Association of circulating BMP9 with coronary heart disease and hypertension in Chinese populations

Abstract

Background Bone morphogenetic protein9 (BMP9) has been reported to have a role in vascular development. However, there is still a lack of information regarding the association between circulating BMP9 levels and cardiovascular disease in humans. The goal of this study is to measure circulating BMP9 concentrations in patients with essential hypertension (HTN), coronary heart disease (CHD) and HTN + CHD, and evaluates the relationship between circulating BMP9 and these cardiovascular diseases. Methods A total of 417 individuals were recruited for this cross-sectional study from June 2015 to December 2017. These subjects were screened for HTN and CHD. Circulating BMP9 concentrations were measured by ELISA. Results Circulating BMP9 concentrations were significantly low in HTN, CHD and HTN + CHD individuals relative to those of the healthy individuals. Circulating BMP9 correlated negatively with SBP, FIns and HOMA- IR in HTN patients and correlated negatively with FBG and 2 h-BG in CHD patients. In both HTN and CHD patients, circulating BMP9 correlated negatively with BMI, WHR, FAT%, BP and TG. Multivariate logistic regression analysis showed that circulating BMP9 levels were associated with HTN, HTN + CHD and CHD. Individuals with low quartile of circulating BMP9 had a significantly high risk of HTN or/and CHD as compared with those in high quartile. Conclusions BMP9 is likely to be a biomarker for cardiovascular disease in humans, and it may play a role in the progression of cardiovascular disease. Trial registration ChiCTR-OPC-14005324 . Electronic supplementary material The online version of this article (10.1186/s12872-019-1095-2) contains supplementary material, which is available to authorized users.

Insights into bone morphogenetic proteins in cardiovascular diseases

“…One cross-sectional study showed that circulating BMP-9 levels were negatively correlated with hypertension and CAD (Liu et al, 2019). In a recent study, and BMP-10 double knockout mice, and they found dramatic changes, such as a thinner vascular smooth muscle layer, decreased blood pressure and dilated aortic, pulmonary, cardiac arteries and mesenteric arteries (Wang et al, 2021).…”

BMP9 and BMP10: Two close vascular quiescence partners that stand out

“…BMP9 circulating levels have also been shown to be significantly lower in patients with vascular malformations, hypertension, and coronary heart disease 98,140,141 . Elevated circulating BMP10 has also been shown to predict atrial fibrillation ablation 142 …”

“…BMP9 circulating levels have also been shown to be significantly lower in patients with vascular malformations, hypertension, and coronary heart disease. 98,140,141 Elevated circulating BMP10 has also been shown to predict atrial fibrillation ablation. 142 Circulating BMP9 has also been measured in a small cohort (n = 10) of patients with systemic inflammatory response syndrome (SIRS) and sepsis, and was found to be significantly reduced compared to healthy controls.…”

Early Mid-pregnancy Blood-Based Proteins as Possible Biomarkers of Increased Infant Birth Size in Sex-Stratified Analyses

“…GDF-2 is produced by the liver and maintains vascular quiescence, promotes osteogenesis, and is associated with improved glucose metabolism and insulin sensitivity [ 56 , 57 ]. GDF-2 has been suggested as a biomarker for cardiovascular disease since its levels are lower in individuals with essential hypertension and coronary heart disease compared with controls [ 58 ]. In a mouse model, fetal GDF-2 levels increase until birth and remain high 3 weeks postnatal, indicating a role for GDF-2 in development [ 59 ].…”