Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes

Shen, Zhijun; Yang, Xiufen; Xu, Jun; She, Chongyang; Wei, Wuran; Zhu, Wan-Lu; Liu, Ningpu

doi:10.18240/ijo.2017.04.18

Cited by 16 publications

(23 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 39 Regatieri et al, 10 however, reported a thinner CT in patients with diabetic macular edema or treated proliferative DR compared with normal subjects. Vujosevic et al, 11 Esmaeelpour et al, 12 , 13 Querques et al 14 and Shen et al 15 also demonstrated that CT decreases in diabetic eyes with clinical signs of DR compared with controls.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Benfica¹,

Zanella²,

Farias³

et al. 2018

OPTH

View full text Add to dashboard Cite

PurposeTo analyze choroidal thickness (CT) of pregnant women with type 1 diabetes mellitus (DM), type 2 DM and gestational diabetes mellitus (GDM) using spectral-domain optical coherence tomography.Patients and methodsThis cross-sectional study included 144 eyes of 72 pregnant women in the third trimester divided into four groups: 27 non-diabetic pregnant women; 15 pregnant women with GDM; 16 with type 2 DM and 14 with type 1 DM. CT was measured using optical coherence tomography at ten different locations. We also analyzed possible confounding factors, such as gestational age, glycosylated hemoglobin, time from DM diagnosis, hypertension and severity of diabetic retinopathy.ResultsThe comparison between the four groups showed a thinner choroid in patients with type 1 DM in all locations, with statistical significance in subfoveal and temporal measurements. When comparing only patients with type 1 and type 2 DM, adjusting for confounding factors, the choroid of patients with type 1 DM remained thinner at all macular points, also with statistical significance in subfoveal and temporal measurements.ConclusionPregnant women with type 1 DM had significantly thinner CT measurements on subfoveal and temporal locations. No differences were found in CT between the control group and pregnant women with GDM and type 2 DM.

show abstract

Section: Discussionmentioning

confidence: 94%

“… 9 EDI-OCT dramatically increases image resolution of the choroid by decreasing signal strength posterior to the retinal pigment epithelium. Although many authors have reported a decrease in choroidal thickness (CT) among diabetic patients, 10 – 15 there are some discordant studies. 7 , 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Benfica¹,

Zanella²,

Farias³

et al. 2018

OPTH

View full text Add to dashboard Cite

show abstract

“…Choroidal changes in diabetic patients might play an important role in the development of DR, because the choroid is responsible for supplying blood to the outer retinal layer 10 . Several choroidal changes have been described in diabetic patients, but reports on CT in such eyes are discrepant.…”

Section: Discussionmentioning

confidence: 99%

“…Several choroidal alterations in diabetic patients have been described in the literature 10 – 14 . Recently there has been a focus on CT, which differs significantly from that of healthy patients; however, inconsistent results have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Recently there has been a focus on CT, which differs significantly from that of healthy patients; however, inconsistent results have been reported. Several investigators have reported that CT was significantly reduced in mild or moderate non-proliferative DR (NPDR) 10 , 14 . Conversely, others reported that subfoveal CT (SFCT) increased as DR worsened to proliferative DR (PDR), and decreased in diabetic macular edema (DME) or laser-treated eyes 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography

Kim

Choi

et al. 2018

Sci Rep

127

125

View full text Add to dashboard Cite

The relationships between changes in choroidal vasculature and the severity of diabetic retinopathy (DR) remain unclear. We assessed choroidal changes in diabetic patients by measuring choroidal vascularity index (CVI) in conjunction with DR stage. In this study, patients with diabetes and healthy controls were retrospectively analyzed. Subjects were divided into seven groups as follows: Healthy controls, no DR, mild/moderate non-proliferative DR (NPDR), severe NPDR, proliferative DR (PDR), panretinal photocoagulation-treated DR, and clinically significant macular edema. The mean CVI values in the above groups were 69.08, 67.07, 66.28, 66.20, 63.48, 65.38, and 66.28, respectively. The eyes of diabetic patients exhibited a significantly lower CVI value than those of healthy controls even without DR. The PDR group exhibited a significantly lower CVI value than the healthy control, no DR, and mild/moderate NPDR groups. Age, sex, disease duration, glycated hemoglobin, fasting blood sugar, or intraocular pressure had no correlation with CVI. In multivariate regression analysis, thicker subfoveal choroid and thinner central retina were significantly associated with higher CVI values. These findings carefully suggest that changes in choroidal vasculature could be the primary event in diabetes even where there is no DR.

show abstract

Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions

et al. 2019

View full text Add to dashboard Cite

Aging of the microcirculatory network plays a central role in the pathogenesis of a wide range of agerelated diseases, from heart failure to Alzheimer's disease. In the eye, changes in the choroid and choroidal microcirculation (choriocapillaris) also occur with age, and these changes can play a critical role in the pathogenesis of age-related macular degeneration (AMD). In order to develop novel treatments for amelioration of choriocapillaris aging and prevention of AMD, it is essential to understand the cellular and functional changes that occur in the choroid and choriocapillaris during aging. In this review, recent advances in in vivo analysis of choroidal structure and function in AMD patients and patients at risk for AMD are discussed. The pathophysiological roles of fundamental cellular and molecular mechanisms of aging including oxidative GeroScience

show abstract

Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes

Abstract: CT decreased significantly in the NDR and mild/moderate NPDR eyes compared with the control eyes. Age is significantly associated with SFCT in the diabetic patients. Diabetic choroidopathy may be present before clinical retinopathy.

Cited by 16 publications

References 27 publications

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography

Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions

Contact Info

Product

Resources

About