Association of Childhood Lead Exposure With Adult Personality Traits and Lifelong Mental Health

Reuben, Aaron; Schaefer, Jonathan D.; Moffitt, Terrie E.; Broadbent, Jonathan M.; Harrington, HonaLee; Houts, Renate; Ramrakha, Sandhya; Poulton, Richie; Caspi, Avshalom

doi:10.1001/jamapsychiatry.2018.4192

Cited by 95 publications

(65 citation statements)

References 62 publications

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“…And in Ecuador, elevated mining‐metal exposure (particularly to manganese) has been associated with impaired neurocognitive function among children aged 5–11 years old ( N = 73 children tested via the Raven's Colored Progressive Matrices) (Betancourt et al, 2015). Impairments to neurological development have long‐term cognitive, mental, and physical health consequences (Bellinger, 2008; Brubaker et al, 2009; Reuben et al, 2017, 2019; Taber & Hurley, 2008) and can significantly reduce economic productivity. Notably, loss of neurocognitive function due to methylmercury exposure has been associated with a net population decline of 600,000 IQ points across Europe and economic losses of $9B–$10B per year (Bellanger et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Elevated Hair Mercury Levels Are Associated With Neurodevelopmental Deficits in Children Living Near Artisanal and Small‐Scale Gold Mining in Peru

et al. 2020

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Children living near artisanal and small-scale gold mining (ASGM) are at risk of exposure to mercury, a neurotoxicant. It is not certain whether such exposures are harming development, as they occur in underresourced contexts entwined with other stressors, such as malnutrition and enteric infection.This study sought to investigate the association between hair-mercury levels and visual-motor, cognitive, and physical development among children living near ASGM in the Peruvian Amazon. Total hair-mercury levels were measured in 164 children ages 5-

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Section: Discussionmentioning

confidence: 99%

Elevated Hair Mercury Levels Are Associated With Neurodevelopmental Deficits in Children Living Near Artisanal and Small‐Scale Gold Mining in Peru

et al. 2020

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“…In addition, children growing up in low SES neighborhoods are more to have higher lead exposure than children in high SES neighborhoods (Berg, Kuhn, & Van Dyke, ). Such exposure in childhood has been associated with worse psychological outcomes in adolescence (Winter & Sampson, ), an association that continues into adulthood and that extends to personality (Reuben et al, ). Chronic exposure to more dangerous or unpredictable environments may also result in long‐lasting behavioral adaptations that maximize immediate safety, such as avoiding strangers or quickly reacting to perceived threats, which may become general tendencies associated with lower sociability and higher reactivity (e.g., Chen, Shi, & Sun, ).…”

Section: Discussionmentioning

confidence: 99%

Family and neighborhood socioeconomic status and temperament development from childhood to adolescence

Strickhouser

Sutin

2019

Journal of Personality

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Objective: Children differ in their temperament and these differences predict consequential outcomes, including mental health, peer relations, substance use, academic performance, and adult personality. Additionally, children's temperament develops over time in response to environmental factors, such as the socioeconomic status (SES) of their family and the neighborhood in which they are raised. However, there has been lack on research on the relation between neighborhood SES and the development of temperament or personality. Method: Using data from two cohorts of the Longitudinal Study of Australian Children (LSAC; N = 9,217) that followed children from 4 to 15 years old, the present analyses examined whether parent income, parent education, and neighborhood disadvantage were associated with three child temperament traits that are precursors to Five-Factor Model (FFM) adult personality traits. Results: Longitudinal hierarchical linear models (HLM) generally found that children with lower neighborhood SES or family SES tended to have lower sociability, higher reactivity, and lower persistence and these associations did not decrease over time.Conclusions: This research demonstrates that both the neighborhood and the family SES in childhood are important for the development of temperament across childhood and adolescence. K E Y W O R D Schildren, longitudinal, personality, socioeconomic status, temperament

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“…Arinola and colleagues also found increased plasma lead concentrations in newly diagnosed schizophrenic subjects [115]. Another study using a multidecade longitudinal design of lead-exposed children showed that higher levels of blood lead were associated with greater psychopathology and difficult personality traits as adults [116]. Childhood lead intoxication has also been associated with a high level of incarceration, delinquent behavior, and substance abuse, which are comorbid factors in schizophrenia [13,[117][118][119].…”

Section: Modification Of Synaptic Transmission By Environmental Exposmentioning

confidence: 99%

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

Hollander

Cory‐Slechta

Jacka

et al. 2020

Neuropsychopharmacol.

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The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizophrenia) have, in contrast, lagged behind heritable frameworks of explanation. Thus, the association of neuropsychiatric illness to environmental chemical exposure, and their potential interactions with genetic susceptibility, are largely unexplored. In this review, we describe emerging approaches for considering the impact of chemical risk factors acting alone and in concert with genetic risk, and point to the potential role of epigenetics in mediating exposure effects on transcription of genes implicated in mental disorders. We highlight recent examples of research in nongenetic risk factors in psychiatric disorders that point to potential shared biological mechanisms-synaptic dysfunction, immune alterations, and gut-brain interactions. We outline new tools and resources that can be harnessed for the study of environmental factors in psychiatric disorders. These tools, combined with emerging experimental evidence, suggest that there is a need to broadly incorporate environmental exposures in psychiatric research, with the ultimate goal of identifying modifiable risk factors and informing new treatment strategies for neuropsychiatric disease.

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Association of Childhood Lead Exposure With Adult Personality Traits and Lifelong Mental Health

Abstract: This cohort study assesses whether exposure to lead during childhood is associated with lifelong mental health disorder symptoms and difficult personality traits in adulthood.

Cited by 95 publications

References 62 publications

Elevated Hair Mercury Levels Are Associated With Neurodevelopmental Deficits in Children Living Near Artisanal and Small‐Scale Gold Mining in Peru

Elevated Hair Mercury Levels Are Associated With Neurodevelopmental Deficits in Children Living Near Artisanal and Small‐Scale Gold Mining in Peru

Family and neighborhood socioeconomic status and temperament development from childhood to adolescence

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

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