Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism

Mou, Xin; Liu, Wenhong; Zhou, Danyang; Liu, Yinghui; Hu, Yongbin; Ma, Guo-ling; Shou, Chengchao; Chen, Jiawei; Zhao, Jinxi

doi:10.1007/s11655-011-0845-5

Cited by 14 publications

(12 citation statements)

References 6 publications

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“…Only a significantly increased frequency of the C allele and CC genotype of the T869C polymorphism was observed in patients with nephropathy, suggesting the association of this polymorphism with an increased risk of T2D renal complication. Similar results were observed by Mou et al [38] that investigated the T869C polymorphism in 180 T2D Chinese patients with nephropathy in stages III, IV, and V, besides 180 patients without this complication. They also reported that CC/CT genotypes were associated with an increased risk of worsening renal function.…”

Section: Tgf-1 Gene Polymorphisms and Diabetic Nephropathysupporting

confidence: 87%

The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy

Gomes

Rodrigues

Fernandes

2014

International Journal of Medical Genetics

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Several studies have demonstrated that chronic and low-grade inflammation is closely linked to type 2 diabetes mellitus. The associated mechanisms are related to synthesis and release of proinflammatory and anti-inflammatory cytokines, mainly by the adipose tissue. Moreover, there are evidences that cytokines and adhesion molecules are important for development of diabetic nephropathy. Among the cytokines associated with inflammatory responses in type 2 diabetes mellitus, the transforming growth factor-β(TGF-β) has been recognized as a central player in the diabetic nephropathy being involved in the development of glomerulosclerosis and interstitial fibrosis, as observed in the course of end-stage renal disease. Although TGF-β1 is classically an anti-inflammatory immune mediator it has been shown that in the presence of IL-6, which increases before the onset of T2D, TGF-β1 favors the differentiation of T helper 17 (Th17) cells that are activated in many pro-inflammatory conditions. Since TGF-β1 mRNA and consequently serum TGF-β1 levels are under genetic control, this review aims to discuss the relationship of TGF-β1 levels and polymorphisms in the development of nephropathy in type 2 diabetes mellitus.

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Section: Tgf-1 Gene Polymorphisms and Diabetic Nephropathysupporting

confidence: 87%

The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy

Gomes

Rodrigues

Fernandes

2014

International Journal of Medical Genetics

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“…Eight studies [ 12 , 32 , 69 – 74 ] reporting the association of the TGF-β1 T869C gene polymorphism with susceptibility to T2DN were included in this study. Two report [ 69 , 74 ] were published using the English language and the other reports were published using Chinese. The data for the pooled OR were extracted (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population

Zhou

Zhong

et al. 2018

BMC Med Genet

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BackgroundDiabetes mellitus (DM) is divided into four different etiological categories: type 1 DM (T1DM), type 2 DM (T2DM), other specific types, and gestational DM. One severe complication of T2DM is type 2 diabetic nephropathy (T2DN). The possible association of serum transforming growth factor-β1 (TGF-β1) levels and the TGF-β1 T869C gene polymorphism with patient susceptibility to T2DN in Chinese population is unclear at present. This study was conducted to assess these relationships in Chinese population by a meta-analysis.MethodsAssociation reports were searched and pulled from the Cochrane Library, the China Biological Medicine Database (CBM), and PubMed on March 1, 2018, and eligible studies were selected and used for calculations. The results were expressed as weighted mean differences (MD) for continuous data. Odds ratios (OR) were used to express the results for dichotomous data. Additionally, 95% confidence intervals (CI) were calculated.ResultsForty-eight reports for the relationship between serum TGF-β1 levels and the risk of T2DN and 13 studies on the association of the TGF-β1 T869C gene polymorphism with susceptibility to T2DN in Chinese population were retrieved from this study. Serum TGF-β1 levels in the T2DM group were higher than those in the normal control group (MD = 17.30, 95% CI: 12.69–21.92, P < 0.00001). The serum TGF-β1 level in the T2DN group was significantly higher than that in the normal control group (MD = 70.03, 95% CI: 60.81–79.26, P < 0.00001;). The serum TGF-β1 level in the T2DN group was significantly higher than that in the T2DM group (MD = 56.18, 95% CI: 46.96–65.39, P < 0.00001). Serum TGF-β1 levels in T2DM patients with microalbuminuria were increased when compared with those in T2DM patients with normoalbuminuria. Furthermore, serum TGF-β1 levels in T2DM patients with macroalbuminuria were increased when compared with those in T2DM patients with microalbuminuria. The TGF-β1 T allele, TT allele and CC genotype were associated with T2DN susceptibility in Chinese population (T: OR = 0.74, 95% CI: 0.59–0.92, P = 0.007; TT: OR = 0.55, 95% CI: 0.31–0.96, P = 0.04; CC: OR = 1.38, 95% CI: 1.14–1.67, P = 0.001).ConclusionsHigh levels of TGF-β1 are associated with susceptibility to T2DM, T2DN and the progression of proteinuria in T2DN patients in Chinese population. Further, the TGF-β1 T allele, and TT genotype were protective factors against the onset of T2DN and CC genotype was a risk factor for the susceptibility of T2DN in Chinese populations.

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“…The relationships between BC and DM [ 32 , 33 ], insulin resistance [ 34 ], diabetic nephropathy [ 35 ], and diabetic peripheral arterial disease [ 36 ] have been established, thus confirming TCM patient classification theory and verifying a new TCM treatment strategy for DM [ 37 ]. However, the association between BC and DR has yet to be determined.…”

Section: Introductionmentioning

confidence: 88%

Yang Deficiency Body Constitution Acts as a Predictor of Diabetic Retinopathy in Patients with Type 2 Diabetes: Taichung Diabetic Body Constitution Study

Lee

Tsai

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Objective. Diabetic retinopathy (DR), the most common microvascular complication of diabetes mellitus (DM), can cause severe visual impairment and blindness. To prevent the development of DR, identifying the associated risk factors for patient classification is critical. We conducted a cross-sectional study to determine whether body constitution (BC) is an independent predictor of DR. Method. 673 type 2 DM (T2DM) patients were recruited from a medical center, all received DR examination and body constitution questionnaire to assess BC. Other risk factors for DR were also recorded, including life style, history of diabetes, and blood pressure, etc. Multiple logistic regression analysis was conducted to calculate the odds ratios (ORs) for DR. Results. The prevalence of DR was significantly lower in Yang deficiency patients compared with non-Yang deficiency patients (24.69% versus 38.18% P = 0.02). After adjusting for other risk factors, we observed that patients exhibiting Yang deficiency BC were less likely to present with DR (OR = 0.531; 95% confidence interval = 0.312–0.903, P = 0.018). Conclusion. In addition to traditional risk factors, Yang deficiency BC might be an independent predictor of DR among T2DM patients and the results can be used as evidence for traditional Chinese medicine patient classification.

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Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism

Abstract: Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism, a potential predictor of susceptibility to DN in T2DM patients.

Cited by 14 publications

References 6 publications

The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy

The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy

Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population

Yang Deficiency Body Constitution Acts as a Predictor of Diabetic Retinopathy in Patients with Type 2 Diabetes: Taichung Diabetic Body Constitution Study

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