Association of Cirrhosis and Cardiomyopathy

Sezgin, Burcu; Cindoğlu, Çiğdem; Uyanıkoğlu, Ahmet; Yenice, Necati

doi:10.5005/jp-journals-10018-1291

Cited by 2 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that age is associated with a higher prevalence of CCM (p-value=0.0439). Findings of various studies [ 8 - 10 ] have also demonstrated that age is one of the risk factors in such patients though another study by Uyanikoglu et al [ 11 ] has shown no significant correlation between age and CCM.…”

Section: Discussionmentioning

confidence: 99%

“…More often, the warning bell of CCM is ‘rung’ by QTc prolongation in electrocardiogram. A significant increase of QTc within normal limits has been found in compensated cirrhotic patients in comparison to the control group [ 11 ]. There is a strong correlation between QTc and high serum bilirubin levels and cardiac arrhythmia [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with Child-Pugh C have prolonged QTc interval with most of them showing Grade II DD. LVDD is caused by a delay in the left ventricular filling either due to ventricular hypertrophy, disruption of collagen structure, or subendocardial oedema [ 11 ]. Patients with prolonged QTc interval have usually lower survival than their normal counterparts.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluating Diastolic Dysfunction as an Indicator of Cirrhotic Cardiomyopathy in Decompensated Chronic Liver Disease

Kumar,

Shikoh,

Rani

2024

Cureus

View full text Add to dashboard Cite

Background: The clinical syndrome of cirrhotic cardiomyopathy (CCM) occurs quite frequently in decompensated chronic liver disease (DCLD) patients without any prior incidence. The compromised life expectancy under such conditions was the key that prompted us to conduct this study. Purpose: This study was planned to study the prevalence of diastolic dysfunction in chronic liver disease patients, to understand the diagnostic criteria of left ventricular diastolic dysfunction (LVDD) in cirrhotic patients, and to evaluate its occurrence as an early indicator of CCM. Methods: A hospital-based, cross-sectional study was conducted on 158 patients, admitted to the Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, India, who conformed to our criteria for inclusion and exclusion. The study period was for 18 months. The subjects were clinically and radiologically diagnosed with chronic liver disease. Regression analysis for variables was performed to score the effects of potential variables with outcomes for diastolic dysfunction (DD) prediction. Results: Out of 158 patients, 116 belonged to the age group of 31-60 years, pronouncing age to be a significant factor for LVDD. Fifty-three subjects had serum bilirubin levels >2mg/dL and we found serum bilirubin levels to bear a significant correlation with LVDD by exhibiting a p-value <0.0001. Both the Child-Turcotte-Pugh score class (p-value=0.0180) and QTc (p-value <0.0001) bear significant correlation with the development of LVDD, which is also evident from their area under the curve (AUC) values of 0.64 in the receiver operating characteristic (ROC) curve. Conclusion: Our study concludes that LVDD is an early indicator for assessing the severity of liver cirrhosis in DCLD. The correlation of DCLD with prolonged QTc could predispose patients with DCLD to ventricular arrhythmias. Hence, such patients should undergo serum bilirubin tests, and electrocardiographic checks at regular intervals for early detection, to increase their overall survival rates.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating Diastolic Dysfunction as an Indicator of Cirrhotic Cardiomyopathy in Decompensated Chronic Liver Disease

Kumar,

Shikoh,

Rani

2024

Cureus

View full text Add to dashboard Cite

show abstract

QTc prolongation in patients of cirrhosis and its relation with disease severity: An observational study from a rural teaching hospital

Bhardwaj

Joshi

Sharma

et al. 2020

J Family Med Prim Care

View full text Add to dashboard Cite

Introduction: Cirrhotic cardiomyopathy is characterised by increased baseline cardiac output, systolic and diastolic dysfunction, diminished cardiovascular response to stressful stimuli and electrophysiological abnormalities in patients of cirrhosis in the absence of any underlying cardiac disease. QTc prolongation has been described as a common electrocardiographic abnormality in cirrhosis patients. Aims and Objectives: This study was done to evaluate the prevalence of QTc changes in patients of cirrhosis coming to a rural tertiary care centre and to analyse its correlation with disease severity. Materials and Methods: The present study was conducted on 100 patients suffering from cirrhosis of liver presented to the department of medicine. Around 100 age and sex-matched individuals were recruited as controls. The Child-Pugh score was used to determine the disease severity in cirrhosis patients. Standard 12-lead ECG was recorded in all cases and controls. Results: Prolongation of QTc interval on ECG was observed in the majority (80%) of cirrhosis patients and it was significantly higher as compared to the healthy controls ( P <0.01). The prolongation of QTc was significantly associated with the duration of disease ( P <0.05) and disease severity as measured by the Child-Pugh score ( P <0.01). Conclusion: QTc prolongation on ECG may be an early marker of cardiac involvement in patients of cirrhosis and is significantly associated with disease severity.

show abstract

Association of Cirrhosis and Cardiomyopathy

Cited by 2 publications

References 17 publications

Evaluating Diastolic Dysfunction as an Indicator of Cirrhotic Cardiomyopathy in Decompensated Chronic Liver Disease

Evaluating Diastolic Dysfunction as an Indicator of Cirrhotic Cardiomyopathy in Decompensated Chronic Liver Disease

QTc prolongation in patients of cirrhosis and its relation with disease severity: An observational study from a rural teaching hospital

Contact Info

Product

Resources

About