Association of chronic central serous chorioretinopathy with subclinical Cushing's syndrome

Soares, Rebecca R.; Samuelson, Annika; Chiang, Allen

doi:10.1016/j.ajoc.2022.101455

Cited by 3 publications

(2 citation statements)

References 6 publications

(7 reference statements)

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“…This finding is also commonly found in a cause of acute painless vision disturbance in humans, central serous chorioretinopathy (CSCR) 26‐28 . Hypercortisolism is common in people with CSCR 29‐33 . Patients with CSCR have increased plasma fibrinogen concentration 34 and are at higher risk for thrombotic events.…”

Section: Discussionmentioning

confidence: 85%

“… 26 , 27 , 28 Hypercortisolism is common in people with CSCR. 29 , 30 , 31 , 32 , 33 Patients with CSCR have increased plasma fibrinogen concentration 34 and are at higher risk for thrombotic events. The proposed pathophysiology is that thrombosis limits choroidal perfusion, causing ischemic choroidal effusion and subsequent bullous retinal detachment.…”

Section: Discussionmentioning

confidence: 99%

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Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Lynch

Ruterbories

Robertson

et al. 2023

Veterinary Internal Medicne

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Background Sudden acquired retinal degeneration syndrome (SARDS) is a common cause of irreversible blindness in dogs. It bears clinical resemblance to hypercortisolism, which can be associated with hypercoagulability. The role of hypercoagulability in dogs with SARDS is unknown. Objective Determine hemostatic profiles in dogs with SARDS. Animals Prospective pilot study: Dogs with a history of SARDS (n = 12). Prospective case‐control study: Dogs with recent onset of SARDS (n = 7) and age‐, breed‐, and sex‐matched controls (n = 7). Methods Prospective pilot study: We performed thromboelastography (TEG). Prospective case‐control study: Dogs had CBC, serum biochemistry, urinalysis, TEG, fibrinogen concentration, antithrombin activity, D‐dimers, thrombin‐antithrombin complexes, and optical platelet aggregometry performed. Results Prospective pilot study: 9/12 dogs with a history of SARDS were hypercoagulable with increased TEG G value and 2/3 had hyperfibrinogenemia. Case‐control study: All dogs with SARDS and 5/7 controls were hypercoagulable based on TEG G value. Dogs with SARDS had significantly higher G values (median, 12.7 kdynes/s; range, 11.2‐25.4; P = .04) and plasma fibrinogen concentration (median, 463 mg/dL; range, 391‐680; P < .001) compared to controls. Conclusions and Clinical Importance Hypercoagulability was common in both dogs with SARDS and controls, but dogs with SARDS were significantly more hypercoagulable on TEG. The role of hypercoagulability in the pathogenesis of SARDS remains to be determined.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Lynch

Ruterbories

Robertson

et al. 2023

Veterinary Internal Medicne

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Impaired 11β-HSD1 Activity in a Male Patient With Cushing Disease Resulting in Lack of the Full Cushingoid Phenotype

Weber,

Kawaja,

Wallerstein

et al. 2024

JCEM Case Reports

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We present a patient who had surgically confirmed CD but without the full cushingoid phenotype despite markedly elevated cortisol. Nonpathologic causes of elevated ACTH and cortisol were eliminated as were pathogenic variants in the glucocorticoid receptor gene. Further studies of urine metabolites, cortisol half-life, and the ratios of cortisone to cortisol conversion revealed impaired 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity. There have only been 2 prior reports of impaired 11β-HSD1 resulting in lack of classic cushingoid features in the past 2 decades. Our patient's presentation and previous reports demonstrate the key role of 11β-HSD1 in modulating intracellular cortisol concentration, therefore shielding the peripheral tissues from the effects of excess cortisol. When patients present with markedly elevated cortisol but without classic cushingoid features, impaired 11β-HSD1 should be considered in the differential diagnosis.

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OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy

et al. 2023

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Similar to ultrasound adapting soundwaves to depict the inner structures and tissues, optical coherence tomography (OCT) utilizes low coherence light waves to assess characteristics in the eye. Compared to the previous gold standard diagnostic imaging fluorescein angiography, OCT is a noninvasive imaging modality that generates images of ocular tissues at a rapid speed. Two commonly used iterations of OCT include spectral-domain (SD) and swept-source (SS). Each comes with different wavelengths and tissue penetration capacities. OCT angiography (OCTA) is a functional extension of the OCT. It generates a large number of pixels to capture the tissue and underlying blood flow. This allows OCTA to measure ischemia and demarcation of the vasculature in a wide range of conditions. This review focused on the study of four commonly encountered diseases involving the retina including age-related macular degeneration (AMD), diabetic retinopathy (DR), central serous chorioretinopathy (CSC), and macular telangiectasia (MacTel). Modern imaging techniques including SD-OCT, TD-OCT, SS-OCT, and OCTA assist with understanding the disease pathogenesis and natural history of disease progression, in addition to routine diagnosis and management in the clinical setting. Finally, this review compares each imaging technique’s limitations and potential refinements.

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Association of chronic central serous chorioretinopathy with subclinical Cushing's syndrome

Cited by 3 publications

References 6 publications

Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Impaired 11β-HSD1 Activity in a Male Patient With Cushing Disease Resulting in Lack of the Full Cushingoid Phenotype

OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy

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