Association of circulating omentin-1 level with lung cancer in smokers

Abstract

Background: Omentin has recently been considered as an adipokine secreted from visceral fat and is expressed in the lungs, heart, ovary etc. Various studies have shown that omentin may have an anti-inflammatory role in the inflammatory process and the amount of omentin alters in some cancers, such as colorectal, prostate and renal cells cancers, changes. The serum level of omentin, however, remains unknown in non-patient smokers and the smokers afflicted with lung cancer. Therefore, this study examines the serum levels of omentin in smokers suffering from lung cancer. Methods: The amount of serum omentin was measured in 45 patients with lung cancer and 61 age - and sex - matched controls (30 smokers and 31 non-smokers) using enzyme-linked immunosorbent assay (ELISA) kit. Data were analyzed using SPSS-16, and oneway analysis of variance and Scheffe post hoc test were used to determine and compare the serum levels of omentin in different types of lung malignancies. Significance level was set at p≤0.05. Results: The amount of circulating omentin for healthy non-smokers and non-patient smokers was 3.55±0.57 ng/l and 5.43±1.95 ng/l, respectively (p<0.001). The serum level of omentin was 3.63±0.70 ng/l for smokers afflicted with cancer (p<0.001 compared with nonpatient smokers: 5.43±1.95). Conclusion: The meaningful decrease in omentin levels in smokers with lung cancer can be considered as a risk factor in smokers and can use as a significant factor in the prognosis of lung cancer in these people.

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

“…Moreover, omentin concentration is inversely correlated with BMI and percent body fat [ 260 , 261 , 265 , 266 ]. An increase in serum omentin levels correlated with a decrease in serum CRP levels and suppression of TNF-α function, confirming the link between ITLN and inflammation [ 267 ]. In addition, Escote et al [ 261 ] noted that omentin-1 shows a gender dimorphism, as higher levels were observed in women than in men.…”

A systematic review and Bayesian meta-analysis assessing intelectin-1 in cancer patients and healthy individuals

“…Overall, only 8 studies adequately described the characteristics of the assay ( Table 1 ), while 5 studies did not report any characteristics (e.g., sensitivity, range) and 7 were inconsistent (e.g., reported data were outside the assay range) or failed to give sufficient details (e.g., the manufacturer’s reported intra- and inter-assay coefficient of variation). Interestingly, only 5 studies passed the methodological quality control and provided high-quality data ( 32 , 35 , 36 , 40 , 41 ) as the assay characteristics were reported adequately and the blood was collected in the morning, after an overnight fast.…”

“…A total of 10 studies collected blood in the morning after an overnight fast, 3 studies reported that blood was collected in a fasted state (without mentioning the period of the day), 1 study suggested that blood was collected in the morning (but did not indicate whether participants fasted), 3 studies stated non-specific/ were outside the assay range) or failed to give sufficient details (e.g., the manufacturer's reported intra-and inter-assay coefficient of variation). Interestingly, only 5 studies passed the methodological quality control and provided high-quality data (32,35,36,40,41) as the assay characteristics were reported adequately and the blood was collected in the morning, after an overnight fast.…”

The Influence of Biologically Active Substances Secreted by the Adipose Tissue on Endometrial Cancer

“…Leptin predominantly through JAK/STAT pathway which modulates PI3K/AKT3 signaling [62,63] Visfatin promotion of cell growth via NF-κB/Notch1 [64] Galectin MAPK family signal transduction and cell proliferation [65] Adiponectin inhibits cell proliferation via ERK1/2-MAPK pathway [66] Omentin Stimulates apoptosis through the activation of JAK/STAT signaling pathway [67] Vaspin inhibits proliferation and chemokinesis through the inhibition of NF-κB/Notch1 pathway [68]…”