Association of Chronic Periodontitis With Left Ventricular Mass and Central Blood Pressure in Treated Patients With Essential Hypertension

Franek, Edward; Klamczyńska, Ewa; Ganowicz, Ewa; Błach, Anna; Budlewski, Tadeusz; Górska, Renata

doi:10.1038/ajh.2008.330

Cited by 48 publications

(64 citation statements)

References 23 publications

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“…It is well known that SBP and PP in the aorta differ significantly from that recorded in the brachial artery [25]. Left ventricular mass and remodelling of the carotid artery are more closely related to central pressure rather than brachial pressure [26]. Indeed, patients with hypercholesterolaemia have a higher central PP and stiffer blood vessels than matched controls despite similar peripheral blood pressure [27].…”

Section: Discussionmentioning

confidence: 97%

Association of serum lipids with arterial stiffness in a population-based study in Beijing

Wang

Luo

et al. 2011

European Journal of Clinical Investigation

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Section: Discussionmentioning

confidence: 97%

Association of serum lipids with arterial stiffness in a population-based study in Beijing

Wang

Luo

et al. 2011

European Journal of Clinical Investigation

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“…9 Several studies measuring PWV in periodontitis patients with comorbidity (essential hypertension, type-2 diabetes mellitus or hypercholesterolaemia) reported no association between PWV and periodontitis. [10][11][12][13] To date, one periodontal intervention study has been conducted in patients diagnosed with severe essential refractory hypertension; the results show a positive effect of nonsurgical periodontal treatment on PWV after 6 months. 14 Taken together, it remains unclear if periodontitis is associated with PWV in a systemically healthy population, and whether periodontal intervention in otherwise healthy subjects can reduce PWV, thus decrease AS.…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness in periodontitis patients and controls

et al. 2015

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Increased arterial stiffness (AS) is an important indicator for atherosclerotic cardiovascular disease (ACVD). Epidemiologically, periodontitis and ACVD are associated. Therefore, we aimed to investigate AS in periodontitis patients and controls. In addition, we explored the effect of periodontal therapy on AS in a sub-group of cases. Pulse-wave velocity (PWV), a non-invasive chair-side function test for AS, was measured in periodontitis patients (n=57; mean age 46.6 years) and compared with a reference group (n=48; mean age 45.5 years). In addition, 45 cases (mean age 46.9 years) were 6 months followed after periodontal treatment, to explore a possible effect on arterial function. Periodontitis patients showed a significantly increased PWV compared with the reference group (8.01±0.20 vs. 7.36±0.22 m s(-1) respectively; P=0.029) and this remained significant after adjustments for ACVD risk factors (P=0.019). After periodontal therapy, no significant reduction in PWV was seen (8.00±1.8 to 7.82±1.6 m s(-1); P=0.13), but systolic blood pressure (SBP) was significantly reduced (119.8±14.6 to 116.9±15.1 mm Hg; P=0.040). It can be concluded that periodontitis is associated with increased AS. This confirms with a new parameter the association of periodontitis with ACVD. Although periodontal treatment did not lower AS significantly, a modest reduction of SBP after 6 months was observed.

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“…A number of potential risk indicators that could be associated with PD but are not proven to be causative have been identified, such as (i) increasing age, 12 (ii) specific periodontal pathogens such as Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum, 13,14 (iii) ethnic minorities, 15 (iv) low socio-economic status, 16 (v) male gender, 17,18 and (vi) stress. 19,20 Recent evidence suggests that common cardio-metabolic risk factors including body weight, 21,22 dyslipidaemia, 23 and hypertension 24 as individual components or clustered in the metabolic syndrome are also associated with increased odds of prevalence of periodontitis. 25 In terms of periodontitis-associated true risk factors (not including dental plaque accumulation), significant evidence exists on the role of cigarette smoking [26][27][28] and diabetes mellitus.…”

Section: Pathophysiologymentioning

confidence: 99%

European workshop in periodontal health and cardiovascular disease--scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature

Sanz

D’Aiuto

Deanfield

et al. 2010

European Heart Journal Supplements

145

122

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In the last 10 years, a rising number of epidemiological investigations have studied the possible association between chronic oral infections and cardiovascular diseases (CVD). These studies were based on the hypothesis that periodontal diseases (PD), may confer an independent risk for CVD. There is, however, still controversy whether these associations are causal or whether there are common aetiological factors common to both diseases (residual confounding). The objective of this paper was to review the possible association between PD and CVD on both the epidemiological association and the possible preventive and treatment implications.Although the reported epidemiological studies have shown a significant, albeit week associations, we still lack properly designed clinical trials demonstrating that these chronic infections are independent factors of cardiovascular risk. The use of surrogate variables assessing the infective load and measures of subclinical atherosclerosis have clearly shown, not only a significant pathogenic relationship, but also a significant impact after periodontal therapy.From a public health perspective, if further studies consistently identify PD as a risk factor for CHD and treatment studies show benefit, the implications are significant, since PD is mostly avoidable and treatable when not prevented. In addition, good preventive dental care has multiple other benefits, particularly on quality of life. Furthermore, identifying individuals at higher risk for CHD than predicted by traditional risk factors could facilitate treatment of risk factors known to decrease CHD events in high-risk individuals and this might be significant given the high prevalence of PD in the population and the common problem of CHD.

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Association of Chronic Periodontitis With Left Ventricular Mass and Central Blood Pressure in Treated Patients With Essential Hypertension

Abstract: More severe forms of periodontitis are associated with increased CBP and LVM in patients with primary hypertension.

Cited by 48 publications

References 23 publications

Association of serum lipids with arterial stiffness in a population-based study in Beijing

Association of serum lipids with arterial stiffness in a population-based study in Beijing

Arterial stiffness in periodontitis patients and controls

European workshop in periodontal health and cardiovascular disease--scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature

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