Association of cholesteryl ester transfer protein −629C &gt; A polymorphism with high‐density lipoprotein cholesterol levels in coronary artery disease patients

Tanrikulu, Sevda; Ademoğlu, Evin; Gürdöl, Figen; Mutlu-Türkoglu, Ü.; Bilge, Ahmet Kaya; Nişancí, Yílmaz

doi:10.1002/cbf.1593

Cited by 5 publications

(9 citation statements)

References 26 publications

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“…Both Taq1B and -629C > A polymorphisms could possibly have independent effects on HDL-C and apoA1 levels and hence they do not show significant effects individually when they are included in the same 2-way ANCOVA model. In the Turkish population, it was found that CETP - 629C > A polymorphism was not associated with CAD [43]. As with any complex traits, the genotypic effect is usually confounded by environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population

Tayebi

et al. 2013

Lipids Health Dis

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BackgroundHyperlipidaemia is a major risk factor for coronary artery disease (CAD) and cholesteryl ester transfer protein (CETP) gene polymorphisms are known to be associated with lipid profiles.MethodsIn this study, we investigated the association of two polymorphisms in the CETP, Taq1B (rs708272) and -629C > A (rs1800775), with CAD and lipid levels HDL-C in 662 CAD + cases and 927 controls from the Singapore population comprising Chinese, Malays and Indians.ResultsTaqB2 frequency was significantly lowest in the Malays (0.43) followed by Chinese (0.47) and highest in the Indians (0.56) in the controls. The B2 allele frequency was significantly lower in the Chinese CAD + cases compared to the controls (p = 0.002). The absence of the B2 allele was associated with CAD with an OR 2.0 (95% CI 1.2 to 3.4) after adjustment for the confounding effects of age, smoking, BMI, gender, hypertension, dyslipidemia and diabetes mellitus. The B2 allele was significantly associated with higher plasma HDL-C levels in the Chinese men after adjusting for confounders. Associations with plasma apoA1 levels were significant only in the Chinese men for Taq1B and -629C > A. In addition, the Taq1B polymorphism was only associated with plasma Apo B and Lp(a) in the Malay men. Significant associations were only found in non-smoking subjects with BMI <50th percentile. In this study, the LD coefficients between the Taq1B and -629C > A polymorphisms seemed to be weak.ConclusionThe absence the Taq1B2 allele was associated with CAD in the Chinese population only and the minor allele of the Taq1B polymorphism of the CETP gene was significantly associated with higher plasma HDL-C levels in Chinese men.

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Section: Discussionmentioning

confidence: 99%

Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population

Tayebi

et al. 2013

Lipids Health Dis

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“…CETP concentration is associated with the common Taq 1B polymorphism, and carriers of the B2 allele exhibit lower plasma CETP levels, higher HDL and reduced risk for coronary heart disease (Boekholdt et al, 2005;Thompson et al, 2008;Van Acker et al, 2008). However, other studies of different CETP polymorphisms, such as -629 C>A and Taq IB, did not support this association (Lu et al, 2003;Tanrikulu et al, 2009). Overall, the influence of CETP on the anti-atherogenic properties of HDL in vivo must be investigated.…”

Section: Discussionmentioning

confidence: 90%

Association between diet and polymorphisms in individuals with statin-controlled dyslipidaemia grouped according to oxidative stress biomarkers

Botelho

Fioratti

Rogero

et al. 2012

Braz. J. Pharm. Sci.

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The objective of this study was to investigate whether differences in diet and in single-nucleotide polymorphisms (SNPs) found in paraoxonase-1 (PON-1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), cholesterol ester transfer protein (CETP) and apolipoprotein E (APOE) genes, are associated with oxidative stress biomarkers and consequently with susceptibility of low-density cholesterol (LDL) to oxidation. A multivariate approach was applied to a group of 55 patients according to three biomarkers: plasma antioxidant activity, malondialdehyde and oxidized LDL (oxLDL) concentrations. Individuals classified in Cluster III showed the worst prognoses in terms of antioxidant activity and oxidative status. Individuals classified in Cluster I presented the lowest oxidative status, while individuals grouped in Cluster II presented the highest levels of antioxidant activity. No difference in nutrient intake was observed among the clusters. Significantly higher γ-and δ-tocopherol concentrations were observed in those individuals with the highest levels of antioxidant activity. No single linear regression was statistically significant, suggesting that mutant alleles of the SNPs selected did not contribute to the differences observed in oxidative stress response. Although not statistically significant, the p value of the APO E coefficient for oxLDL response was 0.096, indicating that patients who carry the TT allele of the APO E gene tend to present lower plasma oxLDL concentrations. Therefore, the differences in oxidative stress levels observed in this study could not be attributed to diet or to the variant alleles of PON-1, CETP, HMGCR or APO E. This data supports the influence of γ-tocopherol and δ-tocopherol on antioxidant activity, and highlights the need for further studies investigating APO E alleles and LDL oxidation.Uniterms: Diet. Oxidative stress/biomarkers. Single-nucleotide polymorphism (SNPs). Lipoproteins/ oxidation. Statins. Apolipoprotein E.O objetivo deste estudo foi investigar se diferenças na dieta e em polimorfismos de nucleotídeos únicos (SNPs) encontrados no gene da paraoxonase 1 (PON-1), da 3-hidroxi-3-metilglutaril-coenzima A reductase (HMGCR), da proteína de transferência de ésteres de colesterol (CETP) e da apolipoproteina E (APOE) estariam associadas com biomarcadores do estresse oxidativo e, consequentemente, com a suscetibilidade da LDL à oxidação. Técnicas da estatística multivariada foram aplicadas a um grupo de 55 pacientes usando 3 biomarcadores: atividade antioxidante plasmática, concentrações de malondialdeído e LDL oxidada. Indivíduos classificados no cluster III apresentaram um prognóstico negativo em termos de atividade antioxidante e estado oxidativo. Os indivíduos agrupados no cluster I apresentaram o mais baixo nível de estado oxidativo, enquanto que indivíduos no cluster II apresentaram os mais altos níveis de atividade antioxidante. Nenhuma diferença na ingestão de nutrientes foi observada entre os clusters.Concentrações estatísticamente mais altas de γ-e δ-tocoferol foram...

