Association of chromosomal locus 8q24 and risk of prostate cancer: A hospital-based study of German patients treated with brachytherapy

Meyer, Andreas; Schürmann, Peter; Ghahremani, Maryam; Kocak, Ertan; Brinkhaus, Maria-Jantje; Bremer, Michael; Karstens, Johann H.; Hagemann, Jörn; Machtens, S.; Dörk, Thilo

doi:10.1016/j.urolonc.2008.04.010

Cited by 13 publications

(5 citation statements)

References 20 publications

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“…We noted that chromosome 8 seemed to be very frequently involved (5 of 7 events) in genomic rearrangements in HCC1954. In particular, 8q24 seemed a recombination hot spot (4 break events), which coincides with the findings that polymorphic loci at 8q24 are risk factors for breast and prostate cancer from genome wide studies (14,15).…”

Section: Resultssupporting

confidence: 85%

Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line

Zhao

Caballero

Lévy

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

107

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We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able to identify genomic rearrangement events leading to fusions or truncations of genes including MRE11 and NSD1, genes already implicated in oncogenesis, and 7 rearrangements involving other additional genes. This approach demonstrates that high-throughput transcriptome sequencing is an effective strategy for the characterization of genomic rearrangements in cancers.cancer genome ͉ transcriptome sequencing

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Section: Resultssupporting

confidence: 85%

Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line

Zhao

Caballero

Lévy

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

107

View full text Add to dashboard Cite

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“…Shortly after these findings, additional studies led to the uncovering of other 8q24 regions of risk [9,10] and also confirmation and replication in additional diverse populations [9,[11][12][13][14]. Another GWAS found an association with increased risk of prostate cancer in regions 17q12 and 17q24 [15] which, similar to the aforementioned 8q studies, lead to confirmation and replication in additional populations [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 73%

Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans

et al. 2009

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“…General sample of all populations the Netherlands [28] European community [29] Германия [30] Australia [31] Great Britain [23] Sweden [3] Iceland [3] 0. …”

Section: General Sample Of African American Populationsmentioning

confidence: 99%

Association of chromosome 8q24 variants with prostate cancer risk in the Siberian region of Russia and meta-analysis

et al. 2012

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Compelling evidence demonstrates the importance of chromosome 8q24 as a locus of susceptibil ity to prostate cancer. In this work, the association of common 8q24 variants, rs6983267 and rs1447295, with a sporadic risk of prostate cancer was analyzed in the Russian population of Siberia. For this purpose, the above polymorphisms were genotyped in 393 cases and 384 control individuals. The A allele of rs1447295 was significantly associated with prostate cancer risk (OR[CI 95%] = 1.74 [1.26-2.4], p = 7.8 × 10 -4 ). The com mon G-A haplotype of rs6983267-rs1447295 also showed association with prostate cancer risk in Russians (OR[CI 95%] = 2.03 [1.1-3.75], p = 0.02). A meta analysis combining our data with previously published results was performed to better evaluate the association between the SNPs studied and prostate cancer risk; its results strongly supported the association for both loci (p < 10 -6 ). Thus, our study has confirmed the asso ciation of chromosome 8q24 with a risk of prostate cancer.

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Association of chromosomal locus 8q24 and risk of prostate cancer: A hospital-based study of German patients treated with brachytherapy

Cited by 13 publications

References 20 publications

Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line

Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line

Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans

Association of chromosome 8q24 variants with prostate cancer risk in the Siberian region of Russia and meta-analysis

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