Association of Chlamydia trachomatis Infection With Redetection of Human Papillomavirus After Apparent Clearance

Shew, Marcia L.; Ermel, Aaron; Weaver, Bree; Tong, Yan; Tu, Wanzhu; Kester, Laura M.; Denski, Cheryl; Fortenberry, J.Dennis; Brown, Darron R.

doi:10.1093/infdis/jit346

Cited by 26 publications

(23 citation statements)

References 27 publications

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“…This discrepancy could be due to the more sensitive detection technique employed in our study (Comar et al, 2012) and to the adoption of a different method to calculate prevalence, using the number of women infected with C. trachomatis as the denominator. Our results seem to confirm a role for C. trachomatis in enhancing susceptibility to multiple HPVs or in type-specific HPV redetection, as a result of the reactivation of low-level persistent HPV (Shew et al, 2013).…”

Section: Discussionsupporting

confidence: 68%

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

Seraceni

Campisciano

Contini

et al. 2016

Journal of Medical Microbiology

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Human papillomavirus (HPV) and Chlamydia trachomatis are pathogens with oncogenic potential associated with persistent infections. Epidemiological data on C. trachomatis infection status, C. trachomatis/HPV co-infection and the relationship between HPV genotypes in Italian women are only preliminary. The aim of the present study was to characterize the relationship between HPV genotypes and C. trachomatis in an extending cohort of asymptomatic immunocompetent women from an area of north-east Italy. A retrospective study was conducted using Luminex technology on cervical swabs from asymptomatic immunocompetent women, comprising 921 attending the prevention centre for the Cervical Cancer Program and 6214 who had been referred to the Sexually Transmitted Infections Center, with clinical indications of HPV and C. trachomatis infections. A quantitative real-time PCR was performed to assess chronic C. trachomatis infection by heat-shock protein 60 (Hsp60) gene expression. The overall prevalence of the investigated pathogens was 39 % (359/921) for HPV and 4 % (251/6214) for C. trachomatis. The Hsp60 gene was detected in 57 % of the women infected with C. trachomatis. HPV co-infection was present in 58 % of C. trachomatis-infected women. A high prevalence of co-infection was found in women with chronic C. trachomatis infection (68 %, P50.0002), especially in women j25 years (72 %) where HPV multiple infections were found in 78 % (P50.022). HPV genotype distribution showed that uncommon low-risk genotypes were associated with C. trachomatis. These results indicate a high frequency of co-detection of multiple HPV genotypes in chronically infected young women and suggest that the expression of the C. trachomatis Hsp60 gene may favour HPV infection.

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Section: Discussionsupporting

confidence: 68%

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

Seraceni

Campisciano

Contini

et al. 2016

Journal of Medical Microbiology

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“…Prior studies have investigated the role of microorganisms like Ct that cause a chronic inflammation as a potential risk factor in the transmission and persistence of HPV, as well as contributing to the progression of cervical carcinogenesis [11, 12]. Our study population had a 15.6% frequency of Ct infection, as assessed by analysis of the liquid preservative media utilized for cervical cancer screening.…”

Section: Discussionmentioning

confidence: 99%

“…In the United States screening programs for Ct are available for women aged 25 years or younger, and for women at risk for this infection. Increased testing and treatment may explain the overall lower prevalence, as well as the lower rate found among women aged 25 years and older in the United States as compared to Brazil [12]. …”

Section: Discussionmentioning

confidence: 99%

Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/Ki-67 dual-staining

Robial

Longatto‐Filho

Roteli-Martins

et al. 2017

Infect Agents Cancer

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Background Chlamydia trachomatis (Ct) is not a disease subject to mandatory reporting in Brazil, and the prevalence rate of this genital infection varies according to the region in which studies are conducted, as well as by the detection technique employed. Ct has been associated with persistence of Human papillomavirus (HPV) infection and the facilitation of cervical carcinoma development. We evaluated the Chlamydia trachomatis infection and its association with cytology, p16/Ki-67 dual-stained cytology and cervical intraepithelial lesions status in a screening cohort in Brazil.MethodsThis was a cross-sectional study of 1481 cervical samples from asymptomatic women aged 18 to 64. Samples were collected for liquid-based cytology and Ct detection by polymerase chain reaction. p16/Ki-67 double staining was performed on samples with abnormal cytology. Statistical analysis was by chi-square and likelihood-ratio tests. Odds ratio (OR) and 95% confidence intervals (95% CI) were determined.ResultsThe frequency of Ct was 15.6% and its presence was not associated with detection of p16/Ki-67 [OR = 1.35 (0.5–3.4)]. There was also no association between abnormal cervical cytology and Ct-positivity [OR = 1.21 (0.46–3.2)]. Associations were observed between p16/Ki-67 and high-grade lesions detected by cytology and in biopsies [OR = 3.55 (1.50–8.42) and OR = 19.00 (0.6–7.2), respectively].ConclusionsThe asymptomatic women in our study had a high frequency of Ct infection but this was not associated with p16/Ki-67 detection in samples with abnormal cytology. The expression of p16/Ki-67 was highest in women with high-grade CIN (p = 0.003).

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“…Potential risk factors for HPV persistence that were determined previously in various studies are age, age at first intercourse, number of sex partners (lifetime and recent), smoking, contraception methods, chlamydia and herpes simplex virus infection, chronic inflammation, immunosuppressive conditions, and menopause (34)(35)(36)(37)(38)(39)(40)(41)(42)(43). Results from these studies, however, were inconsistent partly because different populations had been studied.…”

Section: Discussionmentioning

confidence: 99%

Elevated Expression of Human Papillomavirus-16/18 E6 Oncoprotein Associates with Persistence of Viral Infection: A 3-Year Prospective Study in China

Kang

Zhao

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: An association between high-risk human papillomavirus (HR-HPV) oncoprotein expression and viral persistence has been suggested by the outcome of etiology studies, but there are no epidemiologic studies evaluating that link.Methods: We performed a 3-year prospective study in which 2,498 Chinese women ages 25 to 65 years were screened by six screening tests, including the OncoE6 Cervical Test (Arbor Vita Corporation) in 2011 (baseline). Six-hundred and ninety women who were positive for any of the tests and a random sample of 164 women with all negative results received colposcopy, and cervical specimens for the cobas 4800 HPV test ("cobas," Roche Molecular Systems) were collected before colposcopy; of this group, 737 cervical specimens were collected to perform cobas and OncoE6 Cervical Test in 2014 (follow-up). Twenty-four cases of HPV16/18 E6 positives and 204 selected controls at baseline, 13 cases of

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Association of Chlamydia trachomatis Infection With Redetection of Human Papillomavirus After Apparent Clearance

Cited by 26 publications

References 27 publications

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/Ki-67 dual-staining

Elevated Expression of Human Papillomavirus-16/18 E6 Oncoprotein Associates with Persistence of Viral Infection: A 3-Year Prospective Study in China

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