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“…Among these eligible studies, 33 involved the relationship between CETP rs708272 polymorphisms and CAD ( 15 – 47 ). Other 37 studied five other polymorphisms in the CETP gene, and 14 of them focused on rs5882 ( 15 , 22 , 26 , 29 , 31 , 32 , 35 , 44 , 46 , 50 , 53 , 55 , 59 , 60 ), 11 on rs1800775 ( 26 , 27 , 31 , 32 , 35 , 44 , 52 , 57 – 60 )3 on rs4783961 ( 16 , 35 , 51 ), 3 on rs247616 ( 19 , 48 , 56 ), 2 on rs5883 ( 49 , 54 ), 2 on rs1800776 ( 44 , 60 ), and 2 on rs1532624 ( 19 , 26 ). In addition, 6 studies deviated from HWE ( 19 , 30 , 32 , 39 , 41 , 46 ).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-one articles mentioned studies performed among Caucasians ( 15 , 16 , 18 , 19 , 21 – 25 , 28 – 30 , 33 – 35 , 37 – 44 , 48 – 50 , 53 , 57 , 58 , 60 ), and 15 among Asians ( 17 , 20 , 26 , 27 , 31 , 32 , 36 , 45 , 46 , 51 , 52 , 54 – 56 , 59 ).…”

Section: Resultsmentioning

confidence: 99%

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Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis

Zhang,

Xie,

Xiao

2023

Front. Cardiovasc. Med.

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AimsThis meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein (CETP) rs708272 (G>A), rs5882 (G>A), rs1800775 (C>A), rs4783961 (G>A), rs247616 (C>T), rs5883 (C>T), rs1800776 (C>A), and rs1532624 (C>A) with coronary artery disease (CAD) and the related underlying mechanisms.MethodsA comprehensive search was performed using five databases such as PubMed, EMBASE, Web of Science, Cochrane Library and Scopus to obtain the appropriate articles. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The statistical analysis of the data was performed using STATA 17.0 software. The association between CETP gene polymorphisms and risk of CAD was estimated using the pooled odds ratio (OR) and 95% confidence interval (95% CI). The association of CETP gene polymorphisms with lipids and with CETP levels was assessed using the pooled standardized mean difference and corresponding 95% CI. P < 0.05 was considered statistically significant.ResultsA total of 70 case-control studies with 30,619 cases and 31,836 controls from 46 articles were included. The results showed the CETP rs708272 polymorphism was significantly associated with a reduced risk of CAD under the allele model (OR = 0.846, P < 0.001), the dominant model (OR = 0.838, P < 0.001) and the recessive model (OR = 0.758, P < 0.001). AA genotype and GA genotype corresponded to higher high-density lipoprotein cholesterol (HDL-C) concentrations in the blood compared with GG genotype across the studied groups (all P < 0.05). The CETP rs5882 and rs1800775 polymorphisms were not significantly associated with CAD under the allele model (P = 0.802, P = 0.392), the dominant model (P = 0.556, P = 0.183) and the recessive model (P = 0.429, P = 0.551). Similarly, the other mentioned gene polymorphisms were not significantly associated with CAD under the three genetic models.ConclusionsThe CETP rs708272 polymorphism shows a significant association with CAD, and the carriers of the allele A are associated with a lower risk of CAD and higher HDL-C concentrations in the blood compared to the non-carriers. The CETP rs5882, rs1800775, rs4783961, rs247616, rs5883, rs1800776, and rs1532624 are not significantly associated with CAD.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432865, identifier: CRD42023432865.

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Association of cholesteryl ester transfer protein −629C > A polymorphism with high‐density lipoprotein cholesterol levels in coronary artery disease patients

Cited by 5 publications

References 26 publications

Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population

Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population

Association between diet and polymorphisms in individuals with statin-controlled dyslipidaemia grouped according to oxidative stress biomarkers

Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis

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