Association of Chronic Opisthorchis Infestation and Microbiota Alteration on Tumorigenesis in Cholangiocarcinoma

Ketpueak, Thanika; Thiennimitr, Parameth; Apaijai, Nattayaporn; Chattipakorn, Siriporn C.

doi:10.14309/ctg.0000000000000292

Cited by 10 publications

(12 citation statements)

References 69 publications

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“…Cholangiocarcinoma is an aggressive malignancy which presents late, is difficult to diagnose and is associated with high mortality [1] , [2] , [3] , [4] . It has an incidence of 1-2 per 100,000 in western countries, with a slightly higher incidence in Asia due to the presence of endemic parasites such as Opisthorcus viverrine and Clonorchis sinenis [ 2 , 4 ]. Cholangiocarcinoma arises from the epithelium of the hepatic bile ducts.…”

Section: Discussionmentioning

confidence: 99%

Solitary 18F-fluorodeoxyglucose avid spinous process cholangiocarcinoma metastasis proven on CT guided percutaneous needle bone biopsy.

Lee

Jiang

Kang

et al. 2021

Radiology Case Reports

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A 65-year-old female with newly diagnosed cholangiocarcinoma was referred for a FDG PET/CT for initial staging. There was a region of moderate FDG avidity localizing to the hepatic hilum representing the primary site of malignancy. An unexpected moderately FDG avid focus was demonstrated in the spinous process of the T11 vertebra with no corresponding mass lesion seen on low dose CT and no evidence of distant metastatic disease elsewhere. A percutaneous CT guided needle bone biopsy was performed which confirmed a solitary T11 spinous process metastasis on histopathology.

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Section: Discussionmentioning

confidence: 99%

Solitary 18F-fluorodeoxyglucose avid spinous process cholangiocarcinoma metastasis proven on CT guided percutaneous needle bone biopsy.

Lee

Jiang

Kang

et al. 2021

Radiology Case Reports

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“…The microbiota is a nonpathogenic microbial community living within the human body [64]. The interactions between the microbiota and the human host are important for host homeostasis [64][65][66].…”

Section: Microbiota and Biliary Tractmentioning

confidence: 99%

Any Role for Microbiota in Cholangiocarcinoma? A Comprehensive Review

Elvevi

Laffusa

Gallo

et al. 2023

Cells

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Alterations in the human microbiota have been linked to carcinogenesis in several cancers. To date, few studies have addressed the role of the microbiota in cholangiocarcinoma (CCA). Our work aims to update the knowledge about the role of the microbiota in the CCA microenvironment, and to highlight possible novel insights for the development of new diagnostic, prognostic, or even therapeutic strategies. We thus conducted a review of the literature. In recent years, great progress has been made in understanding the pathogenesis, the clinical and histological behavior, and the molecular profile of CCA. Much evidence suggests that the bile microbiota plays an essential role in biliary diseases, including CCA. Some studies have demonstrated that alterations in the qualitative and quantitative composition of the intestinal commensal bacteria lead to overall cancer susceptibility through various pathways. Other studies suggest that the gut microbiota plays a role in the pathogenesis and/or progression of CCA. The clinical implications are far-reaching, and the role of the microbiota in the CCA microenvironment may lead to considering the exciting implications of implementing therapeutic strategies that target the microbiota-immune system axis.

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“…In healthy people, the gut microbiota is ecologically balanced and meanwhile the link between gut microbiota and the pathogenesis of CCA is attracting more attention ( 104 , 105 ). Biliary obstruction caused by CCA leads to cholestasis, which provides a culture medium for bacteria.…”

Section: Microbiome and Ccamentioning

confidence: 99%

Utilizing Gut Microbiota to Improve Hepatobiliary Tumor Treatments: Recent Advances

Qin

Yuan²,

Huang³

et al. 2022

Front. Oncol.

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Hepatobiliary tumors, which include cholangiocarcinoma, hepatocellular carcinoma (HCC), and gallbladder cancer, are common cancers that have high morbidity and mortality rates and poor survival outcomes. In humans, the microbiota is comprised of symbiotic microbial cells (10-100 trillion) that belong to the bacterial ecosystem mainly residing in the gut. The gut microbiota is a complicated group that can largely be found in the intestine and has a dual role in cancer occurrence and progression. Previous research has focused on the crucial functions of the intestinal microflora as the main pathophysiological mechanism in HCC development. Intestinal bacteria produce a broad range of metabolites that exhibit a variety of pro- and anticarcinogenic effects on HCC. Therefore, probiotic alteration of the gut microflora could promote gut flora balance and help prevent the occurrence of HCC. Recent evidence from clinical and translational studies suggests that fecal microbiota transplant is one of the most successful therapies to correct intestinal bacterial imbalance. We review the literature describing the effects and mechanisms of the microbiome in the gut in the context of HCC, including gut bacterial metabolites, probiotics, antibiotics, and the transplantation of fecal microbiota, and discuss the potential influence of the microbiome environment on cholangiocarcinoma and gallbladder cancer. Our findings are expected to reveal therapeutic targets for the prevention of hepatobiliary tumors, and the development of clinical treatment strategies, by emphasizing the function of the gut microbiota.

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Association of Chronic Opisthorchis Infestation and Microbiota Alteration on Tumorigenesis in Cholangiocarcinoma

Cited by 10 publications

References 69 publications

Solitary 18F-fluorodeoxyglucose avid spinous process cholangiocarcinoma metastasis proven on CT guided percutaneous needle bone biopsy.

Solitary 18F-fluorodeoxyglucose avid spinous process cholangiocarcinoma metastasis proven on CT guided percutaneous needle bone biopsy.

Any Role for Microbiota in Cholangiocarcinoma? A Comprehensive Review

Utilizing Gut Microbiota to Improve Hepatobiliary Tumor Treatments: Recent Advances

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