. [38] The largest study included greater than 13,800 CD patients from the Swedish national register and confirmed the association.…”

Section: Associated Autoimmune Liver Diseasementioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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“…The association of coeliac disease (CD) with various forms of liver disease has been described in several European and North American populations 1–14 . In particular, an increased prevalence of the autoimmune cholestatic liver diseases; primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), in patients with CD has been reported.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune cholestatic liver disease in people with coeliac disease: a population‐based study of their association

Lawson

West

Aithal

et al. 2005

Aliment Pharmacol Ther

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Summary Background : Population data supporting an association between the autoimmune cholestatic liver diseases, primary biliary cirrhosis and primary sclerosing cholangitis and coeliac disease, is limited and at times contradictory. Aim : To explore the relationship between coeliac disease and both primary biliary cirrhosis and primary sclerosing cholangitis within the General Practice Research Database, a UK‐based longitudinal primary care database. Methods : We identified 4732 people with diagnosed coeliac disease and 23 620 age‐ and sex‐matched controls within the General Practice Research Database. We calculated the prevalence of primary biliary cirrhosis and primary sclerosing cholangitis for both the coeliac disease and control group. Results : There was a higher prevalence of primary biliary cirrhosis in adults with coeliac disease, compared with controls [0.17% vs. 0.05%, odds ratio 3.63 (95% confidence interval: 1.46–9.04)]. Primary sclerosing cholangitis was also more common in the coeliac disease group [0.04% vs. 0%, fishers exact test (P = 0.03)]. Conclusions : There was a threefold or greater increase in risk of both primary biliary cirrhosis and primary sclerosing cholangitis in people with coeliac disease compared with the general population. The association with primary biliary cirrhosis was weaker than in some reports and it is difficult on the basis of this study to justify screening patients with coeliac disease for either primary biliary cirrhosis or primary sclerosing cholangitis.

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Association of coeliac disease with primary biliary cirrhosis in Poland

Cited by 21 publications

References 23 publications

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Autoimmune cholestatic liver disease in people with coeliac disease: a population‐based study of their association

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