Association of Cigarette Smoking With Superoxide Dismutase Enzyme Levels in Subjects With Chronic Periodontitis

Agnihotri, Rupali; Pandurang, Pratibha; Kamath, Shobha; Goyal, Rahul; Ballal, Suhas; Shanbhogue, Ashwini Y.; Kamath, Ullas; Bhat, GS; Bhat, Kumar M.R.

doi:10.1902/jop.2009.080545

Cited by 58 publications

(81 citation statements)

References 26 publications

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“…In the present study, lower GPx activity in chronic periodontitis group is observed than in controls. Similar findings were reported by studies [26,32]. Guentsch et al [36] have showed that periodontally healthy subjects demonstrated significantly lower levels of GP x than the periodontitis group including smokers.…”

Section: Discussionsupporting

confidence: 82%

“…Smoking is associated with altered expression and activity of antioxidant enzymes. According to the studies [32,33] cigarette smoking is associated with a significant decrease in the level of SOD, however some other studies [34,35] have documented that compared to non smoker controls the bidi smokers have shown increased erythrocyte SOD activity. We have observed a relatively higher SOD Values are mean ± SD * P values are obtained using one way analysis of variance (ANOVA) with Tukey's correction for multiple group comparisons.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein.The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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“…While Panjamurthy et al (52) reported significantly higher SOD levels in periodontitis compared to controls, Akalın et al (54,55) reported lower SOD in periodontitis patients. In our study, the decreases in SOD levels in rats affected by periodontitis were not statistically significant.…”

Section: Discussionmentioning

confidence: 95%

“…Studies on the association between periodontitis severity and antioxidant enzyme levels have yielded inconsistent results (51)(52)(53). While Panjamurthy et al (52) reported significantly higher SOD levels in periodontitis compared to controls, Akalın et al (54,55) reported lower SOD in periodontitis patients.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

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The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties.Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease.

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“…As indicated by Agnihotri's study, which compared average levels of superoxide dismutase (SOD) in the GCF and saliva of smokers and non-smokers with periodontitis, there was a significant reduction in superoxide dismutase levels in smokers compared to non-smoker subjects. Moreover, it was proved that there was a gradual decrease in the levels of SOD of the GCF and saliva from light smoking to heavy smoking (11).…”

Section: Introductionmentioning

confidence: 98%

Evaluation of Salivary Total Antioxidant Capacity in Smokers with Severe Chronic Periodontitis

Shirzaiy

Ladiz

Dalirsani

et al. 2017

Int J High Risk Behav Addict

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Background: Smoking leads to changes in immune reaction and total antioxidant capacity. Smoking, through dysfunction of antioxidant system, plays an important role in the pathogenesis of inflammatory diseases. Objectives: The current study aimed at comparing salivary antioxidant capacity in smokers and non-smokers with severe chronic periodontitis. Patients and Methods:In this case-control study, among patients referred to Zahedan School of Dentistry without any systemic diseases, 64 patients with severe chronic periodontitis, including 27 smokers as the case group and 37 non-smokers as the control group, were selected. Stimulated salivary samples were collected and total antioxidant levels were evaluated through the Ferric reducing antioxidant power (FRAP) technique. All analyses were performed by SPSS (Ver.18) using Student's t-test, Mann Whitney test or analysis of variance (ANOVA) with significance level of 0.05 in all of the tests.

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Association of Cigarette Smoking With Superoxide Dismutase Enzyme Levels in Subjects With Chronic Periodontitis

Cited by 58 publications

References 26 publications

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Evaluation of Salivary Total Antioxidant Capacity in Smokers with Severe Chronic Periodontitis

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