Association of Cholesterol Ester Transfer Protein Taq IB Polymorphism With Acute Coronary Syndrome in Egyptian National Patients

Maksoud, Sahar M. Abdel; El-Garf, Wael; Ali, Ola; Shaaban, Gamal; Amer, Noha

doi:10.1093/labmed/lmw071

Cited by 4 publications

(9 citation statements)

References 33 publications

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“…In recent years, a lot of clinical studies had explored the relationship between rs708272 polymorphism and the risk of cardiovascular disease and lipid levels. [25,26] But the results were inconsistent in different countries. Even in the same country, the results were also controversial.…”

Section: Discussionmentioning

confidence: 99%

“…[20] In 2017, Abdel Maksoud et al found that CETP rs708272 polymorphism decreased the risk of unstable angina in Egyptian national patients. [26] Vargas-Alarcon et al revealed that this variant was not only associated with the risk of acute coronary syndrome but also with HDL-C levels and HDL subclasses in Mexican mestizos. [27] However, a prospective population-based study conducted in Caucasians demonstrated that CETP rs708272 was associated with increased levels of HDL-C, but not a decreased risk for CAD.…”

Section: Discussionmentioning

confidence: 99%

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Gender specific effect of CETP rs708272 polymorphism on lipid and atherogenic index of plasma levels but not on the risk of coronary artery disease

2018

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gender specific effect of CETP rs708272 polymorphism on lipid and atherogenic index of plasma levels but not on the risk of coronary artery disease

2018

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“…In addition, 6 studies deviated from HWE ( 19 , 30 , 32 , 39 , 41 , 46 ). Among all 46 articles, 10 mentioned information on lipid serum concentrations including HDL-C, LDL-C, TG and TC for rs708272 ( 19 – 21 , 23 , 25 , 26 , 30 , 31 , 38 , 44 ). One article was on the association between CETP rs708272 polymorphism and CETP level ( 23 ).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-one articles mentioned studies performed among Caucasians ( 15 , 16 , 18 , 19 , 21 – 25 , 28 – 30 , 33 – 35 , 37 – 44 , 48 – 50 , 53 , 57 , 58 , 60 ), and 15 among Asians ( 17 , 20 , 26 , 27 , 31 , 32 , 36 , 45 , 46 , 51 , 52 , 54 – 56 , 59 ).…”

Section: Resultsmentioning

confidence: 99%

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Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis

Zhang,

Xie,

Xiao

2023

Front. Cardiovasc. Med.

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AimsThis meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein (CETP) rs708272 (G>A), rs5882 (G>A), rs1800775 (C>A), rs4783961 (G>A), rs247616 (C>T), rs5883 (C>T), rs1800776 (C>A), and rs1532624 (C>A) with coronary artery disease (CAD) and the related underlying mechanisms.MethodsA comprehensive search was performed using five databases such as PubMed, EMBASE, Web of Science, Cochrane Library and Scopus to obtain the appropriate articles. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The statistical analysis of the data was performed using STATA 17.0 software. The association between CETP gene polymorphisms and risk of CAD was estimated using the pooled odds ratio (OR) and 95% confidence interval (95% CI). The association of CETP gene polymorphisms with lipids and with CETP levels was assessed using the pooled standardized mean difference and corresponding 95% CI. P < 0.05 was considered statistically significant.ResultsA total of 70 case-control studies with 30,619 cases and 31,836 controls from 46 articles were included. The results showed the CETP rs708272 polymorphism was significantly associated with a reduced risk of CAD under the allele model (OR = 0.846, P < 0.001), the dominant model (OR = 0.838, P < 0.001) and the recessive model (OR = 0.758, P < 0.001). AA genotype and GA genotype corresponded to higher high-density lipoprotein cholesterol (HDL-C) concentrations in the blood compared with GG genotype across the studied groups (all P < 0.05). The CETP rs5882 and rs1800775 polymorphisms were not significantly associated with CAD under the allele model (P = 0.802, P = 0.392), the dominant model (P = 0.556, P = 0.183) and the recessive model (P = 0.429, P = 0.551). Similarly, the other mentioned gene polymorphisms were not significantly associated with CAD under the three genetic models.ConclusionsThe CETP rs708272 polymorphism shows a significant association with CAD, and the carriers of the allele A are associated with a lower risk of CAD and higher HDL-C concentrations in the blood compared to the non-carriers. The CETP rs5882, rs1800775, rs4783961, rs247616, rs5883, rs1800776, and rs1532624 are not significantly associated with CAD.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432865, identifier: CRD42023432865.

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Association of Serum Cholesterol Ester Transfer Protein Levels with Taq IB Polymorphism in Acute Coronary Syndrome

Amer

Shaaban

2019

Laboratory Medicine

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Information on the relationship between circulating cholesteryl ester transfer protein (CETP) levels and coronary heart disease (CHD) incidence (and also, therefore, acute coronary syndrome [ACS]) is conflicting. Many studies have been published concerning this relationship, most of which have incompatible results. In our study, we aimed to determine serum CETP levels in subject individuals with ACS and healthy control individuals, and the association of those levels with Taq IB polymorphism. The current study was conducted with 62 hospitalized patients who had been diagnosed with ACS and 26 controls. All subjects were selected from a previous study of which we are among the coauthors. Serum CETP levels were determined by quantitative enzyme-linked immunosorbent assay (ELISA). The mean serum CETP levels in all patients were significantly higher than those in controls. CETP TaqIB polymorphism affected serum CETP levels, with higher serum CETP for the GA genotype in both groups than in other genotypes. Although the AA genotype showed higher CETP levels than the GG genotype in patients with ACS, the GG showed higher CETP than the AA in healthy controls. Our results support an association between high serum CETP and ACS incidence. Our study helped address some of the controversies regarding the relationship of serum CETP mass to atherosclerosis, in addition to the association of ACS occurrence with circulating CETP levels.

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Association of Cholesterol Ester Transfer Protein Taq IB Polymorphism With Acute Coronary Syndrome in Egyptian National Patients

Cited by 4 publications

References 33 publications

Gender specific effect of CETP rs708272 polymorphism on lipid and atherogenic index of plasma levels but not on the risk of coronary artery disease

Gender specific effect of CETP rs708272 polymorphism on lipid and atherogenic index of plasma levels but not on the risk of coronary artery disease

Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis

Association of Serum Cholesterol Ester Transfer Protein Levels with Taq IB Polymorphism in Acute Coronary Syndrome

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