Association of Circulating Retinol and Α-TOH Levels with Cognitive Function in Aging Subject with Type 2 Diabetes Mellitus

Huang, Xiaochen; Guo, Yujie; Li, P.; Ma, Xiaojun; Dong, Shengqi; Hu, Hejing; Li, Y.; Yuan, Linhong

doi:10.1007/s12603-020-1328-1

Cited by 5 publications

(1 citation statement)

References 53 publications

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“…Current evidence suggests a positive association between low circulating vitamin A levels and AD [51][52][53][54]. More recent studies extend this finding by demonstrating that vitamin A is also reduced in elderly patients with mild and moderate cognitive impairment (MCI) [14,55,56,89]. Interestingly, others have found that not serum retinol levels, but its precursor carotenoids are significantly associated with cognitive performance in centenarians (i.e., individuals with age ≥ 98) [90].…”

Section: Vitamin Amentioning

confidence: 95%

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

et al. 2023

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Alzheimer’s disease (AD) is the most common type of dementia that affects millions of individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized by memory loss, impaired learning and thinking, and difficulty in performing regular daily activities. Despite nearly two decades of collective efforts to develop novel medications that can prevent or halt the disease progression, we remain faced with only a few options with limited effectiveness. There has been a recent growth of interest in the role of nutrition in brain health as we begin to gain a better understanding of what and how nutrients affect hormonal and neural actions that not only can lead to typical cardiovascular or metabolic diseases but also an array of neurological and psychiatric disorders. Vitamins and minerals, also known as micronutrients, are elements that are indispensable for functions including nutrient metabolism, immune surveillance, cell development, neurotransmission, and antioxidant and anti-inflammatory properties. In this review, we provide an overview on some of the most common vitamins and minerals and discuss what current studies have revealed on the link between these essential micronutrients and cognitive performance or AD.

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